Basic Information
ID: ALA3301362
Type: Physicochemical
Description: ASTRAZENECA: Most basic pKa value (pKa B1) determined by absorption and potentiometric titration using standard methodology from Sirius Analytical. Experimental range Bases: >= 2.
Activity Charts
Bioactivity
Activity Types for Assay ALA3301362
pKa_B1
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 361.37 | 1.54 | 1.54 |
| 399.40 | 2.72 | 2.72 |
| 369.34 | 1.70 | 1.70 |
| 331.35 | 1.58 | 1.58 |
| 280.42 | 3.88 | 3.88 |
| 290.32 | 1.26 | 1.26 |
| 454.61 | 5.09 | 5.09 |
| 414.53 | 3.37 | 3.37 |
| 307.43 | 2.39 | 2.39 |
| 375.40 | 1.98 | 1.98 |
| 401.44 | 2.37 | 2.37 |
| 389.39 | 0.97 | 0.97 |
| 309.33 | 4.44 | 4.44 |
| 326.83 | 3.72 | 3.72 |
| 186.26 | 1.73 | 1.73 |
| 293.37 | 3.13 | 3.13 |
| 192.29 | 1.79 | 1.79 |
| 385.51 | 2.09 | 2.09 |
| 375.87 | 4.43 | 4.43 |
| 441.58 | 1.98 | 1.98 |
| 273.19 | -0.44 | -0.44 |
| 271.35 | 2.28 | 2.28 |
| 257.32 | 2.27 | 2.27 |
| 351.41 | 1.56 | 1.56 |
| 410.49 | 3.59 | 3.59 |
| 248.33 | 1.91 | 1.91 |
| 247.38 | 3.37 | 3.37 |
| 292.34 | 2.86 | 2.86 |
| 274.80 | 3.82 | 3.82 |
| 333.36 | 1.61 | 1.61 |
| 309.43 | 4.01 | 4.01 |
| 265.35 | 1.99 | 1.99 |
| 306.28 | 0.74 | 0.74 |
| 365.79 | 2.36 | 2.36 |
| 179.26 | 2.03 | 2.03 |
| 351.35 | 1.80 | 1.80 |
| 376.45 | 1.60 | 1.60 |
| 670.86 | 3.09 | 3.09 |
| 276.38 | 2.55 | 2.55 |
| 471.69 | 6.45 | 6.45 |
| 337.35 | 1.12 | 1.12 |
| 389.55 | 3.63 | 3.63 |
| 277.41 | 3.04 | 3.04 |
| 235.33 | 1.34 | 1.34 |
| 336.43 | 2.37 | 2.37 |
| 325.45 | 2.37 | 2.37 |
| 325.77 | 4.32 | 4.32 |
| 287.36 | 1.85 | 1.85 |
| 171.16 | 0.09 | 0.09 |
| 229.26 | -0.59 | -0.59 |
| 179.22 | 0.91 | 0.91 |
| 256.10 | 2.01 | 2.01 |
| 210.28 | 2.38 | 2.38 |
| 165.19 | 0.70 | 0.70 |
| 160.22 | 1.23 | 1.23 |
| 167.21 | 0.86 | 0.86 |
| 586.20 | 8.95 | 8.95 |
| 179.31 | 2.69 | 2.69 |
| 187.20 | 1.43 | 1.43 |
| 311.41 | 1.77 | 1.77 |
| 320.32 | 0.66 | 0.66 |
| 477.05 | 5.09 | 5.09 |
| 171.17 | 0.74 | 0.74 |
| 392.41 | 2.08 | 2.08 |
| 458.58 | 5.35 | 5.35 |
| 277.33 | 3.29 | 3.29 |
| 241.32 | 3.25 | 3.25 |
| 271.35 | 3.26 | 3.26 |
| 239.75 | 3.30 | 3.30 |
| 204.23 | 1.15 | 1.15 |
| 501.67 | 5.51 | 5.51 |
| 221.65 | 2.08 | 2.08 |
| 144.18 | 1.82 | 1.82 |
| 289.42 | 3.38 | 3.38 |
| 123.16 | 0.55 | 0.55 |
| 144.18 | 1.82 | 1.82 |
| 122.17 | 1.28 | 1.28 |
| 96.13 | 0.97 | 0.97 |
| 82.11 | 0.72 | 0.72 |
| 157.21 | 0.84 | 0.84 |
| 388.90 | 3.15 | 3.15 |
| 133.15 | 1.15 | 1.15 |
| 244.38 | 3.15 | 3.15 |
| 201.23 | 1.74 | 1.74 |
| 183.21 | 2.21 | 2.21 |
| 364.42 | 3.04 | 3.04 |
| 253.72 | 1.72 | 1.72 |
| 365.41 | 0.02 | 0.02 |
| 277.37 | 1.72 | 1.72 |
| 313.42 | 1.13 | 1.13 |
| 527.67 | 5.99 | 5.99 |
| 282.44 | 2.02 | 2.02 |
| 345.83 | 3.46 | 3.46 |
| 311.38 | 2.81 | 2.81 |
| 336.40 | 2.68 | 2.68 |
| 382.37 | 1.99 | 1.99 |
| 279.34 | 2.12 | 2.12 |
| 249.31 | 2.11 | 2.11 |
| 310.83 | 4.02 | 4.02 |
| 357.49 | 3.34 | 3.34 |
| 207.27 | 1.52 | 1.52 |
| 200.28 | 2.11 | 2.11 |
| 242.30 | 3.52 | 3.52 |
| 473.41 | 7.49 | 7.49 |
| 525.64 | -0.65 | -0.65 |
| 179.22 | 0.91 | 0.91 |
| 223.28 | 2.52 | 2.52 |
| 249.22 | 2.39 | 2.39 |
| 259.26 | 2.79 | 2.79 |
| 294.38 | 1.83 | 1.83 |
| 322.80 | 2.42 | 2.42 |
| 306.34 | 1.91 | 1.91 |
| 278.40 | 3.02 | 3.02 |
| 381.39 | 2.60 | 2.60 |
| 363.40 | 2.46 | 2.46 |
| 213.24 | 2.11 | 2.11 |
| 426.56 | 3.96 | 3.96 |
| 533.74 | 4.62 | 4.62 |
| 349.41 | 0.32 | 0.32 |
| 556.77 | 7.05 | 7.05 |
| 373.42 | 4.32 | 4.32 |
| 375.43 | 4.98 | 4.98 |
| 296.42 | 4.17 | 4.17 |
| 411.46 | 6.06 | 6.06 |
| 314.39 | 2.47 | 2.47 |
| 314.35 | 1.22 | 1.22 |
| 315.33 | 0.78 | 0.78 |
| 307.40 | 2.64 | 2.64 |
| 364.83 | 5.21 | 5.21 |
| 364.83 | 5.21 | 5.21 |
| 398.38 | 5.58 | 5.58 |
| 225.21 | -1.33 | -1.33 |
| 488.40 | 2.91 | 2.91 |
| 461.54 | 1.10 | 1.10 |
| 175.24 | 2.14 | 2.14 |
| 166.25 | 1.28 | 1.28 |
| 118.14 | 1.56 | 1.56 |
| 433.50 | 2.52 | 2.52 |
| 421.56 | 5.45 | 5.45 |
| 409.96 | 5.15 | 5.15 |
| 409.51 | 4.76 | 4.76 |
| 402.97 | 4.42 | 4.42 |
| 400.99 | 4.83 | 4.83 |
| 401.98 | 3.69 | 3.69 |
| 444.02 | 3.46 | 3.46 |
| 280.37 | 2.64 | 2.64 |
| 265.34 | 3.24 | 3.24 |
| 479.53 | 3.68 | 3.68 |
| 428.54 | 4.78 | 4.78 |
| 253.26 | -0.90 | -0.90 |
| 378.41 | 2.37 | 2.37 |
| 316.43 | 2.19 | 2.19 |
| 155.63 | 1.84 | 1.84 |
| 166.18 | 1.10 | 1.10 |
| 128.20 | 1.17 | 1.17 |
| 403.95 | 3.81 | 3.81 |
| 388.94 | 3.09 | 3.09 |
| 435.01 | 4.03 | 4.03 |
| 437.58 | 3.35 | 3.35 |
| 388.94 | 3.09 | 3.09 |
| 479.40 | 5.54 | 5.54 |
| 201.29 | 3.37 | 3.37 |
| 220.28 | 3.48 | 3.48 |
| 205.30 | 2.60 | 2.60 |
| 558.60 | 4.17 | 4.17 |
| 519.57 | -0.71 | -0.71 |
| 513.68 | 5.95 | 5.95 |
| 254.29 | -0.19 | -0.19 |
| 356.33 | 2.73 | 2.73 |
| 247.30 | 2.72 | 2.72 |
| 280.33 | 1.82 | 1.82 |
| 283.76 | 2.77 | 2.77 |
| 182.25 | 1.23 | 1.23 |
| 423.90 | 3.66 | 3.66 |
| 346.22 | 3.60 | 3.60 |
| 175.19 | 1.43 | 1.43 |
| 244.29 | 2.72 | 2.72 |
| 346.84 | 4.27 | 4.27 |
| 228.29 | 3.01 | 3.01 |
| 214.27 | 2.71 | 2.71 |
| 240.33 | 3.86 | 3.86 |
| 264.33 | 3.86 | 3.86 |
| 455.47 | -0.62 | -0.62 |
| 279.38 | 3.96 | 3.96 |
| 485.37 | 5.46 | 5.46 |
| 499.39 | 5.33 | 5.33 |
| 499.96 | 3.05 | 3.05 |
| 424.91 | 2.31 | 2.31 |
| 422.40 | 3.13 | 3.13 |
| 452.96 | 2.84 | 2.84 |
| 423.92 | 3.24 | 3.24 |
| 416.91 | 3.08 | 3.08 |
| 286.76 | 3.68 | 3.68 |
| 261.35 | 2.79 | 2.79 |
| 251.29 | -1.00 | -1.00 |
| 282.17 | 4.07 | 4.07 |
| 198.27 | 3.00 | 3.00 |
| 149.15 | 1.18 | 1.18 |
| 243.26 | 2.40 | 2.40 |
| 252.75 | 2.98 | 2.98 |
| 302.83 | 4.39 | 4.39 |
| 300.79 | 3.94 | 3.94 |
| 304.75 | 3.82 | 3.82 |
| 312.25 | 2.43 | 2.43 |
| 334.34 | 4.31 | 4.31 |
| 296.37 | 3.30 | 3.30 |
| 283.40 | 3.44 | 3.44 |
| 434.97 | 2.65 | 2.65 |
| 244.29 | 3.33 | 3.33 |
| 226.30 | 3.19 | 3.19 |
| 500.43 | 3.73 | 3.73 |
| 551.46 | 3.88 | 3.88 |
| 401.37 | 3.18 | 3.18 |
| 311.77 | 3.22 | 3.22 |
| 343.41 | 2.67 | 2.67 |
| 469.95 | 5.16 | 5.16 |
| 527.48 | 5.52 | 5.52 |
| 492.62 | 2.81 | 2.81 |
| 516.47 | 5.12 | 5.12 |
| 505.49 | 5.55 | 5.55 |
| 463.41 | 5.13 | 5.13 |
| 477.43 | 5.37 | 5.37 |
| 463.41 | 5.45 | 5.45 |
| 463.41 | 5.45 | 5.45 |
| 463.41 | 5.45 | 5.45 |
| 477.43 | 5.38 | 5.38 |
| 493.43 | 5.22 | 5.22 |
| 477.43 | 5.45 | 5.45 |
| 477.43 | 5.45 | 5.45 |
| 477.43 | 5.45 | 5.45 |
| 491.46 | 5.24 | 5.24 |
| 491.46 | 5.24 | 5.24 |
| 512.46 | 3.98 | 3.98 |
| 423.34 | 4.28 | 4.28 |
| 507.41 | 4.60 | 4.60 |
| 477.39 | 4.84 | 4.84 |
| 501.42 | 4.32 | 4.32 |
| 512.46 | 4.40 | 4.40 |
| 530.45 | 4.54 | 4.54 |
| 546.90 | 5.05 | 5.05 |
| 542.49 | 4.41 | 4.41 |
| 555.53 | 4.47 | 4.47 |
| 526.49 | 4.71 | 4.71 |
| 555.53 | 4.47 | 4.47 |
| 540.51 | 5.02 | 5.02 |
| 463.32 | 3.08 | 3.08 |
| 371.44 | 3.49 | 3.49 |
| 324.82 | 3.80 | 3.80 |
| 381.43 | 3.49 | 3.49 |
| 378.43 | 2.99 | 2.99 |
| 481.30 | 3.37 | 3.37 |
| 508.32 | 3.33 | 3.33 |
| 487.91 | 2.99 | 2.99 |
| 522.35 | 3.35 | 3.35 |
| 490.39 | 3.47 | 3.47 |
| 484.41 | 3.05 | 3.05 |
| 440.55 | 4.89 | 4.89 |
| 500.36 | 5.15 | 5.15 |
| 545.93 | 5.59 | 5.59 |
| 524.96 | 4.07 | 4.07 |
| 740.76 | 1.54 | 1.54 |