Assay Report Card

Basic Information

ID: ALA3301370

Type: ADME

Description: ASTRAZENECA: Intrinsic clearance measured in human liver microsomes following incubation at 37C. Experimental range <3 to >150 microL/min/mg. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736.

Organism: Homo sapiens

Tissue: Liver

Subcellular Fraction: Microsome

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
232.241.421.42
280.423.883.88
441.554.374.37
284.753.153.15
262.351.181.18
216.192.552.55
290.321.261.26
454.615.095.09
414.533.373.37
334.213.713.71
307.432.392.39
330.751.891.89
253.281.371.37
326.833.723.72
263.383.833.83
299.762.952.95
267.311.671.67
331.183.753.75
250.343.573.57
293.373.133.13
218.211.981.98
385.512.092.09
375.874.434.43
494.013.643.64
370.595.895.89
586.694.094.09
318.874.894.89
266.393.533.53
351.411.561.56
473.596.086.08
198.272.702.70
168.202.722.72
309.413.423.42
274.803.823.82
259.352.782.78
354.463.203.20
393.443.413.41
581.076.146.14
236.273.393.39
244.263.683.68
151.161.351.35
179.222.042.04
356.424.374.37
321.163.103.10
670.863.093.09
471.696.456.45
598.672.822.82
481.475.065.06
295.411.321.32
645.326.946.94
389.553.633.63
336.432.372.37
414.353.443.44
275.404.554.55
477.575.285.28
355.875.185.18
296.154.364.36
241.293.753.75
334.383.103.10
249.301.461.46
239.311.311.31
406.483.743.74
381.354.684.68
322.394.084.08
270.351.781.78
586.208.958.95
291.381.221.22
230.263.043.04
354.456.156.15
357.173.243.24
218.261.171.17
479.501.351.35
263.793.963.96
392.412.352.35
477.055.095.09
369.473.653.65
278.403.923.92
458.585.355.35
470.616.336.33
271.363.423.42
375.214.824.82
271.353.263.26
239.753.303.30
319.413.053.05
501.675.515.51
395.063.383.38
229.63-1.08-1.08
266.662.362.36
481.344.764.76
260.313.173.17
551.634.204.20
302.142.792.79
463.343.943.94
452.474.014.01
388.903.153.15
354.454.614.61
133.151.151.15
440.464.034.03
514.637.267.26
254.293.113.11
257.292.192.19
153.140.510.51
248.311.681.68
464.612.902.90
390.473.793.79
250.312.582.58
281.383.723.72
361.443.363.36
435.534.164.16
293.324.034.03
364.423.043.04
194.243.233.23
332.363.943.94
237.691.141.14
150.211.881.88
349.434.864.86
292.321.611.61
425.924.004.00
413.913.923.92
232.241.701.70
373.413.063.06
527.675.995.99
225.251.681.68
280.333.493.49
873.031.031.03
347.465.405.40
368.483.843.84
424.532.442.44
478.643.213.21
557.722.282.28
416.543.513.51
416.543.513.51
482.675.385.38
430.573.853.85
443.572.952.95
493.652.722.72
414.574.664.66
428.564.224.22
442.635.445.44
429.542.612.61
457.603.293.29
311.382.812.81
336.402.682.68
279.342.122.12
436.275.495.49
499.595.165.16
222.253.003.00
277.762.212.21
229.281.211.21
243.311.601.60
322.212.322.32
291.353.893.89
262.220.840.84
318.853.873.87
303.834.294.29
193.201.021.02
313.444.554.55
313.444.554.55
417.515.055.05
378.410.490.49
252.273.013.01
523.551.091.09
349.391.871.87
355.224.084.08
461.472.642.64
325.373.173.17
415.574.114.11
204.181.701.70
282.340.080.08
242.273.673.67
582.376.306.30
238.06
300.15
255.11
278.403.023.02
286.55
426.563.963.96
263.371.591.59
496.532.122.12
416.473.093.09
469.893.383.38
505.684.024.02
530.735.335.33
518.725.175.17
485.635.675.67
486.665.395.39
483.665.335.33
444.595.515.51
533.745.315.31
455.655.905.90
332.341.301.30
344.412.222.22
522.615.315.31
530.674.874.87
453.544.484.48
523.594.714.71
528.635.375.37
169.571.771.77
364.403.823.82
338.794.464.46
373.424.324.32
450.524.334.33
390.425.065.06
453.524.394.39
375.434.984.98
254.293.113.11
297.251.501.50
394.422.232.23
375.351.091.09
216.240.890.89
403.215.035.03
296.424.174.17
284.362.502.50
268.363.393.39
382.464.014.01
411.466.066.06
402.454.674.67
475.985.475.47
425.462.362.36
575.785.135.13
617.866.156.15
611.834.544.54
593.775.275.27
532.755.485.48
543.735.045.04
596.824.574.57
328.803.643.64
497.506.236.23
326.352.942.94
361.503.143.14
270.382.662.66
290.372.672.67
397.483.423.42
397.483.423.42
371.371.561.56
371.371.561.56
314.392.472.47
374.444.254.25
392.434.394.39
346.392.772.77
314.351.221.22
183.10-0.60-0.60
480.592.702.70
470.585.535.53
468.644.644.64
493.554.264.26
492.602.762.76
496.626.066.06
509.553.233.23
252.732.752.75
315.330.780.78
340.342.582.58
395.422.532.53
237.262.822.82
649.255.365.36
650.794.994.99
596.824.574.57
614.814.714.71
614.814.714.71
631.265.225.22
307.402.642.64
523.550.660.66
344.414.874.87
364.835.215.21
348.384.704.70
360.414.574.57
408.483.963.96
355.404.434.43
380.834.784.78
380.834.914.91
364.835.215.21
344.414.874.87
398.385.585.58
398.385.585.58
398.385.585.58
340.334.454.45
568.685.945.94
259.302.842.84
397.432.902.90
529.562.782.78
488.402.912.91
494.572.312.31
512.591.611.61
461.541.101.10
339.474.104.10
278.312.872.87
420.472.032.03
388.403.763.76
491.606.036.03
555.527.137.13
267.333.593.59
180.17-1.04-1.04
586.616.536.53
374.363.983.98
388.384.284.28
374.363.983.98
388.384.284.28
421.565.455.45
409.965.155.15
409.514.764.76
308.333.613.61
434.903.083.08
423.514.024.02
439.513.003.00
439.564.664.66
365.462.892.89
337.432.352.35
368.512.522.52
387.963.703.70
402.974.424.42
401.983.693.69
413.993.833.83
444.023.463.46
280.372.642.64
265.343.243.24
352.143.713.71
474.591.611.61
396.521.211.21
486.601.741.74
442.551.721.72
510.542.512.51
424.544.354.35
348.454.674.67
346.342.182.18
428.544.784.78
170.241.381.38
399.453.243.24
453.424.134.13
428.493.093.09
400.442.492.49
393.443.003.00
279.302.142.14
299.772.432.43
297.27-1.97-1.97
465.354.944.94
308.322.382.38
261.312.002.00
376.424.384.38
297.382.972.97
299.763.003.00
172.191.371.37
351.382.722.72
331.401.731.73
378.402.682.68
379.392.082.08
378.412.372.37
494.993.353.35
437.543.583.58
369.502.232.23
338.412.062.06
348.452.462.46
366.442.602.60
400.893.263.26
316.432.192.19
245.270.690.69
492.663.773.77
487.044.084.08
308.382.572.57
360.394.214.21
348.431.951.95
362.462.342.34
335.392.032.03
348.431.741.74
343.424.054.05
360.372.572.57
280.314.104.10
309.414.114.11
426.482.272.27
513.652.152.15
445.512.952.95
419.552.132.13
402.521.801.80
459.533.383.38
437.523.683.68
462.913.183.18
424.533.523.52
314.773.613.61
314.773.613.61
404.563.943.94
381.442.072.07
349.483.583.58
406.453.073.07
466.514.884.88
476.555.295.29
414.484.004.00
466.513.733.73
470.503.633.63
500.523.473.47
490.923.973.97
490.923.973.97
478.643.093.09
486.502.812.81
361.873.853.85
435.614.604.60
375.904.594.59
441.534.704.70
423.945.655.65
388.943.093.09
302.814.204.20
348.384.314.31
392.841.391.39
424.813.853.85
435.014.034.03
404.983.753.75
417.004.094.09
402.973.613.61
421.893.383.38
479.883.503.50
501.514.104.10
438.834.414.41
437.583.353.35
497.084.544.54
282.394.394.39
367.493.833.83
449.402.852.85
424.935.055.05
549.124.154.15
401.894.524.52
414.892.522.52
410.513.073.07
470.015.405.40
378.862.522.52
419.574.304.30
388.943.093.09
474.996.206.20
415.265.195.19
383.500.660.66
500.365.435.43
194.262.282.28
518.603.933.93
207.261.291.29
581.475.755.75
364.393.403.40
313.342.962.96
314.332.352.35
352.464.004.00
258.311.661.66
272.712.442.44
331.403.013.01
321.833.673.67
386.452.382.38
282.373.763.76
252.343.853.85
479.405.545.54
409.421.651.65
248.251.801.80
625.675.815.81
311.412.182.18
406.391.941.94
404.323.623.62
383.473.863.86
490.564.204.20
349.483.583.58
371.401.561.56
370.455.865.86
421.504.824.82
378.523.853.85
378.523.853.85
700.797.587.58
355.401.201.20
326.382.532.53
319.393.603.60
333.423.643.64
302.383.783.78
330.444.564.56
358.495.345.34
312.423.283.28
267.242.502.50
491.636.186.18
473.646.046.04
438.553.763.76
491.755.415.41
316.383.723.72
323.372.982.98
616.505.555.55
484.664.674.67
154.262.092.09
350.423.973.97
557.610.830.83
318.442.462.46
436.594.114.11
421.474.524.52
415.863.223.22
357.254.464.46
373.254.164.16
522.643.623.62
283.762.772.77
400.503.063.06
182.251.231.23
234.282.302.30
285.232.332.33
423.903.663.66
617.774.644.64
358.221.381.38
518.49-1.41-1.41
429.605.415.41
366.812.892.89
405.953.613.61
382.944.864.86
362.524.514.51
311.340.830.83
383.125.395.39
420.403.393.39
346.223.603.60
416.533.923.92
418.524.914.91
343.412.992.99
449.543.173.17
372.453.893.89
484.516.256.25
236.283.223.22
268.272.862.86
388.394.224.22
344.402.392.39
394.503.493.49
248.293.493.49
344.453.823.82
440.623.713.71
424.303.693.69
353.433.023.02
346.844.274.27
241.323.253.25
236.301.041.04
388.313.623.62
311.414.274.27
366.224.564.56
397.532.712.71
254.313.553.55
392.504.094.09
361.433.373.37
330.412.362.36
269.262.262.26
416.532.982.98
336.223.353.35
307.393.093.09
295.401.021.02
340.464.374.37
393.523.133.13
280.333.493.49
281.312.752.75
285.332.962.96
299.333.473.47
480.592.622.62
426.503.023.02
278.342.122.12
284.721.791.79
351.843.663.66
249.383.253.25
197.260.670.67
177.231.791.79
321.334.214.21
213.282.892.89
292.343.323.32
367.853.413.41
318.383.933.93
339.402.632.63
307.402.992.99
345.453.113.11
221.652.322.32
276.344.794.79
334.281.821.82
352.372.452.45
379.463.543.54
315.764.284.28
179.262.692.69
415.863.023.02
413.274.774.77
218.262.962.96
485.375.465.46
499.395.505.50
499.395.335.33
237.334.394.39
221.264.034.03
257.322.952.95
227.292.942.94
434.925.095.09
361.423.043.04
293.331.881.88
423.132.432.43
522.504.844.84
428.442.512.51
640.826.976.97
348.405.085.08
424.912.312.31
458.462.682.68
438.932.452.45
422.403.133.13
438.932.702.70
452.962.842.84
423.923.243.24
442.902.452.45
438.932.702.70
438.932.702.70
438.932.702.70
452.963.093.09
466.993.483.48
430.933.473.47
416.913.083.08
434.903.223.22
451.353.733.73
451.353.733.73
451.353.733.73
465.384.124.12
466.993.483.48
435.353.903.90
414.933.633.63
436.963.003.00
472.593.453.45
309.372.522.52
286.763.683.68
511.653.813.81
254.292.152.15
284.362.682.68
333.404.704.70
469.575.315.31
368.422.382.38
396.473.163.16
423.545.245.24
394.504.494.49
327.412.582.58
365.914.504.50
440.575.185.18
424.534.644.64
424.534.644.64
335.204.054.05
273.242.732.73
307.143.583.58
311.363.943.94
253.262.692.69
243.262.402.40
374.343.243.24
356.374.954.95
431.433.873.87
330.694.494.49
326.273.843.84
403.383.233.23
321.253.713.71
388.363.633.63
372.345.505.50
417.413.543.54
339.243.853.85
335.284.024.02
287.703.343.34
408.783.893.89
422.814.284.28
402.393.943.94
354.813.263.26
375.233.533.53
334.392.782.78
372.803.403.40
368.843.573.57
389.263.923.92
422.814.284.28
416.424.334.33
400.424.494.49
401.413.343.34
362.821.881.88
370.801.551.55
480.950.870.87
349.433.093.09
311.351.771.77
403.443.073.07
252.752.982.98
304.753.823.82
312.252.432.43
334.344.314.31
296.373.303.30
283.403.443.44
286.763.683.68
314.411.461.46
459.572.032.03
333.192.912.91
268.322.462.46
457.602.932.93
471.623.323.32
471.623.313.31
485.653.713.71
501.653.203.20
306.284.614.61
448.613.303.30
448.613.303.30
498.674.454.45
432.542.582.58
482.603.743.74
447.632.872.87
475.683.443.44
491.683.273.27
515.623.893.89
482.073.533.53
516.524.184.18
482.073.533.53
482.073.533.53
516.524.184.18
466.002.812.81
466.633.023.02
542.446.976.97
524.645.315.31
455.485.955.95
455.485.955.95
626.605.695.69
267.332.072.07
355.392.402.40
261.312.002.00
391.474.154.15
337.382.662.66
434.972.652.65
375.454.184.18
293.173.183.18
332.403.503.50
284.343.563.56
328.373.173.17
440.514.224.22
419.744.584.58
298.424.124.12
358.474.144.14
217.180.050.05
376.452.602.60
392.522.352.35
316.291.681.68
426.543.903.90
370.432.342.34
438.554.044.04
452.584.394.39
446.533.913.91
404.543.483.48
427.533.293.29
426.543.903.90
460.994.554.55
427.533.293.29
440.573.963.96
364.472.452.45
479.564.254.25
519.635.125.12
440.574.214.21
412.523.433.43
452.584.354.35
466.614.694.69
452.584.294.29
466.614.604.60
454.553.203.20
440.574.074.07
426.543.823.82
454.604.454.45
454.604.454.45
454.604.454.45
508.575.165.16
539.703.983.98
446.624.424.42
459.553.683.68
483.574.164.16
526.565.305.30
345.855.155.15
366.275.495.49
380.306.056.05
390.304.974.97
366.275.495.49
366.275.495.49
366.275.495.49
349.814.984.98
363.845.295.29
391.285.365.36
409.924.244.24
409.924.244.24
409.924.244.24
416.935.215.21
388.884.204.20
388.884.804.80
407.926.516.51
407.926.516.51
409.905.305.30
345.855.155.15
345.855.155.15
389.503.903.90
341.434.504.50
361.854.164.16
377.853.833.83
381.813.663.66
373.433.183.18
420.873.483.48
456.932.892.89
333.754.624.62
408.863.853.85
441.434.644.64
422.894.244.24
346.844.544.54
486.685.265.26
462.664.574.57
476.694.884.88
463.653.963.96
517.766.396.39
518.755.785.78
498.095.275.27
495.665.155.15
491.704.804.80
476.644.184.18
494.634.324.32
477.633.573.57
478.622.972.97
488.655.195.19
500.665.405.40
501.654.794.79
498.610.900.90
637.858.988.98
381.493.413.41
305.442.252.25
425.644.904.90
447.644.784.78
465.634.924.92
251.292.672.67
241.292.962.96
391.324.344.34
406.553.803.80
406.553.493.49
460.524.034.03
434.614.224.22
448.634.834.83
432.594.194.19
446.624.584.58
460.644.974.97
450.613.673.67
464.634.064.06
478.684.534.53
510.683.213.21
475.663.733.73
543.664.664.66
462.623.823.82
488.654.394.39
700.297.807.80
305.142.442.44
278.682.472.47
651.085.555.55
569.666.156.15
498.054.154.15
481.593.633.63
481.593.633.63
493.633.503.50
493.633.503.50
516.674.284.28
464.592.892.89
481.593.633.63
477.633.883.88
479.603.463.46
484.024.104.10
479.603.463.46
479.603.463.46
493.633.853.85
493.633.803.80
497.593.473.47
493.633.503.50
264.283.193.19
503.674.544.54
539.705.685.68
532.494.804.80
454.662.822.82
479.562.722.72
609.506.766.76
602.854.904.90
658.813.543.54
567.804.384.38
615.886.036.03
603.853.793.79
657.824.684.68
640.822.932.93
631.914.414.41
671.854.814.81
672.745.105.10
368.554.424.42
417.513.763.76
409.492.812.81
420.903.543.54
316.473.533.53
330.493.923.92
272.291.631.63
374.663.313.31
384.662.762.76
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431.542.732.73
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521.495.255.25
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