Basic Information
ID: ALA3215006
Type: Binding
Description: PubChem BioAssay. Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2). (Class of assay: confirmatory)
Activity Charts
Bioactivity
Activity Types for Assay ALA3215006
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 355.43 | 3.47 | 3.47 |
| 208.22 | 2.73 | 2.73 |
| 223.23 | 2.31 | 2.31 |
| 223.62 | 1.64 | 1.64 |
| 272.31 | 3.66 | 3.66 |
| 174.16 | 0.15 | 0.15 |
| 280.33 | 2.29 | 2.29 |
| 328.35 | 1.55 | 1.55 |
| 210.19 | 1.52 | 1.52 |
| 339.39 | 3.18 | 3.18 |
| 366.39 | 3.47 | 3.47 |
| 346.43 | 4.18 | 4.18 |
| 332.40 | 3.88 | 3.88 |
| 410.39 | 3.49 | 3.49 |
| 290.75 | 1.76 | 1.76 |
| 327.38 | 2.77 | 2.77 |
| 448.94 | 5.09 | 5.09 |
| 357.81 | 0.68 | 0.68 |
| 369.76 | 3.27 | 3.27 |
| 284.28 | 1.56 | 1.56 |
| 452.54 | 4.36 | 4.36 |
| 318.76 | 1.71 | 1.71 |
| 433.51 | 3.92 | 3.92 |
| 334.41 | 1.17 | 1.17 |
| 466.56 | 4.67 | 4.67 |
| 282.25 | 2.75 | 2.75 |
| 235.25 | -0.67 | -0.67 |
| 334.37 | 3.48 | 3.48 |
| 190.15 | 1.39 | 1.39 |
| 434.45 | 3.43 | 3.43 |
| 468.35 | 4.29 | 4.29 |
| 500.51 | 3.87 | 3.87 |
| 376.33 | ||
| 305.38 | 3.41 | 3.41 |
| 418.72 | 1.31 | 1.31 |
| 408.41 | 3.39 | 3.39 |
| 371.23 | 4.26 | 4.26 |
| 485.34 | 5.17 | 5.17 |
| 369.36 | 1.33 | 1.33 |
| 212.64 | 1.52 | 1.52 |
| 862.75 | -1.10 | -1.10 |
| 263.30 | 3.21 | 3.21 |
| 309.32 | 1.80 | 1.80 |
| 349.26 | 2.20 | 2.20 |
| 322.36 | 2.28 | 2.28 |
| 291.65 | 2.92 | 2.92 |
| 408.41 | 3.39 | 3.39 |
| 283.28 | 2.55 | 2.55 |
| 424.41 | 2.38 | 2.38 |
| 260.32 | 2.68 | 2.68 |
| 394.39 | 3.30 | 3.30 |
| 402.88 | 5.41 | 5.41 |
| 290.42 | 3.06 | 3.06 |
| 338.36 | 1.98 | 1.98 |
| 207.19 | 0.97 | 0.97 |
| 526.59 | 5.29 | 5.29 |
| 316.41 | 3.73 | 3.73 |
| 241.29 | 2.28 | 2.28 |
| 347.24 | 4.32 | 4.32 |
| 542.39 | 5.34 | 5.34 |
| 300.31 | 2.78 | 2.78 |
| 267.12 | ||
| 534.66 | 5.33 | 5.33 |
| 363.37 | 3.26 | 3.26 |
| 458.28 | 5.05 | 5.05 |
| 374.44 | 3.30 | 3.30 |
| 410.45 | 1.48 | 1.48 |
| 278.41 | 2.87 | 2.87 |
| 394.39 | 3.30 | 3.30 |
| 334.83 | 6.05 | 6.05 |
| 260.30 | 3.16 | 3.16 |
| 394.39 | 3.30 | 3.30 |
| 264.38 | 2.48 | 2.48 |
| 177.20 | 0.74 | 0.74 |
| 289.29 | 1.04 | 1.04 |
| 316.31 | 0.62 | 0.62 |
| 352.42 | 3.98 | 3.98 |
| 295.29 | 1.11 | 1.11 |
| 447.93 | 5.00 | 5.00 |
| 360.37 | 2.01 | 2.01 |
| 408.09 | 5.08 | 5.08 |
| 300.31 | 3.73 | 3.73 |
| 259.53 | 2.58 | 2.58 |
| 315.17 | 4.45 | 4.45 |
| 243.26 | 1.13 | 1.13 |
| 315.40 | 3.01 | 3.01 |
| 350.16 | 2.49 | 2.49 |
| 385.38 | 1.10 | 1.10 |
| 282.25 | -0.72 | -0.72 |
| 317.37 | 4.68 | 4.68 |
| 270.25 | -0.56 | -0.56 |
| 406.44 | 4.41 | 4.41 |
| 419.48 | 3.53 | 3.53 |
| 348.32 | 2.40 | 2.40 |
| 316.31 | 3.87 | 3.87 |
| 220.23 | 0.64 | 0.64 |
| 398.37 | 3.41 | 3.41 |
| 227.27 | 1.30 | 1.30 |
| 331.31 | 3.06 | 3.06 |
| 396.38 | 2.48 | 2.48 |
| 324.29 | 2.59 | 2.59 |
| 409.41 | 4.30 | 4.30 |
| 267.12 | ||
| 430.44 | 2.64 | 2.64 |
| 416.43 | 4.70 | 4.70 |
| 278.27 | 0.68 | 0.68 |
| 436.35 | 3.47 | 3.47 |
| 323.74 | 2.25 | 2.25 |
| 281.27 | 1.18 | 1.18 |
| 292.43 | 3.26 | 3.26 |
| 272.26 | 0.80 | 0.80 |
| 330.34 | 2.06 | 2.06 |
| 313.81 | 4.70 | 4.70 |
| 218.26 | 1.80 | 1.80 |
| 408.41 | 3.39 | 3.39 |
| 316.40 | 4.03 | 4.03 |
| 254.26 | 3.82 | 3.82 |
| 159.19 | 1.52 | 1.52 |
| 331.80 | 3.70 | 3.70 |
| 251.24 | 3.05 | 3.05 |
| 282.34 | 2.16 | 2.16 |
| 387.83 | 4.55 | 4.55 |
| 278.38 | 3.34 | 3.34 |
| 376.41 | 2.92 | 2.92 |
| 369.43 | 4.51 | 4.51 |
| 297.27 | 1.00 | 1.00 |
| 260.25 | 0.65 | 0.65 |
| 281.25 | 0.42 | 0.42 |
| 459.51 | 2.41 | 2.41 |
| 327.47 | 4.36 | 4.36 |
| 403.87 | 5.16 | 5.16 |
| 256.10 | 1.50 | 1.50 |
| 290.27 | 0.63 | 0.63 |
| 348.32 | 2.40 | 2.40 |
| 260.25 | 0.59 | 0.59 |
| 362.35 | 2.70 | 2.70 |
| 367.49 | 5.03 | 5.03 |
| 397.48 | 4.03 | 4.03 |
| 340.40 | 2.75 | 2.75 |
| 432.27 | 4.26 | 4.26 |
| 273.29 | 1.26 | 1.26 |
| 453.09 | 4.17 | 4.17 |
| 329.74 | 1.77 | 1.77 |
| 417.51 | 4.09 | 4.09 |
| 237.26 | 3.08 | 3.08 |
| 518.62 | 4.71 | 4.71 |
| 264.32 | 3.97 | 3.97 |
| 308.34 | 2.74 | 2.74 |
| 574.58 | 4.16 | 4.16 |
| 354.41 | 5.55 | 5.55 |
| 277.71 | 2.43 | 2.43 |
| 253.10 | 2.59 | 2.59 |
| 254.25 | 2.20 | 2.20 |
| 296.33 | 3.70 | 3.70 |
| 191.14 | 0.45 | 0.45 |
| 487.97 | 2.92 | 2.92 |
| 293.32 | 3.30 | 3.30 |
| 484.50 | 4.13 | 4.13 |
| 277.28 | 2.38 | 2.38 |
| 345.20 | 4.46 | 4.46 |
| 270.72 | 4.34 | 4.34 |
| 217.66 | 4.15 | 4.15 |
| 296.20 | 1.98 | 1.98 |
| 529.50 | 4.04 | 4.04 |
| 250.26 | 2.30 | 2.30 |
| 458.04 | 5.09 | 5.09 |
| 523.53 | 2.71 | 2.71 |
| 255.23 | 1.12 | 1.12 |
| 324.34 | 2.57 | 2.57 |
| 400.91 | 3.29 | 3.29 |
| 373.41 | 4.07 | 4.07 |
| 286.70 | 0.12 | 0.12 |
| 253.06 | 1.03 | 1.03 |
| 452.10 | 4.09 | 4.09 |
| 287.41 | 3.35 | 3.35 |
| 438.49 | 3.82 | 3.82 |
| 250.24 | 1.92 | 1.92 |
| 323.31 | 2.76 | 2.76 |
| 242.24 | 1.41 | 1.41 |
| 304.78 | 5.35 | 5.35 |
| 460.51 | 4.37 | 4.37 |
| 446.48 | 4.06 | 4.06 |
| 346.39 | 2.28 | 2.28 |
| 305.36 | 4.30 | 4.30 |
| 300.27 | 1.17 | 1.17 |
| 348.40 | 4.07 | 4.07 |
| 265.27 | 3.15 | 3.15 |
| 232.25 | 0.45 | 0.45 |
| 432.46 | 3.76 | 3.76 |
| 446.48 | 4.06 | 4.06 |
| 310.38 | 3.65 | 3.65 |
| 410.48 | 3.82 | 3.82 |
| 879.86 | 6.39 | 6.39 |
| 230.27 | 2.17 | 2.17 |
| 327.77 | 4.00 | 4.00 |
| 323.35 | 3.35 | 3.35 |
| 353.38 | 2.89 | 2.89 |
| 216.26 | -0.16 | -0.16 |
| 337.38 | 3.19 | 3.19 |
| 364.45 | 1.70 | 1.70 |
| 204.23 | 1.48 | 1.48 |
| 496.57 | 4.46 | 4.46 |
| 216.28 | 2.46 | 2.46 |
| 480.52 | 4.14 | 4.14 |
| 496.57 | 4.46 | 4.46 |
| 330.26 | 1.40 | 1.40 |
| 478.55 | 5.97 | 5.97 |
| 367.32 | 2.49 | 2.49 |
| 317.34 | 1.82 | 1.82 |
| 289.29 | 1.04 | 1.04 |
| 318.12 | 1.00 | 1.00 |
| 460.51 | 4.32 | 4.32 |
| 263.30 | 4.00 | 4.00 |
| 313.28 | 1.61 | 1.61 |
| 293.28 | 2.60 | 2.60 |
| 548.60 | 3.18 | 3.18 |
| 287.77 | 5.01 | 5.01 |
| 408.50 | 4.43 | 4.43 |
| 310.38 | 3.65 | 3.65 |
| 326.38 | 3.35 | 3.35 |
| 332.28 | 2.78 | 2.78 |