Basic Information
ID: ALA3301368
Type: ADME
Description: ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole mouse plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound.
Organism: Mus musculus
Tissue: Plasma
Activity Charts
Bioactivity
Activity Types for Assay ALA3301368
PPB
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 359.71 | 4.53 | 4.53 |
| 494.01 | 3.64 | 3.64 |
| 259.35 | 2.58 | 2.58 |
| 324.40 | 3.81 | 3.81 |
| 337.35 | 1.12 | 1.12 |
| 343.69 | 3.25 | 3.25 |
| 397.38 | 3.27 | 3.27 |
| 477.05 | 5.09 | 5.09 |
| 336.44 | 2.75 | 2.75 |
| 262.32 | 3.22 | 3.22 |
| 351.39 | 2.41 | 2.41 |
| 401.54 | 2.31 | 2.31 |
| 340.85 | 4.30 | 4.30 |
| 393.47 | 4.32 | 4.32 |
| 391.47 | 4.88 | 4.88 |
| 337.34 | 1.72 | 1.72 |
| 310.83 | 4.02 | 4.02 |
| 499.53 | -0.16 | -0.16 |
| 463.48 | 3.51 | 3.51 |
| 373.35 | 2.77 | 2.77 |
| 380.40 | 2.38 | 2.38 |
| 240.31 | 2.82 | 2.82 |
| 366.36 | 1.72 | 1.72 |
| 483.57 | 3.58 | 3.58 |
| 485.63 | 4.17 | 4.17 |
| 360.44 | 3.82 | 3.82 |
| 422.32 | 2.22 | 2.22 |
| 422.32 | 2.22 | 2.22 |
| 364.83 | 5.21 | 5.21 |
| 612.88 | 5.00 | 5.00 |
| 407.32 | 2.02 | 2.02 |
| 362.23 | 4.06 | 4.06 |
| 420.47 | 2.03 | 2.03 |
| 316.32 | 3.33 | 3.33 |
| 505.66 | 2.96 | 2.96 |
| 489.60 | 2.93 | 2.93 |
| 328.39 | 3.12 | 3.12 |
| 511.95 | 6.12 | 6.12 |
| 415.54 | 4.56 | 4.56 |
| 636.71 | 4.70 | 4.70 |
| 446.43 | 3.25 | 3.25 |
| 490.82 | 4.53 | 4.53 |
| 360.39 | 4.21 | 4.21 |
| 361.44 | 0.38 | 0.38 |
| 419.79 | 5.26 | 5.26 |
| 468.50 | 6.40 | 6.40 |
| 469.48 | 6.67 | 6.67 |
| 427.89 | 4.93 | 4.93 |
| 389.34 | 4.82 | 4.82 |
| 525.57 | 4.63 | 4.63 |
| 311.86 | 2.48 | 2.48 |
| 474.30 | 2.35 | 2.35 |
| 408.45 | 3.02 | 3.02 |
| 543.05 | 2.65 | 2.65 |
| 176.18 | 0.08 | 0.08 |
| 357.37 | 3.67 | 3.67 |
| 373.82 | 4.18 | 4.18 |
| 392.83 | 3.49 | 3.49 |
| 274.32 | 3.79 | 3.79 |
| 463.55 | 3.83 | 3.83 |
| 454.94 | 3.74 | 3.74 |
| 569.58 | 5.19 | 5.19 |
| 392.46 | 5.28 | 5.28 |
| 378.44 | 5.27 | 5.27 |
| 567.06 | 7.05 | 7.05 |
| 422.44 | 3.37 | 3.37 |
| 294.81 | 4.17 | 4.17 |
| 520.89 | 3.92 | 3.92 |
| 340.45 | 5.46 | 5.46 |
| 470.60 | 4.78 | 4.78 |
| 362.84 | 2.82 | 2.82 |
| 360.83 | 2.58 | 2.58 |
| 491.61 | 5.39 | 5.39 |
| 397.44 | 2.77 | 2.77 |
| 374.47 | 4.36 | 4.36 |
| 501.03 | 5.42 | 5.42 |
| 439.38 | 5.76 | 5.76 |
| 414.51 | 3.86 | 3.86 |
| 458.95 | 5.35 | 5.35 |
| 351.37 | 2.60 | 2.60 |
| 290.39 | 2.49 | 2.49 |
| 454.57 | 2.18 | 2.18 |
| 355.50 | 1.68 | 1.68 |
| 479.58 | 4.59 | 4.59 |
| 571.78 | 4.23 | 4.23 |
| 386.45 | 3.67 | 3.67 |
| 402.39 | 3.94 | 3.94 |
| 551.78 | 5.46 | 5.46 |
| 579.79 | 4.58 | 4.58 |
| 565.80 | 5.71 | 5.71 |
| 360.17 | 2.32 | 2.32 |
| 453.52 | 2.74 | 2.74 |
| 403.29 | 3.18 | 3.18 |
| 381.86 | 4.26 | 4.26 |
| 651.08 | 5.55 | 5.55 |
| 407.35 | 5.44 | 5.44 |
| 378.39 | 4.44 | 4.44 |
| 357.80 | 5.19 | 5.19 |
| 338.37 | 4.24 | 4.24 |
| 372.82 | 4.90 | 4.90 |
| 355.40 | 3.89 | 3.89 |
| 460.43 | 3.21 | 3.21 |
| 474.46 | 3.60 | 3.60 |
| 466.59 | 3.08 | 3.08 |
| 384.66 | 2.76 | 2.76 |
| 409.92 | 4.68 | 4.68 |
| 425.87 | 5.34 | 5.34 |
| 756.97 | 6.34 | 6.34 |
| 276.29 | 1.29 | 1.29 |
| 344.37 | 2.06 | 2.06 |
| 527.64 | 4.79 | 4.79 |
| 394.43 | 2.47 | 2.47 |
| 359.42 | 3.71 | 3.71 |
| 478.45 | 4.05 | 4.05 |
| 468.96 | 4.93 | 4.93 |
| 324.41 | 2.89 | 2.89 |
| 338.44 | 2.78 | 2.78 |
| 435.53 | 4.25 | 4.25 |
| 470.58 | 3.66 | 3.66 |
| 348.53 | 5.44 | 5.44 |
| 348.53 | 5.44 | 5.44 |
| 320.48 | 4.66 | 4.66 |
| 320.48 | 4.66 | 4.66 |
| 476.56 | 4.76 | 4.76 |
| 412.54 | 4.24 | 4.24 |
| 369.51 | 3.84 | 3.84 |
| 453.38 | 4.63 | 4.63 |
| 426.56 | 4.63 | 4.63 |
| 395.51 | 5.24 | 5.24 |
| 448.83 | 5.80 | 5.80 |
| 516.47 | 5.12 | 5.12 |
| 491.46 | 5.24 | 5.24 |
| 476.51 | 1.80 | 1.80 |
| 515.98 | 4.63 | 4.63 |
| 449.41 | 4.71 | 4.71 |
| 467.40 | 4.85 | 4.85 |
| 421.48 | 4.57 | 4.57 |
| 411.44 | 3.70 | 3.70 |
| 410.45 | 4.30 | 4.30 |
| 439.49 | 4.31 | 4.31 |
| 425.47 | 3.30 | 3.30 |
| 495.87 | 4.37 | 4.37 |
| 344.42 | 3.22 | 3.22 |
| 344.39 | 3.92 | 3.92 |
| 385.47 | 3.80 | 3.80 |
| 422.53 | 4.78 | 4.78 |
| 324.82 | 3.80 | 3.80 |
| 328.42 | 3.51 | 3.51 |
| 484.37 | 5.85 | 5.85 |
| 381.43 | 3.49 | 3.49 |
| 378.43 | 2.99 | 2.99 |
| 415.43 | 3.75 | 3.75 |
| 326.34 | 3.82 | 3.82 |
| 360.40 | 4.70 | 4.70 |
| 336.38 | 4.23 | 4.23 |
| 385.41 | 4.41 | 4.41 |
| 399.43 | 4.41 | 4.41 |
| 538.99 | 4.41 | 4.41 |
| 320.37 | 3.09 | 3.09 |
| 404.56 | 4.05 | 4.05 |
| 421.57 | 4.48 | 4.48 |