Basic Information
ID: ALA3215228
Type: Binding
Description: PubChem BioAssay. Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput dose response assay to identify inhibitors of ADAM10. (Class of assay: confirmatory)
Activity Charts
Bioactivity
Activity Types for Assay ALA3215228
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 331.41 | -0.21 | -0.21 |
| 385.51 | 1.20 | 1.20 |
| 362.48 | 5.79 | 5.79 |
| 456.52 | 2.83 | 2.83 |
| 437.56 | 5.29 | 5.29 |
| 429.48 | 3.71 | 3.71 |
| 484.38 | 5.25 | 5.25 |
| 458.97 | 3.86 | 3.86 |
| 363.42 | 4.06 | 4.06 |
| 368.48 | 5.60 | 5.60 |
| 490.40 | 6.14 | 6.14 |
| 502.50 | 4.50 | 4.50 |
| 383.56 | 5.57 | 5.57 |
| 359.42 | 4.62 | 4.62 |
| 437.55 | 4.68 | 4.68 |
| 392.48 | 4.09 | 4.09 |
| 366.87 | 3.89 | 3.89 |
| 360.45 | 5.07 | 5.07 |
| 420.32 | 5.61 | 5.61 |
| 509.44 | 2.87 | 2.87 |
| 486.59 | 5.06 | 5.06 |
| 370.43 | 3.68 | 3.68 |
| 252.27 | 3.42 | 3.42 |
| 445.32 | 3.89 | 3.89 |
| 491.68 | 3.32 | 3.32 |
| 517.03 | 5.99 | 5.99 |
| 483.61 | 5.83 | 5.83 |
| 369.18 | 3.97 | 3.97 |
| 362.84 | 3.91 | 3.91 |
| 310.40 | 2.09 | 2.09 |
| 398.44 | 4.00 | 4.00 |
| 493.59 | 2.77 | 2.77 |
| 302.74 | 3.49 | 3.49 |
| 483.37 | 4.20 | 4.20 |
| 511.65 | 4.68 | 4.68 |
| 862.75 | -1.10 | -1.10 |
| 388.27 | 4.77 | 4.77 |
| 400.72 | 5.93 | 5.93 |
| 364.43 | 3.74 | 3.74 |
| 420.47 | 3.93 | 3.93 |
| 407.39 | 4.25 | 4.25 |
| 314.77 | 4.50 | 4.50 |
| 363.41 | 4.74 | 4.74 |
| 405.48 | 4.40 | 4.40 |
| 433.71 | 2.98 | 2.98 |
| 558.66 | 5.67 | 5.67 |
| 291.44 | 3.61 | 3.61 |
| 439.92 | 4.77 | 4.77 |
| 496.56 | 5.36 | 5.36 |
| 269.73 | 4.87 | 4.87 |
| 455.49 | 2.30 | 2.30 |
| 457.58 | 4.41 | 4.41 |
| 465.47 | 3.84 | 3.84 |
| 219.24 | 1.68 | 1.68 |
| 495.00 | 5.57 | 5.57 |
| 297.38 | 3.42 | 3.42 |
| 323.39 | 3.64 | 3.64 |
| 366.37 | 3.88 | 3.88 |
| 358.28 | 4.71 | 4.71 |
| 505.41 | 5.01 | 5.01 |
| 498.95 | 4.04 | 4.04 |
| 419.48 | 1.93 | 1.93 |
| 405.45 | 4.10 | 4.10 |
| 310.40 | 3.30 | 3.30 |
| 550.55 | 4.14 | 4.14 |
| 422.71 | 5.13 | 5.13 |
| 435.55 | 3.31 | 3.31 |
| 370.84 | 4.83 | 4.83 |
| 387.46 | 2.34 | 2.34 |
| 405.45 | 3.91 | 3.91 |
| 534.62 | 5.29 | 5.29 |
| 399.43 | 2.23 | 2.23 |
| 428.44 | 5.58 | 5.58 |
| 421.54 | 5.16 | 5.16 |
| 339.51 | 5.16 | 5.16 |
| 392.28 | 4.00 | 4.00 |
| 424.53 | 4.32 | 4.32 |
| 272.30 | 3.52 | 3.52 |
| 490.63 | 4.09 | 4.09 |
| 311.34 | 3.44 | 3.44 |
| 480.49 | 3.27 | 3.27 |
| 405.53 | 4.17 | 4.17 |
| 406.46 | 4.42 | 4.42 |
| 217.22 | 2.22 | 2.22 |
| 313.83 | 5.25 | 5.25 |
| 322.60 | 4.46 | 4.46 |
| 510.57 | 5.95 | 5.95 |
| 203.14 | 1.41 | 1.41 |
| 319.36 | 5.03 | 5.03 |
| 456.57 | 5.05 | 5.05 |
| 349.41 | 4.68 | 4.68 |
| 375.22 | 3.81 | 3.81 |
| 440.41 | 5.70 | 5.70 |
| 500.54 | 5.99 | 5.99 |
| 395.80 | 2.71 | 2.71 |
| 353.85 | 4.56 | 4.56 |
| 434.49 | 3.04 | 3.04 |
| 277.78 | 3.22 | 3.22 |
| 351.47 | 4.66 | 4.66 |
| 263.30 | 1.29 | 1.29 |
| 342.40 | 4.73 | 4.73 |
| 314.38 | 4.77 | 4.77 |
| 390.44 | 5.34 | 5.34 |
| 482.54 | 3.79 | 3.79 |
| 571.08 | 3.79 | 3.79 |
| 455.50 | 4.24 | 4.24 |
| 524.60 | 4.17 | 4.17 |
| 398.48 | 3.37 | 3.37 |
| 348.81 | 3.70 | 3.70 |
| 420.89 | 4.32 | 4.32 |
| 362.43 | 4.77 | 4.77 |
| 330.39 | 3.58 | 3.58 |
| 535.35 | 4.71 | 4.71 |
| 264.39 | 1.27 | 1.27 |
| 387.44 | 4.71 | 4.71 |
| 487.58 | 4.53 | 4.53 |
| 512.42 | 4.16 | 4.16 |
| 366.37 | 3.28 | 3.28 |
| 478.51 | 3.61 | 3.61 |
| 431.59 | 6.37 | 6.37 |
| 326.31 | 1.36 | 1.36 |
| 507.02 | 6.55 | 6.55 |
| 557.65 | 2.48 | 2.48 |
| 432.54 | 4.41 | 4.41 |
| 400.50 | 4.26 | 4.26 |
| 414.53 | 3.89 | 3.89 |
| 405.46 | 5.44 | 5.44 |
| 343.34 | 1.74 | 1.74 |
| 532.49 | 6.21 | 6.21 |
| 252.36 | 2.13 | 2.13 |
| 499.64 | 5.42 | 5.42 |
| 326.38 | 3.28 | 3.28 |
| 275.35 | 3.05 | 3.05 |
| 335.47 | 3.39 | 3.39 |
| 385.45 | 2.51 | 2.51 |
| 419.87 | 4.36 | 4.36 |
| 440.53 | 4.87 | 4.87 |
| 348.36 | 4.95 | 4.95 |
| 480.59 | 3.18 | 3.18 |
| 448.55 | 2.56 | 2.56 |
| 471.02 | 4.96 | 4.96 |
| 382.42 | 4.54 | 4.54 |
| 318.21 | 5.23 | 5.23 |
| 345.46 | 3.84 | 3.84 |
| 392.91 | 5.67 | 5.67 |
| 424.34 | 4.19 | 4.19 |
| 341.87 | 4.79 | 4.79 |
| 428.54 | 4.37 | 4.37 |
| 351.34 | 4.02 | 4.02 |
| 452.58 | 4.14 | 4.14 |
| 437.42 | 6.10 | 6.10 |
| 371.51 | 3.93 | 3.93 |
| 342.39 | 5.45 | 5.45 |
| 487.01 | 4.76 | 4.76 |
| 580.11 | 4.22 | 4.22 |
| 497.98 | 2.30 | 2.30 |
| 479.62 | 5.02 | 5.02 |
| 305.79 | 2.22 | 2.22 |
| 431.32 | 3.78 | 3.78 |
| 578.73 | 4.79 | 4.79 |
| 536.10 | 2.63 | 2.63 |
| 630.75 | 3.59 | 3.59 |
| 568.57 | 6.50 | 6.50 |
| 354.43 | 4.24 | 4.24 |
| 389.45 | 3.80 | 3.80 |
| 399.45 | 5.16 | 5.16 |
| 487.00 | 5.13 | 5.13 |
| 440.50 | 3.82 | 3.82 |
| 450.44 | 4.33 | 4.33 |
| 667.82 | 6.00 | 6.00 |
| 542.63 | 5.23 | 5.23 |
| 479.44 | 4.74 | 4.74 |
| 491.42 | 6.33 | 6.33 |
| 480.62 | 4.15 | 4.15 |
| 371.33 | 5.19 | 5.19 |
| 497.62 | 5.92 | 5.92 |
| 496.58 | 3.75 | 3.75 |
| 563.62 | 5.55 | 5.55 |
| 471.61 | 3.67 | 3.67 |
| 373.46 | 4.10 | 4.10 |
| 586.70 | 4.85 | 4.85 |
| 548.44 | 5.27 | 5.27 |
| 431.54 | 2.60 | 2.60 |
| 210.62 | 1.22 | 1.22 |
| 343.88 | 5.67 | 5.67 |
| 441.40 | 5.99 | 5.99 |
| 413.26 | 4.81 | 4.81 |
| 280.33 | 2.27 | 2.27 |
| 346.34 | 2.46 | 2.46 |
| 387.46 | 2.85 | 2.85 |
| 300.75 | 2.62 | 2.62 |
| 388.49 | 5.20 | 5.20 |
| 664.85 | 6.98 | 6.98 |
| 602.74 | 3.94 | 3.94 |
| 429.40 | 4.50 | 4.50 |
| 494.53 | 3.19 | 3.19 |
| 375.48 | 3.59 | 3.59 |
| 480.59 | 4.46 | 4.46 |
| 424.50 | 4.93 | 4.93 |
| 508.64 | 3.99 | 3.99 |
| 436.49 | 3.71 | 3.71 |
| 484.47 | 5.46 | 5.46 |
| 593.71 | 3.80 | 3.80 |
| 516.70 | 4.59 | 4.59 |
| 449.35 | 4.47 | 4.47 |
| 521.64 | 4.08 | 4.08 |
| 490.39 | 5.16 | 5.16 |
| 606.86 | 6.27 | 6.27 |
| 337.40 | 3.74 | 3.74 |
| 599.74 | 6.69 | 6.69 |
| 555.53 | 5.72 | 5.72 |
| 528.41 | 5.11 | 5.11 |
| 447.39 | 4.88 | 4.88 |
| 650.60 | 4.91 | 4.91 |
| 510.59 | 5.74 | 5.74 |
| 422.00 | 5.52 | 5.52 |
| 394.50 | 5.77 | 5.77 |
| 622.81 | 6.59 | 6.59 |
| 527.05 | 6.90 | 6.90 |
| 549.49 | 3.91 | 3.91 |
| 462.98 | 5.23 | 5.23 |
| 442.52 | 4.10 | 4.10 |
| 417.53 | 5.61 | 5.61 |
| 533.70 | 7.02 | 7.02 |
| 486.57 | 3.53 | 3.53 |
| 424.50 | 5.04 | 5.04 |
| 698.75 | 3.62 | 3.62 |
| 336.39 | 4.37 | 4.37 |
| 499.55 | 4.51 | 4.51 |
| 373.48 | 3.10 | 3.10 |
| 455.51 | 5.17 | 5.17 |
| 482.38 | 4.99 | 4.99 |
| 451.37 | 3.61 | 3.61 |
| 498.38 | 4.39 | 4.39 |
| 415.90 | 4.15 | 4.15 |
| 372.48 | 2.85 | 2.85 |
| 403.87 | 3.42 | 3.42 |
| 354.45 | 3.65 | 3.65 |
| 466.38 | 5.29 | 5.29 |
| 312.44 | 4.16 | 4.16 |
| 283.33 | 4.05 | 4.05 |
| 313.32 | 0.85 | 0.85 |
| 453.50 | 4.59 | 4.59 |
| 357.79 | 4.56 | 4.56 |
| 368.39 | 4.50 | 4.50 |
| 310.40 | 1.20 | 1.20 |
| 346.37 | 2.35 | 2.35 |
| 436.54 | 4.14 | 4.14 |