Basic Information
ID: ALA3301369
Type: ADME
Description: ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole guinea pig plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound.
Organism: Cavia porcellus
Strain: Dunkin Hartley
Tissue: Plasma
Activity Charts
Bioactivity
Activity Types for Assay ALA3301369
PPB
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 401.44 | 2.37 | 2.37 |
| 326.83 | 3.72 | 3.72 |
| 293.37 | 3.13 | 3.13 |
| 441.58 | 1.98 | 1.98 |
| 324.40 | 3.81 | 3.81 |
| 236.27 | 3.39 | 3.39 |
| 414.35 | 3.44 | 3.44 |
| 239.31 | 1.31 | 1.31 |
| 314.37 | 2.96 | 2.96 |
| 388.90 | 3.15 | 3.15 |
| 464.61 | 2.90 | 2.90 |
| 380.41 | 4.18 | 4.18 |
| 443.57 | 2.95 | 2.95 |
| 415.57 | 4.11 | 4.11 |
| 426.56 | 3.96 | 3.96 |
| 483.57 | 3.58 | 3.58 |
| 451.92 | 0.09 | 0.09 |
| 430.41 | 5.52 | 5.52 |
| 308.33 | 3.61 | 3.61 |
| 415.54 | 4.56 | 4.56 |
| 492.66 | 3.77 | 3.77 |
| 389.34 | 4.82 | 4.82 |
| 453.61 | 4.25 | 4.25 |
| 348.38 | 4.31 | 4.31 |
| 501.51 | 4.10 | 4.10 |
| 474.50 | 5.10 | 5.10 |
| 568.59 | 6.68 | 6.68 |
| 520.89 | 3.92 | 3.92 |
| 318.44 | 2.46 | 2.46 |
| 255.36 | 3.95 | 3.95 |
| 249.32 | 3.43 | 3.43 |
| 479.58 | 4.59 | 4.59 |
| 640.82 | 6.97 | 6.97 |
| 378.39 | 4.32 | 4.32 |
| 402.39 | 3.94 | 3.94 |
| 304.75 | 3.82 | 3.82 |
| 457.60 | 2.93 | 2.93 |
| 471.62 | 3.32 | 3.32 |
| 471.62 | 3.31 | 3.31 |
| 485.65 | 3.71 | 3.71 |
| 498.67 | 4.45 | 4.45 |
| 447.63 | 2.87 | 2.87 |
| 482.07 | 3.53 | 3.53 |
| 516.52 | 4.18 | 4.18 |
| 466.00 | 2.81 | 2.81 |
| 462.51 | 1.26 | 1.26 |
| 392.52 | 2.35 | 2.35 |
| 454.60 | 4.45 | 4.45 |
| 526.56 | 5.30 | 5.30 |
| 476.69 | 4.88 | 4.88 |
| 518.75 | 5.78 | 5.78 |
| 476.64 | 4.18 | 4.18 |
| 494.63 | 4.32 | 4.32 |
| 501.65 | 4.79 | 4.79 |
| 447.64 | 4.78 | 4.78 |
| 465.63 | 4.92 | 4.92 |
| 420.58 | 4.05 | 4.05 |
| 435.52 | 2.97 | 2.97 |
| 481.59 | 3.63 | 3.63 |
| 493.63 | 3.50 | 3.50 |
| 493.63 | 3.50 | 3.50 |
| 464.59 | 2.89 | 2.89 |
| 479.60 | 3.46 | 3.46 |
| 330.49 | 3.92 | 3.92 |
| 549.07 | 4.00 | 4.00 |
| 425.57 | 3.31 | 3.31 |
| 459.42 | 3.31 | 3.31 |
| 546.72 | 2.72 | 2.72 |
| 349.47 | 2.64 | 2.64 |
| 482.41 | 4.15 | 4.15 |
| 348.53 | 5.44 | 5.44 |
| 320.48 | 4.66 | 4.66 |
| 320.48 | 4.66 | 4.66 |
| 476.56 | 4.76 | 4.76 |
| 412.54 | 4.24 | 4.24 |
| 505.49 | 5.55 | 5.55 |
| 491.46 | 5.24 | 5.24 |
| 476.51 | 1.80 | 1.80 |
| 577.55 | 4.55 | 4.55 |
| 500.43 | 4.98 | 4.98 |
| 393.45 | 1.58 | 1.58 |
| 500.52 | 5.74 | 5.74 |
| 490.39 | 3.47 | 3.47 |
| 326.34 | 3.82 | 3.82 |
| 413.48 | 4.24 | 4.24 |
| 350.40 | 4.09 | 4.09 |
| 336.38 | 4.23 | 4.23 |
| 385.41 | 4.41 | 4.41 |
| 352.37 | 3.46 | 3.46 |
| 399.43 | 4.41 | 4.41 |
| 337.36 | 3.62 | 3.62 |