Assay Report Card

Basic Information

ID: ALA3301366

Type: ADME

Description: ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole rat plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound.

Organism: Rattus norvegicus

Strain: SD, HW or BN

Tissue: Plasma

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
383.411.781.78
331.351.581.58
280.423.883.88
284.753.153.15
252.271.771.77
454.615.095.09
398.403.703.70
407.514.954.95
307.432.392.39
401.442.372.37
330.751.891.89
248.722.522.52
309.334.444.44
326.833.723.72
263.383.833.83
267.311.671.67
359.714.534.53
250.343.573.57
385.512.092.09
395.432.422.42
375.874.434.43
347.242.922.92
287.793.673.67
275.352.622.62
494.013.643.64
370.595.895.89
285.341.201.20
318.874.894.89
266.393.533.53
329.373.333.33
382.465.495.49
473.596.086.08
410.493.593.59
261.091.881.88
248.331.911.91
379.504.364.36
259.352.582.58
528.681.771.77
354.463.203.20
324.403.813.81
409.424.794.79
236.273.393.39
179.262.032.03
194.19-1.03-1.03
403.983.943.94
254.293.113.11
123.110.780.78
670.863.093.09
613.802.872.87
341.375.325.32
241.680.820.82
194.19-0.18-0.18
337.351.121.12
371.872.362.36
188.231.481.48
341.453.243.24
336.432.372.37
284.434.244.24
325.452.372.37
414.353.443.44
325.774.324.32
277.414.214.21
272.423.793.79
275.404.554.55
343.693.253.25
296.154.364.36
412.953.813.81
239.311.311.31
312.443.443.44
406.483.743.74
437.534.314.31
452.822.352.35
256.102.012.01
237.732.902.90
422.573.833.83
270.351.781.78
306.245.185.18
896.111.321.32
404.493.803.80
392.412.352.35
435.44-1.17-1.17
303.343.593.59
477.055.095.09
371.282.682.68
336.442.752.75
262.323.223.22
250.203.043.04
436.904.474.47
501.675.515.51
401.542.312.31
221.652.082.08
720.965.915.91
493.624.594.59
229.63-1.08-1.08
481.344.764.76
216.281.771.77
551.634.204.20
393.474.324.32
448.385.885.88
452.474.014.01
345.732.002.00
514.637.267.26
257.292.192.19
373.473.833.83
375.565.045.04
464.612.902.90
351.413.853.85
159.231.081.08
293.324.034.03
364.423.043.04
445.552.082.08
256.333.713.71
328.383.893.89
322.413.743.74
448.394.864.86
313.793.433.43
380.414.184.18
168.202.022.02
154.120.800.80
313.421.131.13
391.474.884.88
399.882.612.61
873.031.031.03
327.422.802.80
368.483.843.84
424.532.442.44
482.675.385.38
430.573.853.85
443.572.952.95
442.635.445.44
588.561.341.34
610.582.322.32
521.444.874.87
310.834.024.02
499.53-0.16-0.16
589.184.564.56
277.762.212.21
373.352.772.77
402.392.762.76
415.574.114.11
380.402.382.38
240.312.822.82
473.417.497.49
324.423.173.17
242.273.673.67
450.545.265.26
295.374.454.45
280.324.254.25
366.361.721.72
382.360.960.96
164.232.062.06
426.563.963.96
496.532.122.12
416.473.093.09
469.893.383.38
381.901.811.81
344.412.222.22
403.215.035.03
296.424.174.17
483.573.583.58
435.892.522.52
380.422.092.09
314.392.472.47
427.552.312.31
589.644.594.59
347.415.115.11
464.524.464.46
318.342.612.61
315.330.780.78
237.262.822.82
485.634.174.17
360.443.823.82
307.402.642.64
451.920.090.09
422.322.222.22
422.322.222.22
364.835.215.21
482.015.255.25
407.322.022.02
461.565.865.86
425.923.353.35
397.432.902.90
418.452.972.97
392.471.901.90
225.21-1.33-1.33
367.834.764.76
339.474.104.10
362.234.064.06
420.472.032.03
388.403.763.76
376.403.973.97
491.606.036.03
166.251.281.28
299.372.802.80
316.323.333.33
180.17-1.04-1.04
389.823.683.68
430.415.525.52
586.616.536.53
603.605.815.81
311.343.033.03
563.655.565.56
308.333.613.61
534.434.954.95
401.983.693.69
500.584.434.43
489.602.932.93
459.564.884.88
328.393.123.12
265.343.243.24
479.533.683.68
474.591.611.61
408.355.005.00
439.565.045.04
549.594.894.89
304.322.982.98
360.451.991.99
346.342.182.18
384.263.963.96
114.170.710.71
170.241.381.38
553.595.255.25
453.424.134.13
428.493.093.09
268.653.273.27
437.500.900.90
465.354.944.94
308.322.382.38
490.824.534.53
492.663.773.77
361.440.380.38
505.533.563.56
343.424.054.05
463.894.534.53
360.372.572.57
259.352.582.58
351.453.193.19
427.894.934.93
389.344.824.82
295.391.751.75
445.512.952.95
437.523.683.68
437.523.683.68
525.574.634.63
457.944.024.02
311.862.482.48
395.463.773.77
400.223.173.17
474.302.352.35
453.614.254.25
408.453.023.02
263.344.054.05
404.563.943.94
448.492.572.57
543.052.652.65
427.46-0.54-0.54
349.483.583.58
645.68-1.11-1.11
176.180.080.08
479.943.463.46
357.373.673.67
373.824.184.18
481.922.822.82
264.333.663.66
274.323.793.79
406.453.073.07
391.742.782.78
277.412.612.61
463.553.833.83
569.585.195.19
392.465.285.28
262.703.003.00
405.242.202.20
423.945.655.65
378.445.275.27
348.384.314.31
212.211.301.30
392.841.391.39
424.813.853.85
501.514.104.10
474.505.105.10
438.834.414.41
568.596.686.68
367.493.833.83
449.402.852.85
401.894.524.52
414.892.522.52
410.513.073.07
232.672.992.99
419.574.304.30
419.502.192.19
419.502.192.19
518.603.933.93
430.825.865.86
581.475.755.75
364.393.403.40
339.342.232.23
353.372.532.53
352.383.143.14
338.352.832.83
504.012.382.38
422.443.373.37
294.814.174.17
416.814.754.75
450.355.045.04
326.784.584.58
386.452.382.38
460.626.146.14
360.413.053.05
274.413.513.51
311.412.182.18
311.412.182.18
520.893.923.92
477.314.434.43
383.473.863.86
349.483.583.58
371.401.561.56
475.543.873.87
470.604.784.78
777.891.921.92
355.401.201.20
491.755.415.41
316.383.723.72
318.442.462.46
436.594.114.11
421.474.524.52
415.863.223.22
491.615.395.39
397.442.772.77
507.534.284.28
400.503.063.06
374.474.364.36
423.903.663.66
617.774.644.64
502.641.961.96
501.035.425.42
196.16-0.40-0.40
518.49-1.41-1.41
439.385.765.76
421.814.674.67
459.592.882.88
339.404.234.23
524.694.824.82
352.463.233.23
414.513.863.86
382.944.864.86
362.524.514.51
297.342.462.46
312.763.823.82
359.863.243.24
290.392.492.49
266.381.311.31
311.373.553.55
255.363.953.95
281.381.291.29
331.793.903.90
430.905.905.90
309.764.114.11
249.323.433.43
392.504.094.09
489.604.304.30
418.501.141.14
355.183.143.14
454.572.182.18
340.464.374.37
394.544.264.26
253.262.812.81
342.684.144.14
325.322.062.06
318.423.713.71
332.454.024.02
332.453.743.74
362.433.183.18
260.722.712.71
315.764.284.28
415.863.023.02
502.665.425.42
318.343.203.20
416.361.891.89
320.483.603.60
279.383.963.96
442.323.773.77
485.375.465.46
349.762.972.97
355.501.681.68
525.614.234.23
479.584.594.59
438.513.073.07
428.442.512.51
424.482.682.68
378.394.324.32
424.912.312.31
438.932.452.45
442.902.452.45
416.913.083.08
434.903.223.22
451.353.733.73
302.363.253.25
309.372.522.52
482.634.774.77
254.292.152.15
333.404.704.70
571.784.234.23
386.453.673.67
423.545.245.24
394.504.494.49
440.575.185.18
380.404.754.75
431.433.873.87
321.253.713.71
287.703.343.34
408.783.893.89
422.814.284.28
402.393.943.94
375.233.533.53
372.803.403.40
370.801.551.55
480.950.870.87
349.433.093.09
306.373.473.47
429.666.506.50
474.275.155.15
485.653.713.71
637.519.769.76
367.363.263.26
498.674.454.45
432.542.582.58
447.632.872.87
516.524.184.18
516.524.974.97
473.625.965.96
423.564.814.81
474.615.365.36
502.665.425.42
534.714.724.72
552.763.983.98
524.714.894.89
551.785.465.46
523.724.864.86
539.724.064.06
579.794.584.58
579.794.844.84
565.805.715.71
551.785.465.46
480.950.870.87
337.382.662.66
434.972.652.65
293.173.183.18
284.343.563.56
360.172.322.32
392.522.352.35
420.452.082.08
426.543.903.90
452.584.394.39
446.533.913.91
404.543.483.48
426.543.903.90
427.533.293.29
519.635.125.12
440.574.214.21
412.523.433.43
452.584.354.35
466.614.604.60
454.553.203.20
440.574.074.07
426.543.823.82
454.604.454.45
454.604.454.45
454.604.454.45
508.575.165.16
539.703.983.98
446.624.424.42
483.574.164.16
526.565.305.30
424.934.214.21
409.905.305.30
476.644.184.18
421.514.124.12
381.493.413.41
305.442.252.25
447.644.784.78
391.324.344.34
406.553.803.80
420.584.054.05
406.553.493.49
460.524.034.03
448.634.834.83
432.594.194.19
446.624.584.58
460.644.974.97
450.613.673.67
464.634.064.06
478.684.534.53
510.683.213.21
462.623.823.82
488.654.394.39
381.864.264.26
472.985.255.25
700.297.807.80
651.085.555.55
481.593.633.63
493.633.503.50
493.633.503.50
464.592.892.89
464.592.892.89
479.603.463.46
417.531.901.90
457.005.535.53
372.824.904.90
360.422.532.53
344.802.032.03
542.103.753.75
316.473.533.53
538.662.602.60
330.493.923.92
364.453.013.01
468.543.773.77
458.493.353.35
471.013.383.38
485.033.603.60
492.503.023.02
506.533.583.58
466.593.083.08
484.583.223.22
473.582.692.69
384.662.762.76
415.454.164.16
409.924.684.68
505.024.254.25
549.074.004.00
654.60-2.90-2.90
450.012.912.91
756.976.346.34
423.563.063.06
425.573.313.31
237.262.382.38
511.693.983.98
538.653.533.53
276.291.291.29
323.812.202.20
500.591.611.61
516.580.850.85
244.132.752.75
434.505.765.76
382.464.014.01
354.383.603.60
348.404.444.44
432.532.062.06
459.423.313.31
503.483.333.33
444.413.523.52
326.353.233.23
299.353.463.46
306.373.203.20
408.814.874.87
329.834.374.37
428.794.904.90
262.741.441.44
371.442.512.51
496.671.191.19
495.692.532.53
399.293.353.35
396.502.282.28
232.353.843.84
546.722.722.72
349.472.642.64
359.423.713.71
527.485.525.52
451.535.045.04
460.464.164.16
464.423.993.99
471.443.723.72
482.414.154.15
464.423.913.91
478.454.054.05
466.414.184.18
482.414.154.15
500.404.294.29
468.964.934.93
449.504.354.35
430.434.214.21
435.534.254.25
322.403.133.13
338.352.552.55
397.412.612.61
415.402.942.94
401.382.552.55
387.352.162.16
348.535.445.44
348.535.445.44
320.484.664.66
320.484.664.66
476.564.764.76
453.384.634.63
458.425.085.08
286.341.221.22
336.402.372.37
355.232.532.53
320.781.871.87
355.232.532.53
516.475.125.12
516.475.125.12
505.495.555.55
523.485.695.69
514.044.914.91
537.506.086.08
503.065.435.43
486.604.914.91
491.465.245.24
509.455.385.38
474.413.573.57
492.403.713.71
476.403.833.83
490.413.283.28
469.464.424.42
456.423.433.43
474.413.573.57
434.413.583.58
434.413.583.58
468.424.984.98
455.444.044.04
470.453.473.47
351.412.612.61
377.373.473.47
378.353.973.97
377.373.503.50
461.521.261.26
461.521.261.26
475.551.921.92
476.511.801.80
350.422.402.40
380.451.761.76
394.482.152.15
350.422.762.76
256.263.383.38
577.554.554.55
536.661.911.91
393.451.581.58
524.704.274.27
369.493.833.83
403.434.244.24
395.504.424.42
495.874.374.37
463.323.083.08
395.504.424.42
353.473.523.52
325.412.902.90
366.473.013.01
452.563.503.50
444.562.602.60
353.423.303.30
339.402.992.99
483.954.394.39
483.954.394.39
512.015.175.17
512.015.175.17
526.035.415.41
526.035.415.41
584.515.915.91
344.393.923.92
371.443.493.49
324.823.803.80
328.423.513.51
484.375.855.85
500.525.745.74
381.433.493.49
378.432.992.99
325.372.382.38
391.95
425.50
522.353.353.35
428.504.374.37
440.554.894.89
580.722.302.30
326.343.823.82
360.404.704.70
413.484.244.24
350.404.094.09
336.384.234.23
385.414.414.41
352.373.463.46
435.553.903.90
495.603.533.53
465.583.523.52
436.543.293.29
539.653.283.28
464.522.802.80
390.443.423.42
473.583.233.23
378.313.783.78
531.905.405.40
500.365.155.15
504.484.484.48
533.925.525.52
538.994.414.41
547.454.924.92
545.935.595.59
487.874.594.59
524.964.074.07
469.884.454.45
576.103.213.21
576.103.213.21
427.514.654.65
383.464.634.63
387.312.512.51
415.373.293.29
445.392.652.65
459.422.902.90
389.582.512.51
390.571.601.60
419.611.791.79
439.672.292.29
454.681.651.65
429.393.533.53
431.362.522.52
415.373.143.14
415.543.683.68