Assay Report Card

Basic Information

ID: ALA3301365

Type: ADME

Description: ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole human plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound.

Organism: Homo sapiens

Tissue: Plasma

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
383.411.781.78
331.351.581.58
280.423.883.88
365.842.082.08
303.291.771.77
441.554.374.37
284.753.153.15
391.566.866.86
252.271.771.77
314.864.534.53
262.351.181.18
216.192.552.55
290.321.261.26
454.615.095.09
414.533.373.37
407.514.954.95
307.432.392.39
328.412.142.14
401.442.372.37
297.75-0.35-0.35
330.751.891.89
248.722.522.52
309.334.444.44
326.833.723.72
263.383.833.83
399.975.975.97
226.281.181.18
299.762.952.95
267.311.671.67
359.714.534.53
258.272.972.97
250.343.573.57
240.282.832.83
385.512.092.09
395.432.422.42
375.874.434.43
266.302.652.65
347.242.922.92
287.793.673.67
275.352.622.62
494.013.643.64
441.581.981.98
370.595.895.89
369.373.523.52
586.694.094.09
285.341.201.20
318.874.894.89
266.393.533.53
329.373.333.33
351.411.561.56
473.596.086.08
410.493.593.59
299.802.002.00
399.442.872.87
261.091.881.88
276.751.741.74
198.272.702.70
379.504.364.36
259.352.582.58
259.352.782.78
339.483.363.36
230.263.043.04
370.432.552.55
414.943.853.85
528.681.771.77
306.280.740.74
354.463.203.20
324.403.813.81
393.443.413.41
581.076.146.14
409.424.794.79
236.273.393.39
179.262.032.03
284.434.244.24
151.161.351.35
194.19-1.03-1.03
179.222.042.04
403.983.943.94
286.722.452.45
254.293.113.11
123.110.780.78
321.163.103.10
670.863.093.09
613.802.872.87
381.383.513.51
471.696.456.45
357.442.492.49
314.362.562.56
387.441.061.06
598.672.822.82
481.475.065.06
194.19-0.18-0.18
337.351.121.12
371.872.362.36
188.231.481.48
341.453.243.24
277.413.043.04
349.322.182.18
323.130.910.91
294.444.124.12
343.224.234.23
374.481.801.80
414.353.443.44
325.774.324.32
308.773.583.58
277.414.214.21
272.423.793.79
275.404.554.55
343.693.253.25
296.154.364.36
334.383.103.10
221.303.153.15
412.953.813.81
345.402.512.51
239.311.311.31
312.443.443.44
425.453.613.61
437.534.314.31
452.822.352.35
381.412.302.30
256.102.012.01
237.732.902.90
234.202.782.78
270.351.781.78
586.208.958.95
454.450.270.27
354.456.156.15
306.245.185.18
318.343.203.20
357.173.243.24
218.261.171.17
320.320.660.66
404.493.803.80
392.412.352.35
303.343.593.59
477.055.095.09
371.282.682.68
261.373.423.42
278.403.923.92
458.585.355.35
279.383.963.96
271.363.423.42
314.372.962.96
320.342.732.73
410.564.344.34
292.393.273.27
336.442.752.75
262.323.223.22
471.522.992.99
210.282.642.64
351.392.412.41
239.753.303.30
374.913.063.06
250.203.043.04
436.904.474.47
501.675.515.51
257.292.312.31
515.624.934.93
221.652.082.08
226.282.642.64
493.624.594.59
395.063.383.38
229.63-1.08-1.08
266.662.362.36
481.344.764.76
551.634.204.20
187.292.182.18
318.763.813.81
463.343.943.94
393.474.324.32
452.474.014.01
388.903.153.15
440.453.303.30
345.732.002.00
514.637.267.26
257.292.192.19
277.505.305.30
373.473.833.83
375.565.045.04
425.893.213.21
286.813.333.33
248.28-2.54-2.54
464.612.902.90
351.413.853.85
435.534.164.16
370.924.794.79
293.324.034.03
364.423.043.04
445.552.082.08
197.230.700.70
361.445.175.17
194.243.233.23
386.594.904.90
237.691.141.14
256.333.713.71
314.372.262.26
313.793.433.43
168.202.022.02
425.924.004.00
313.421.131.13
391.474.884.88
399.882.612.61
232.241.701.70
527.675.995.99
292.191.501.50
327.422.802.80
308.331.311.31
368.483.843.84
430.573.853.85
443.572.952.95
588.561.341.34
610.582.322.32
382.371.991.99
384.25
521.444.874.87
499.53-0.16-0.16
463.483.513.51
270.341.231.23
589.184.564.56
320.274.034.03
414.533.373.37
222.253.003.00
291.353.893.89
193.201.021.02
378.410.490.49
301.734.344.34
357.493.343.34
416.584.854.85
523.551.091.09
340.814.604.60
373.352.772.77
402.392.762.76
355.224.084.08
325.373.173.17
415.574.114.11
379.421.781.78
380.402.382.38
452.605.225.22
254.292.352.35
240.312.822.82
204.181.701.70
324.423.173.17
531.444.214.21
450.545.265.26
281.363.153.15
312.331.571.57
409.463.433.43
243.703.593.59
280.324.254.25
366.361.721.72
382.360.960.96
238.06
300.15
299.332.872.87
381.392.602.60
316.430.500.50
286.55
304.14
426.563.963.96
263.371.591.59
332.313.973.97
496.532.122.12
489.572.572.57
416.473.093.09
469.893.383.38
533.745.315.31
381.901.811.81
344.412.222.22
556.777.057.05
523.594.714.71
364.403.823.82
338.794.464.46
373.424.324.32
394.361.221.22
447.542.972.97
297.251.501.50
394.422.232.23
403.215.035.03
296.424.174.17
282.343.283.28
483.573.583.58
268.363.393.39
393.513.873.87
382.464.014.01
411.466.066.06
425.462.362.36
328.803.643.64
361.503.143.14
361.503.143.14
349.392.402.40
397.483.423.42
1024.20
314.351.221.22
388.403.763.76
480.592.702.70
514.442.482.48
468.644.644.64
509.553.233.23
481.582.092.09
492.602.762.76
510.622.062.06
435.594.614.61
315.330.780.78
340.342.582.58
485.634.174.17
360.443.823.82
307.402.642.64
451.920.090.09
422.322.222.22
422.322.222.22
422.322.222.22
344.414.874.87
364.835.215.21
348.384.704.70
360.414.574.57
408.483.963.96
355.404.434.43
380.834.784.78
380.834.914.91
364.835.215.21
344.414.874.87
398.385.585.58
398.385.585.58
340.334.454.45
505.621.861.86
568.685.945.94
259.302.842.84
482.015.255.25
612.885.005.00
408.463.583.58
407.322.022.02
425.923.353.35
397.432.902.90
418.452.972.97
392.471.901.90
367.834.764.76
493.593.573.57
488.402.912.91
494.572.312.31
511.522.782.78
483.551.631.63
512.591.611.61
510.592.902.90
461.541.101.10
339.474.104.10
278.312.872.87
469.543.963.96
362.234.064.06
420.472.032.03
388.403.763.76
454.52-0.64-0.64
376.403.973.97
285.312.662.66
299.372.802.80
316.323.333.33
213.241.361.36
180.17-1.04-1.04
389.823.683.68
430.415.525.52
505.662.962.96
586.616.536.53
603.605.815.81
517.075.595.59
348.372.272.27
308.333.613.61
434.903.083.08
413.482.392.39
383.453.033.03
423.514.024.02
439.513.003.00
439.564.664.66
337.432.352.35
387.963.703.70
402.974.424.42
402.974.424.42
400.994.834.83
401.983.693.69
413.993.833.83
371.532.942.94
444.023.463.46
458.003.103.10
500.584.434.43
489.602.932.93
244.251.321.32
459.564.884.88
328.393.123.12
297.383.533.53
265.343.243.24
511.956.126.12
352.143.713.71
474.591.611.61
408.355.005.00
415.544.564.56
439.565.045.04
549.594.894.89
313.272.122.12
396.521.211.21
456.571.971.97
546.522.792.79
576.552.562.56
435.484.294.29
408.882.272.27
315.465.565.56
304.322.982.98
348.454.674.67
346.342.182.18
114.170.710.71
170.241.381.38
411.635.005.00
553.595.255.25
636.714.704.70
399.453.243.24
428.493.093.09
400.442.492.49
268.653.273.27
469.573.663.66
299.772.432.43
439.523.823.82
378.324.454.45
437.500.900.90
465.354.944.94
308.322.382.38
277.271.151.15
376.424.384.38
297.382.972.97
351.382.722.72
490.824.534.53
403.412.552.55
379.392.082.08
461.542.822.82
378.412.372.37
366.402.302.30
494.993.353.35
369.502.232.23
338.412.062.06
348.452.462.46
366.442.602.60
347.472.752.75
492.663.773.77
308.382.572.57
217.290.630.63
614.225.025.02
361.440.380.38
358.472.992.99
419.795.265.26
386.244.894.89
425.825.325.32
392.274.954.95
385.884.924.92
419.435.285.28
505.533.563.56
439.855.635.63
406.295.265.26
457.845.775.77
424.285.405.40
281.322.772.77
343.424.054.05
491.945.315.31
468.506.406.40
451.553.893.89
360.372.572.57
438.522.572.57
259.352.582.58
427.894.934.93
397.503.163.16
389.344.824.82
426.482.272.27
362.431.901.90
380.422.042.04
422.462.352.35
445.512.952.95
437.523.683.68
437.523.683.68
441.483.513.51
488.424.924.92
455.513.893.89
337.383.403.40
471.964.414.41
488.424.924.92
504.424.164.16
471.513.133.13
487.963.653.65
467.553.303.30
467.553.303.30
355.373.543.54
359.333.373.37
355.373.543.54
460.374.144.14
460.374.144.14
460.374.144.14
427.463.123.12
462.913.183.18
430.344.144.14
430.344.144.14
430.344.144.14
397.433.113.11
448.334.284.28
448.354.374.37
488.425.295.29
415.423.253.25
448.354.374.37
488.425.295.29
462.384.764.76
488.424.924.92
502.455.315.31
488.424.924.92
415.443.343.34
455.514.264.26
457.483.113.11
415.443.343.34
504.423.903.90
518.454.554.55
502.404.454.45
525.574.634.63
518.403.423.42
455.513.903.90
469.544.284.28
455.513.903.90
428.443.593.59
442.473.723.72
467.524.044.04
481.554.434.43
457.944.024.02
474.394.534.53
457.944.024.02
311.862.482.48
433.825.575.57
428.494.704.70
447.934.934.93
448.835.155.15
400.223.173.17
251.292.372.37
211.313.103.10
314.773.613.61
453.614.254.25
314.773.613.61
408.453.023.02
485.562.012.01
263.344.054.05
404.563.943.94
381.442.072.07
448.492.572.57
340.453.473.47
427.46-0.54-0.54
645.68-1.11-1.11
388.833.763.76
346.804.224.22
176.180.080.08
479.943.463.46
357.373.673.67
373.824.184.18
481.922.822.82
392.833.493.49
264.333.663.66
274.323.793.79
406.453.073.07
391.742.782.78
422.786.706.70
441.414.884.88
476.555.295.29
478.643.093.09
463.553.833.83
569.585.195.19
234.312.712.71
422.573.773.77
409.453.803.80
392.465.285.28
405.242.202.20
423.945.655.65
421.973.033.03
428.924.004.00
378.445.275.27
348.384.314.31
212.211.301.30
392.841.391.39
424.813.853.85
501.514.104.10
474.505.105.10
437.583.353.35
568.596.686.68
550.606.546.54
419.953.373.37
424.935.055.05
401.894.524.52
567.067.057.05
361.472.062.06
414.892.522.52
415.265.195.19
461.513.613.61
419.502.192.19
419.502.192.19
341.39-0.48-0.48
518.603.933.93
394.785.015.01
391.785.385.38
581.475.755.75
364.393.403.40
327.373.273.27
339.342.232.23
353.372.532.53
313.342.962.96
314.332.352.35
352.383.143.14
338.352.832.83
353.363.113.11
353.363.113.11
244.302.372.37
256.312.152.15
258.311.661.66
231.261.251.25
294.814.174.17
331.403.013.01
355.441.091.09
321.833.673.67
130.10-0.20-0.20
416.814.754.75
450.355.045.04
326.784.584.58
386.452.382.38
460.626.146.14
252.343.853.85
429.482.692.69
360.413.053.05
434.483.063.06
331.383.093.09
361.413.103.10
416.492.922.92
428.543.443.44
415.503.533.53
426.483.093.09
427.472.492.49
248.251.801.80
389.463.683.68
414.472.982.98
362.381.601.60
625.675.815.81
311.412.182.18
520.893.923.92
1160.43
1159.45
1160.43
1160.43
1159.45
1105.31
404.323.623.62
477.314.434.43
383.473.863.86
490.564.204.20
475.543.873.87
470.604.784.78
777.891.921.92
362.842.822.82
360.832.582.58
312.323.663.66
355.401.201.20
330.444.564.56
358.495.345.34
491.755.415.41
323.372.982.98
616.505.555.55
251.332.992.99
330.394.894.89
350.423.973.97
471.55-0.73-0.73
318.442.462.46
421.474.524.52
491.615.395.39
397.442.772.77
507.534.284.28
400.503.063.06
182.251.231.23
234.282.302.30
442.602.312.31
374.474.364.36
386.913.883.88
423.903.663.66
461.593.753.75
617.774.644.64
358.221.381.38
501.035.425.42
196.16-0.40-0.40
518.49-1.41-1.41
439.385.765.76
429.605.415.41
339.404.234.23
388.443.503.50
382.493.233.23
382.493.233.23
388.443.503.50
404.904.024.02
370.453.373.37
404.904.024.02
395.492.332.33
355.262.322.32
414.513.863.86
405.953.613.61
384.483.953.95
311.340.830.83
458.955.355.35
346.223.603.60
418.524.914.91
449.354.944.94
449.543.173.17
311.413.503.50
338.484.694.69
312.393.733.73
326.742.882.88
454.943.733.73
403.834.414.41
235.672.932.93
351.372.602.60
372.453.893.89
297.342.462.46
285.252.452.45
282.301.501.50
359.863.243.24
290.392.492.49
266.381.311.31
410.511.521.52
388.394.224.22
311.373.553.55
245.282.612.61
255.363.953.95
394.503.493.49
228.283.063.06
274.281.031.03
230.271.611.61
248.293.493.49
281.381.291.29
230.152.282.28
331.793.903.90
440.623.713.71
353.433.023.02
365.412.662.66
278.701.671.67
309.764.114.11
249.323.433.43
287.263.843.84
427.462.882.88
242.303.373.37
366.804.124.12
357.424.414.41
292.343.433.43
377.853.693.69
474.364.594.59
330.412.362.36
418.501.141.14
355.183.143.14
416.532.982.98
307.393.093.09
295.401.021.02
454.572.182.18
340.464.374.37
336.393.963.96
214.272.152.15
281.312.752.75
309.283.033.03
253.262.812.81
480.592.622.62
388.312.992.99
331.793.903.90
325.154.344.34
396.312.972.97
426.503.023.02
325.322.062.06
305.292.802.80
318.423.713.71
332.454.024.02
463.385.435.43
314.864.074.07
280.310.870.87
208.241.921.92
249.383.253.25
197.260.670.67
332.453.743.74
396.313.243.24
321.334.214.21
213.282.892.89
292.343.323.32
318.383.933.93
339.402.632.63
362.433.183.18
303.163.303.30
306.363.853.85
307.402.992.99
342.400.400.40
221.652.322.32
219.271.561.56
422.754.274.27
376.844.524.52
424.502.572.57
352.372.452.45
379.463.543.54
412.262.982.98
400.273.073.07
341.593.023.02
179.262.692.69
415.863.023.02
318.343.203.20
322.224.764.76
320.483.603.60
279.383.963.96
220.292.982.98
442.323.773.77
485.375.465.46
257.322.952.95
227.292.942.94
434.925.095.09
361.423.043.04
312.374.184.18
328.373.673.67
332.322.492.49
358.363.063.06
364.772.712.71
374.813.583.58
328.362.662.66
349.762.972.97
409.222.822.82
393.223.123.12
377.822.762.76
361.362.252.25
399.432.192.19
417.422.332.33
433.882.842.84
415.431.891.89
433.422.032.03
449.882.542.54
375.433.693.69
355.501.681.68
479.584.594.59
420.374.704.70
360.322.772.77
356.362.942.94
356.362.942.94
376.783.283.28
393.233.803.80
442.472.902.90
438.513.073.07
438.513.073.07
458.933.423.42
428.442.512.51
424.482.682.68
424.482.682.68
444.903.033.03
640.826.976.97
378.394.324.32
424.912.312.31
438.932.452.45
452.962.842.84
442.902.452.45
438.932.702.70
438.932.702.70
452.963.093.09
416.913.083.08
434.903.223.22
451.353.733.73
465.384.124.12
351.411.281.28
472.593.453.45
402.411.171.17
276.343.613.61
302.363.253.25
309.372.522.52
282.753.333.33
511.653.813.81
378.424.934.93
571.784.234.23
476.583.153.15
490.613.463.46
504.643.853.85
386.453.673.67
394.504.494.49
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