Basic Information
ID: ALA3280057
Type: Binding
Description: Antagonist activity at beta-1 adrenergic receptor in spontaneously beating guinea pig right atrium assessed as inhibition of isoprenaline-induced positive chronotropic effect preincubated for 30 mins followed by isoprenaline challenge in presence of ascorbic acid
Organism: Cavia porcellus
Tissue: Cardiac atrium
Activity Charts
Bioactivity
Activity Types for Assay ALA3280057
pA2(app)
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 272.78 | 1.40 | 1.40 |
| 286.80 | 1.79 | 1.79 |
| 286.80 | 1.79 | 1.79 |
| 300.83 | 2.18 | 2.18 |
| 411.37 | 4.05 | 4.05 |
| 298.81 | 1.71 | 1.71 |
| 312.84 | 2.10 | 2.10 |
| 312.84 | 2.10 | 2.10 |
| 406.48 | 2.49 | 2.49 |
| 434.96 | 2.95 | 2.95 |
| 416.47 | 2.94 | 2.94 |
| 348.87 | 2.81 | 2.81 |
| 362.90 | 3.20 | 3.20 |
| 495.53 | 2.66 | 2.66 |
| 366.41 | 1.27 | 1.27 |
| 376.88 | 3.17 | 3.17 |
| 346.86 | 2.79 | 2.79 |
| 360.89 | 3.19 | 3.19 |
| 436.98 | 4.41 | 4.41 |
| 405.88 | 3.09 | 3.09 |
| 518.68 | 4.71 | 4.71 |
| 519.39 | 3.95 | 3.95 |
| 519.39 | 3.95 | 3.95 |
| 395.33 | 3.84 | 3.84 |
| 531.56 | 3.14 | 3.14 |
| 393.92 | 2.77 | 2.77 |
| 335.28 | 2.83 | 2.83 |
| 394.47 | 2.48 | 2.48 |
| 330.86 | 2.18 | 2.18 |
| 345.83 | 2.08 | 2.08 |
| 459.34 | 2.94 | 2.94 |
| 369.42 | 1.76 | 1.76 |
| 408.50 | 2.74 | 2.74 |
| 422.52 | 3.30 | 3.30 |
| 379.41 | 2.05 | 2.05 |
| 362.92 | 1.91 | 1.91 |
| 378.92 | 1.58 | 1.58 |
| 318.82 | 2.32 | 2.32 |
| 346.92 | 2.90 | 2.90 |
| 376.93 | 3.84 | 3.84 |
| 437.49 | 2.13 | 2.13 |
| 343.38 | 1.88 | 1.88 |
| 438.52 | 2.96 | 2.96 |
| 443.50 | 2.22 | 2.22 |
| 407.96 | 1.43 | 1.43 |
| 394.47 | 2.48 | 2.48 |
| 396.44 | 1.88 | 1.88 |
| 410.47 | 2.18 | 2.18 |
| 414.89 | 2.83 | 2.83 |
| 394.47 | 2.48 | 2.48 |
| 436.51 | 2.74 | 2.74 |
| 369.72 | 3.48 | 3.48 |
| 360.88 | 2.19 | 2.19 |
| 449.33 | 3.48 | 3.48 |
| 440.49 | 2.19 | 2.19 |