Assay Report Card

Basic Information

ID: ALA3301371

Type: ADME

Description: ASTRAZENECA: Intrinsic clearance measured in rat hepatocytes following incubation at 37C. Experimental range <3 to >150 microL/min/1E6 cells. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736

Organism: Rattus norvegicus

Strain: CD1, BC, CD1, NMRI, SCID, or Nd

Tissue: Liver

Cell type: Hepatocyte

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
383.411.781.78
280.423.883.88
365.842.082.08
441.554.374.37
249.352.152.15
914.196.186.18
262.351.181.18
216.192.552.55
454.615.095.09
414.533.373.37
307.432.392.39
253.281.371.37
326.833.723.72
263.383.833.83
226.281.181.18
267.311.671.67
331.183.753.75
250.343.573.57
395.432.422.42
375.874.434.43
441.581.981.98
267.25-1.98-1.98
370.595.895.89
586.694.094.09
318.874.894.89
266.393.533.53
351.411.561.56
473.596.086.08
421.451.851.85
248.331.911.91
309.413.423.42
274.803.823.82
308.383.793.79
354.463.203.20
393.443.413.41
581.076.146.14
236.273.393.39
151.161.351.35
194.19-1.03-1.03
179.222.042.04
254.293.113.11
321.163.103.10
670.863.093.09
613.802.872.87
210.261.211.21
471.696.456.45
598.672.822.82
188.231.481.48
295.411.321.32
645.326.946.94
389.553.633.63
323.130.910.91
336.432.372.37
325.452.372.37
343.224.234.23
374.481.801.80
414.353.443.44
325.774.324.32
308.773.583.58
171.160.090.09
360.844.684.68
296.154.364.36
161.161.871.87
267.283.453.45
239.311.311.31
381.354.684.68
304.353.813.81
270.351.781.78
586.208.958.95
354.456.156.15
357.173.243.24
218.261.171.17
263.793.963.96
392.412.352.35
477.055.095.09
369.473.653.65
261.373.423.42
278.403.923.92
470.616.336.33
271.353.263.26
239.753.303.30
250.203.043.04
269.393.663.66
319.413.053.05
501.675.515.51
395.063.383.38
229.63-1.08-1.08
266.662.362.36
481.344.764.76
260.313.173.17
318.372.992.99
270.213.253.25
301.144.224.22
452.474.014.01
354.454.614.61
349.770.710.71
440.464.034.03
254.293.113.11
257.292.192.19
360.412.362.36
248.28-2.54-2.54
361.44-2.01-2.01
464.612.902.90
435.534.164.16
364.423.043.04
365.410.020.02
332.363.943.94
237.691.141.14
349.434.864.86
232.241.701.70
527.675.995.99
225.251.681.68
280.333.493.49
347.465.405.40
368.483.843.84
424.532.442.44
557.722.282.28
416.543.513.51
416.543.513.51
430.573.853.85
443.572.952.95
493.652.722.72
414.574.664.66
428.564.224.22
442.635.445.44
429.542.612.61
457.603.293.29
304.334.014.01
310.834.024.02
244.300.250.25
589.184.564.56
291.353.893.89
378.410.490.49
252.273.013.01
523.551.091.09
349.391.871.87
355.224.084.08
461.472.642.64
415.574.114.11
304.274.334.33
204.181.701.70
324.423.173.17
280.324.254.25
238.06
300.15
255.11
316.430.500.50
286.55
426.563.963.96
263.371.591.59
510.647.467.46
496.532.122.12
416.473.093.09
469.893.383.38
332.341.301.30
528.635.375.37
190.202.192.19
254.293.113.11
297.251.501.50
394.422.232.23
375.351.091.09
403.215.035.03
382.464.014.01
411.466.066.06
475.985.475.47
425.462.362.36
328.803.643.64
497.506.236.23
371.371.561.56
374.444.254.25
392.434.394.39
388.403.763.76
183.10-0.60-0.60
331.383.883.88
340.342.582.58
395.422.532.53
237.262.822.82
632.804.854.85
307.402.642.64
340.334.454.45
568.685.945.94
259.302.842.84
573.716.906.90
488.023.313.31
397.432.902.90
392.471.901.90
339.474.104.10
813.457.887.88
278.312.872.87
388.403.763.76
205.170.300.30
555.527.137.13
267.333.593.59
180.17-1.04-1.04
586.616.536.53
603.605.815.81
421.565.455.45
409.965.155.15
409.514.764.76
486.413.343.34
413.482.392.39
383.453.033.03
365.462.892.89
697.784.754.75
401.983.693.69
444.023.463.46
500.584.434.43
459.564.884.88
280.372.642.64
265.343.243.24
479.533.683.68
474.591.611.61
424.544.354.35
348.454.674.67
346.342.182.18
428.544.784.78
371.392.582.58
399.453.243.24
453.424.134.13
428.493.093.09
400.442.492.49
393.443.003.00
299.772.432.43
297.27-1.97-1.97
437.500.900.90
317.394.494.49
465.354.944.94
308.322.382.38
297.382.972.97
172.191.371.37
379.392.082.08
494.993.353.35
437.543.583.58
338.412.062.06
348.452.462.46
366.442.602.60
400.893.263.26
316.432.192.19
245.270.690.69
492.663.773.77
487.044.084.08
360.394.214.21
488.574.444.44
343.424.054.05
360.372.572.57
426.482.272.27
392.462.502.50
513.652.152.15
445.512.952.95
402.521.801.80
437.523.683.68
462.913.183.18
314.773.613.61
363.390.150.15
314.773.613.61
404.563.943.94
381.442.072.07
532.583.403.40
427.46-0.54-0.54
974.638.838.83
349.483.583.58
645.68-1.11-1.11
406.453.073.07
207.231.331.33
466.514.884.88
476.555.295.29
414.484.004.00
466.513.733.73
470.503.633.63
500.523.473.47
490.923.973.97
490.923.973.97
478.643.093.09
486.502.812.81
361.873.853.85
262.703.003.00
405.242.202.20
441.534.704.70
423.945.655.65
388.943.093.09
348.384.314.31
392.841.391.39
424.813.853.85
417.004.094.09
421.893.383.38
479.883.503.50
501.514.104.10
438.834.414.41
437.583.353.35
367.493.833.83
449.402.852.85
424.935.055.05
549.124.154.15
401.894.524.52
414.892.522.52
410.513.073.07
470.015.405.40
232.672.992.99
419.574.304.30
415.265.195.19
461.513.613.61
383.500.660.66
500.365.435.43
194.262.282.28
518.603.933.93
581.475.755.75
364.393.403.40
352.464.004.00
424.353.913.91
272.712.442.44
321.833.673.67
386.452.382.38
479.405.545.54
409.421.651.65
248.251.801.80
414.472.982.98
625.675.815.81
311.412.182.18
1160.43
1159.45
1160.43
1160.43
1159.45
1105.31
406.391.941.94
404.323.623.62
383.473.863.86
349.483.583.58
371.401.561.56
515.614.834.83
370.455.865.86
421.504.824.82
378.523.853.85
378.523.853.85
390.244.344.34
390.254.344.34
355.401.201.20
438.553.763.76
491.755.415.41
316.383.723.72
532.574.464.46
323.372.982.98
616.505.555.55
484.664.674.67
350.423.973.97
557.610.830.83
1030.30
318.442.462.46
436.594.114.11
421.474.524.52
415.863.223.22
357.254.464.46
373.254.164.16
397.442.772.77
507.534.284.28
522.643.623.62
400.503.063.06
494.984.554.55
285.232.332.33
423.903.663.66
425.492.252.25
461.593.753.75
617.774.644.64
358.221.381.38
380.451.801.80
518.49-1.41-1.41
486.583.543.54
366.812.892.89
405.953.613.61
382.944.864.86
362.524.514.51
311.340.830.83
383.125.395.39
416.533.923.92
418.524.914.91
343.412.992.99
449.543.173.17
372.453.893.89
484.516.256.25
236.283.223.22
268.272.862.86
388.394.224.22
344.402.392.39
394.503.493.49
248.293.493.49
440.623.713.71
424.303.693.69
353.433.023.02
346.844.274.27
241.323.253.25
388.313.623.62
366.224.564.56
397.532.712.71
254.313.553.55
392.504.094.09
292.343.433.43
361.433.373.37
330.412.362.36
269.262.262.26
416.532.982.98
336.223.353.35
295.401.021.02
340.464.374.37
393.523.133.13
280.333.493.49
267.293.783.78
281.312.752.75
285.332.962.96
299.333.473.47
480.592.622.62
426.503.023.02
278.342.122.12
284.721.791.79
249.383.253.25
197.260.670.67
284.361.041.04
321.334.214.21
213.282.892.89
292.343.323.32
367.853.413.41
318.383.933.93
339.402.632.63
311.343.643.64
307.402.992.99
345.453.113.11
221.652.322.32
276.344.794.79
334.281.821.82
352.372.452.45
379.463.543.54
315.764.284.28
179.262.692.69
415.863.023.02
413.274.774.77
485.375.465.46
499.395.505.50
499.395.335.33
161.201.921.92
221.264.034.03
227.292.942.94
434.925.095.09
293.331.881.88
312.374.184.18
328.373.673.67
525.614.234.23
423.132.432.43
522.504.844.84
428.442.512.51
640.826.976.97
377.43-0.33-0.33
348.405.085.08
424.912.312.31
458.462.682.68
438.932.452.45
422.403.133.13
438.932.702.70
452.962.842.84
423.923.243.24
442.902.452.45
438.932.702.70
438.932.702.70
438.932.702.70
452.963.093.09
466.993.483.48
430.933.473.47
416.913.083.08
434.903.223.22
451.353.733.73
451.353.733.73
451.353.733.73
465.384.124.12
466.993.483.48
435.353.903.90
414.933.633.63
436.963.003.00
472.593.453.45
309.372.522.52
511.653.813.81
482.634.774.77
254.292.152.15
333.404.704.70
469.575.315.31
490.613.463.46
368.422.382.38
396.473.163.16
423.545.245.24
394.504.494.49
327.412.582.58
365.914.504.50
440.575.185.18
424.534.644.64
424.534.644.64
335.204.054.05
371.814.094.09
321.253.713.71
287.703.343.34
402.393.943.94
372.803.403.40
480.950.870.87
349.433.093.09
311.351.771.77
403.443.073.07
302.834.394.39
300.793.943.94
296.373.303.30
459.572.032.03
333.192.912.91
457.602.932.93
471.623.323.32
471.623.313.31
485.653.713.71
501.653.203.20
306.284.614.61
448.613.303.30
448.613.303.30
498.674.454.45
432.542.582.58
482.603.743.74
447.632.872.87
491.683.273.27
515.623.893.89
482.073.533.53
516.524.184.18
482.073.533.53
466.002.812.81
466.633.023.02
480.950.870.87
462.511.261.26
524.645.315.31
455.485.955.95
455.485.955.95
626.605.695.69
283.363.163.16
355.392.402.40
391.474.154.15
337.382.662.66
434.972.652.65
560.495.355.35
375.454.184.18
293.173.183.18
332.403.503.50
284.343.563.56
419.744.584.58
298.424.124.12
358.474.144.14
376.452.602.60
392.522.352.35
316.291.681.68
426.543.903.90
370.432.342.34
438.554.044.04
452.584.394.39
446.533.913.91
404.543.483.48
427.533.293.29
426.543.903.90
460.994.554.55
427.533.293.29
440.573.963.96
364.472.452.45
479.564.254.25
519.635.125.12
440.574.214.21
412.523.433.43
452.584.354.35
466.614.694.69
452.584.294.29
466.614.604.60
454.553.203.20
440.574.074.07
426.543.823.82
454.604.454.45
454.604.454.45
454.604.454.45
508.575.165.16
539.703.983.98
446.624.424.42
459.553.683.68
483.574.164.16
526.565.305.30
453.522.742.74
466.522.302.30
451.531.831.83
451.531.831.83
349.814.984.98
424.934.214.21
441.434.644.64
422.894.244.24
486.685.265.26
462.664.574.57
476.694.884.88
463.653.963.96
517.766.396.39
518.755.785.78
498.095.275.27
495.665.155.15
491.704.804.80
476.644.184.18
494.634.324.32
477.633.573.57
478.622.972.97
488.655.195.19
500.665.405.40
501.654.794.79
498.610.900.90
637.858.988.98
381.493.413.41
305.442.252.25
425.644.904.90
447.644.784.78
465.634.924.92
391.324.344.34
406.553.803.80
420.584.054.05
406.553.493.49
460.524.034.03
434.614.224.22
448.634.834.83
432.594.194.19
446.624.584.58
460.644.974.97
450.613.673.67
464.634.064.06
478.684.534.53
510.683.213.21
475.663.733.73
543.664.664.66
462.623.823.82
448.593.433.43
488.654.394.39
700.297.807.80
651.085.555.55
569.666.156.15
498.054.154.15
481.593.633.63
481.593.633.63
493.633.503.50
493.633.503.50
516.674.284.28
464.592.892.89
481.593.633.63
477.633.883.88
484.024.104.10
479.603.463.46
493.633.803.80
497.593.473.47
264.283.193.19
503.674.544.54
539.705.685.68
532.494.804.80
454.662.822.82
454.662.872.87
479.562.722.72
609.506.766.76
368.554.424.42
381.883.253.25
417.513.763.76
409.492.812.81
420.903.543.54
316.473.533.53
330.493.923.92
272.291.631.63
453.546.056.05
435.526.946.94
384.662.762.76
472.394.464.46
289.302.392.39
415.454.164.16
410.401.811.81
500.433.733.73
551.463.883.88
505.024.254.25
549.074.004.00
450.012.912.91
432.484.274.27
237.262.382.38
538.653.533.53
443.513.293.29
405.502.202.20
305.302.002.00
373.303.013.01
349.272.842.84
348.292.722.72
323.292.132.13
350.475.915.91
340.434.404.40
339.445.015.01
340.434.404.40
339.445.015.01
343.433.853.85
276.291.291.29
393.393.823.82
203.673.593.59
303.391.941.94
380.473.003.00
500.591.611.61
516.580.850.85
366.845.605.60
434.505.765.76
346.421.451.45
403.471.621.62
411.432.982.98
387.402.312.31
429.483.143.14
382.464.014.01
359.822.992.99
362.454.694.69
387.511.771.77
443.623.073.07
412.521.641.64
438.562.322.32
292.343.413.41
165.171.951.95
147.181.811.81
161.202.122.12
391.433.163.16
326.423.073.07
177.201.821.82
352.393.583.58
385.264.004.00
336.393.253.25
371.234.324.32
396.502.282.28
433.594.974.97
462.495.695.69
501.515.545.54
232.353.843.84
497.641.671.67
469.955.165.16
387.525.705.70
527.485.525.52
448.554.254.25
343.471.481.48
477.593.453.45
477.593.453.45
468.964.934.93
449.504.354.35
401.382.552.55
387.352.162.16
453.862.822.82
348.535.445.44
432.964.994.99
423.903.663.66
561.732.622.62
516.475.125.12
505.495.555.55
505.495.555.55
475.004.734.73
509.455.385.38
489.035.045.04
472.584.524.52
489.035.045.04
523.485.695.69
514.044.914.91
537.506.086.08
503.065.435.43
486.604.914.91
477.435.385.38
477.435.385.38
477.435.385.38
493.435.225.22
493.435.225.22
391.482.432.43
408.483.173.17
451.533.663.66
476.511.801.80
539.682.852.85
577.554.554.55
1065.70
473.560.650.65
459.530.970.97
501.612.102.10
493.981.631.63
540.672.252.25
409.513.643.64
409.513.643.64
462.602.902.90
462.602.902.90
449.563.153.15
474.613.263.26
379.463.433.43
387.514.144.14
411.533.853.85
406.562.672.67
463.323.083.08
483.954.394.39
526.035.415.41
526.035.415.41
584.515.915.91
584.515.915.91
554.096.196.19
554.096.196.19
584.516.066.06
612.566.696.69
568.116.586.58
566.106.346.34
568.075.185.18
415.535.525.52
469.506.156.15
500.525.745.74
381.433.493.49
378.432.992.99
325.372.382.38
609.532.862.86
480.952.692.69
656.626.616.61
428.504.374.37
440.554.894.89
415.433.753.75
580.722.302.30
411.474.634.63
441.524.164.16
420.553.373.37
378.504.994.99
472.604.674.67
478.624.744.74
378.313.783.78
576.103.213.21
576.103.213.21
303.392.192.19
491.953.023.02
505.983.333.33
536.403.133.13
509.943.163.16
441.953.043.04
385.474.524.52
452.564.614.61
453.962.902.90
541.037.257.25
406.522.982.98
405.534.564.56
462.583.623.62
513.614.694.69
463.563.483.48
455.486.656.65
263.302.862.86
740.761.541.54