Assay Report Card

Basic Information

ID: ALA3280058

Type: Binding

Description: Antagonist activity at beta-2 adrenergic receptor in carbachol-treated guinea pig trachea assessed as inhibition of isoprenaline-induced contraction preincubated for 60 mins followed by isoprenaline challenge in presence of ascorbic acid and phentolamine

Organism: Cavia porcellus

Tissue: Trachea

Activity Charts

Bioactivity

Activity Types for Assay ALA3280058

pA2(app)

Total(62)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
272.78	1.40	1.40
286.80	1.79	1.79
286.80	1.79	1.79
300.83	2.18	2.18
411.37	4.05	4.05
298.81	1.71	1.71
312.84	2.10	2.10
312.84	2.10	2.10
406.48	2.49	2.49
434.96	2.95	2.95
416.47	2.94	2.94
322.84	2.55	2.55
348.87	2.81	2.81
362.90	3.20	3.20
495.53	2.66	2.66
366.41	1.27	1.27
374.91	2.91	2.91
388.94	3.30	3.30
386.92	3.57	3.57
372.90	3.18	3.18
362.86	2.78	2.78
376.88	3.17	3.17
346.86	2.79	2.79
360.89	3.19	3.19
468.98	3.65	3.65
436.98	4.41	4.41
405.88	3.09	3.09
518.68	4.71	4.71
519.39	3.95	3.95
519.39	3.95	3.95
395.33	3.84	3.84
531.56	3.14	3.14
393.92	2.77	2.77
335.28	2.83	2.83
394.47	2.48	2.48
330.86	2.18	2.18
345.83	2.08	2.08
459.34	2.94	2.94
369.42	1.76	1.76
408.50	2.74	2.74
422.52	3.30	3.30
379.41	2.05	2.05
362.92	1.91	1.91
378.92	1.58	1.58
318.82	2.32	2.32
346.92	2.90	2.90
376.93	3.84	3.84
437.49	2.13	2.13
343.38	1.88	1.88
438.52	2.96	2.96
443.50	2.22	2.22
407.96	1.43	1.43
394.47	2.48	2.48
396.44	1.88	1.88
410.47	2.18	2.18
414.89	2.83	2.83
394.47	2.48	2.48
436.51	2.74	2.74
369.72	3.48	3.48
360.88	2.19	2.19
449.33	3.48	3.48
440.49	2.19	2.19