Basic Information
ID: ALA3301372
Type: ADME
Description: ASTRAZENECA: Intrinsic clearance measured in human hepatocytes following incubation at 37C. Experimental range <3 to >150 microL/min/1E6 cells. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736.
Organism: Homo sapiens
Tissue: Liver
Cell type: Hepatocyte
Activity Charts
Bioactivity
Activity Types for Assay ALA3301372
CL
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 383.41 | 1.78 | 1.78 |
| 232.24 | 1.42 | 1.42 |
| 233.24 | -0.79 | -0.79 |
| 331.35 | 1.58 | 1.58 |
| 280.42 | 3.88 | 3.88 |
| 365.84 | 2.08 | 2.08 |
| 441.55 | 4.37 | 4.37 |
| 284.75 | 3.15 | 3.15 |
| 249.35 | 2.15 | 2.15 |
| 914.19 | 6.18 | 6.18 |
| 454.61 | 5.09 | 5.09 |
| 414.53 | 3.37 | 3.37 |
| 307.43 | 2.39 | 2.39 |
| 330.75 | 1.89 | 1.89 |
| 326.83 | 3.72 | 3.72 |
| 299.76 | 2.95 | 2.95 |
| 315.72 | 3.04 | 3.04 |
| 250.34 | 3.57 | 3.57 |
| 293.37 | 3.13 | 3.13 |
| 385.51 | 2.09 | 2.09 |
| 395.43 | 2.42 | 2.42 |
| 494.01 | 3.64 | 3.64 |
| 441.58 | 1.98 | 1.98 |
| 318.87 | 4.89 | 4.89 |
| 266.39 | 3.53 | 3.53 |
| 248.33 | 1.91 | 1.91 |
| 236.30 | 2.73 | 2.73 |
| 198.27 | 2.70 | 2.70 |
| 309.41 | 3.42 | 3.42 |
| 313.29 | 2.55 | 2.55 |
| 528.68 | 1.77 | 1.77 |
| 393.44 | 3.41 | 3.41 |
| 236.27 | 3.39 | 3.39 |
| 151.16 | 1.35 | 1.35 |
| 286.72 | 2.45 | 2.45 |
| 254.29 | 3.11 | 3.11 |
| 238.16 | 0.07 | 0.07 |
| 321.16 | 3.10 | 3.10 |
| 670.86 | 3.09 | 3.09 |
| 613.80 | 2.87 | 2.87 |
| 381.38 | 3.51 | 3.51 |
| 471.69 | 6.45 | 6.45 |
| 241.68 | 0.82 | 0.82 |
| 291.73 | 2.85 | 2.85 |
| 598.67 | 2.82 | 2.82 |
| 287.36 | 3.38 | 3.38 |
| 188.23 | 1.48 | 1.48 |
| 341.45 | 3.24 | 3.24 |
| 374.48 | 1.80 | 1.80 |
| 325.77 | 4.32 | 4.32 |
| 308.77 | 3.58 | 3.58 |
| 171.16 | 0.09 | 0.09 |
| 355.87 | 5.18 | 5.18 |
| 296.15 | 4.36 | 4.36 |
| 406.48 | 3.74 | 3.74 |
| 435.35 | 4.22 | 4.22 |
| 304.35 | 3.81 | 3.81 |
| 270.35 | 1.78 | 1.78 |
| 586.20 | 8.95 | 8.95 |
| 291.38 | 1.22 | 1.22 |
| 218.21 | 0.88 | 0.88 |
| 231.30 | 1.55 | 1.55 |
| 263.79 | 3.96 | 3.96 |
| 477.05 | 5.09 | 5.09 |
| 261.37 | 3.42 | 3.42 |
| 470.61 | 6.33 | 6.33 |
| 320.34 | 2.73 | 2.73 |
| 239.75 | 3.30 | 3.30 |
| 250.20 | 3.04 | 3.04 |
| 162.14 | 1.50 | 1.50 |
| 515.62 | 4.93 | 4.93 |
| 229.63 | -1.08 | -1.08 |
| 481.34 | 4.76 | 4.76 |
| 260.31 | 3.17 | 3.17 |
| 216.28 | 1.77 | 1.77 |
| 551.63 | 4.20 | 4.20 |
| 270.21 | 3.25 | 3.25 |
| 312.41 | 2.53 | 2.53 |
| 514.63 | 7.26 | 7.26 |
| 257.29 | 2.19 | 2.19 |
| 360.41 | 2.36 | 2.36 |
| 388.56 | 5.81 | 5.81 |
| 464.61 | 2.90 | 2.90 |
| 196.25 | 2.42 | 2.42 |
| 370.92 | 4.79 | 4.79 |
| 293.32 | 4.03 | 4.03 |
| 445.55 | 2.08 | 2.08 |
| 197.23 | 0.70 | 0.70 |
| 365.41 | 0.02 | 0.02 |
| 168.20 | 2.02 | 2.02 |
| 527.67 | 5.99 | 5.99 |
| 424.53 | 2.44 | 2.44 |
| 610.58 | 2.32 | 2.32 |
| 244.30 | 0.25 | 0.25 |
| 589.18 | 4.56 | 4.56 |
| 344.21 | 4.18 | 4.18 |
| 30.07 | 1.03 | 1.03 |
| 282.34 | 2.39 | 2.39 |
| 523.55 | 1.09 | 1.09 |
| 452.60 | 5.22 | 5.22 |
| 324.42 | 3.17 | 3.17 |
| 175.24 | 0.94 | 0.94 |
| 316.43 | 0.50 | 0.50 |
| 426.56 | 3.96 | 3.96 |
| 510.64 | 7.46 | 7.46 |
| 416.47 | 3.09 | 3.09 |
| 469.89 | 3.38 | 3.38 |
| 469.89 | 3.38 | 3.38 |
| 332.34 | 1.30 | 1.30 |
| 344.41 | 2.22 | 2.22 |
| 169.57 | 1.77 | 1.77 |
| 190.20 | 2.19 | 2.19 |
| 411.46 | 6.06 | 6.06 |
| 425.46 | 2.36 | 2.36 |
| 325.17 | 4.92 | 4.92 |
| 397.48 | 3.42 | 3.42 |
| 397.48 | 3.42 | 3.42 |
| 374.44 | 4.25 | 4.25 |
| 392.43 | 4.39 | 4.39 |
| 331.38 | 3.88 | 3.88 |
| 288.43 | 3.88 | 3.88 |
| 339.47 | 4.10 | 4.10 |
| 285.31 | 2.66 | 2.66 |
| 315.68 | 4.07 | 4.07 |
| 180.17 | -1.04 | -1.04 |
| 400.28 | 5.28 | 5.28 |
| 346.31 | 4.56 | 4.56 |
| 389.48 | 4.16 | 4.16 |
| 364.39 | 4.60 | 4.60 |
| 380.39 | 4.27 | 4.27 |
| 360.34 | 4.49 | 4.49 |
| 308.33 | 3.61 | 3.61 |
| 413.48 | 2.39 | 2.39 |
| 383.45 | 3.03 | 3.03 |
| 365.46 | 2.89 | 2.89 |
| 396.71 | 4.51 | 4.51 |
| 401.98 | 3.69 | 3.69 |
| 500.58 | 4.43 | 4.43 |
| 459.56 | 4.88 | 4.88 |
| 490.63 | 3.07 | 3.07 |
| 265.34 | 3.24 | 3.24 |
| 479.53 | 3.68 | 3.68 |
| 474.59 | 1.61 | 1.61 |
| 360.45 | 1.99 | 1.99 |
| 346.34 | 2.18 | 2.18 |
| 428.54 | 4.78 | 4.78 |
| 371.39 | 2.58 | 2.58 |
| 308.33 | 3.61 | 3.61 |
| 308.33 | 3.61 | 3.61 |
| 349.52 | 5.40 | 5.40 |
| 428.49 | 3.09 | 3.09 |
| 437.50 | 0.90 | 0.90 |
| 351.38 | 2.72 | 2.72 |
| 379.39 | 2.08 | 2.08 |
| 369.50 | 2.23 | 2.23 |
| 338.41 | 2.06 | 2.06 |
| 348.45 | 2.46 | 2.46 |
| 366.44 | 2.60 | 2.60 |
| 400.89 | 3.26 | 3.26 |
| 492.66 | 3.77 | 3.77 |
| 217.29 | 0.63 | 0.63 |
| 375.56 | 4.57 | 4.57 |
| 488.57 | 4.44 | 4.44 |
| 392.46 | 2.50 | 2.50 |
| 645.68 | -1.11 | -1.11 |
| 468.95 | 3.82 | 3.82 |
| 348.38 | 4.31 | 4.31 |
| 392.84 | 1.39 | 1.39 |
| 424.81 | 3.85 | 3.85 |
| 501.51 | 4.10 | 4.10 |
| 367.49 | 3.83 | 3.83 |
| 414.89 | 2.52 | 2.52 |
| 500.36 | 5.43 | 5.43 |
| 419.50 | 2.19 | 2.19 |
| 419.50 | 2.19 | 2.19 |
| 194.26 | 2.28 | 2.28 |
| 518.60 | 3.93 | 3.93 |
| 581.47 | 5.75 | 5.75 |
| 364.39 | 3.40 | 3.40 |
| 294.81 | 4.17 | 4.17 |
| 176.18 | 1.57 | 1.57 |
| 241.25 | 2.69 | 2.69 |
| 274.41 | 3.51 | 3.51 |
| 477.31 | 4.43 | 4.43 |
| 383.47 | 3.86 | 3.86 |
| 387.40 | 0.49 | 0.49 |
| 371.40 | 1.56 | 1.56 |
| 470.60 | 4.78 | 4.78 |
| 370.45 | 5.86 | 5.86 |
| 487.64 | 6.35 | 6.35 |
| 316.38 | 3.72 | 3.72 |
| 532.57 | 4.46 | 4.46 |
| 484.66 | 4.67 | 4.67 |
| 254.29 | -0.19 | -0.19 |
| 421.47 | 4.52 | 4.52 |
| 415.86 | 3.22 | 3.22 |
| 397.44 | 2.77 | 2.77 |
| 507.53 | 4.28 | 4.28 |
| 522.64 | 3.62 | 3.62 |
| 409.53 | 3.12 | 3.12 |
| 489.93 | 5.54 | 5.54 |
| 494.98 | 4.55 | 4.55 |
| 374.47 | 4.36 | 4.36 |
| 423.90 | 3.66 | 3.66 |
| 425.49 | 2.25 | 2.25 |
| 518.49 | -1.41 | -1.41 |
| 455.52 | 4.62 | 4.62 |
| 429.60 | 5.41 | 5.41 |
| 312.39 | 3.73 | 3.73 |
| 454.94 | 3.73 | 3.73 |
| 297.34 | 2.46 | 2.46 |
| 255.36 | 3.95 | 3.95 |
| 346.84 | 4.27 | 4.27 |
| 249.32 | 3.43 | 3.43 |
| 254.31 | 3.55 | 3.55 |
| 340.46 | 4.37 | 4.37 |
| 259.29 | 2.05 | 2.05 |
| 281.75 | 4.05 | 4.05 |
| 345.45 | 3.11 | 3.11 |
| 382.27 | 4.33 | 4.33 |
| 415.86 | 3.02 | 3.02 |
| 267.25 | 3.86 | 3.86 |
| 322.22 | 4.76 | 4.76 |
| 220.29 | 2.98 | 2.98 |
| 361.42 | 3.04 | 3.04 |
| 519.60 | 3.36 | 3.36 |
| 549.62 | 2.98 | 2.98 |
| 479.53 | 2.58 | 2.58 |
| 465.51 | 2.27 | 2.27 |
| 493.56 | 2.97 | 2.97 |
| 507.59 | 3.35 | 3.35 |
| 521.61 | 3.60 | 3.60 |
| 505.57 | 3.13 | 3.13 |
| 522.56 | 1.43 | 1.43 |
| 523.59 | 2.59 | 2.59 |
| 562.67 | 3.04 | 3.04 |
| 377.43 | -0.33 | -0.33 |
| 348.40 | 5.08 | 5.08 |
| 424.91 | 2.31 | 2.31 |
| 458.46 | 2.68 | 2.68 |
| 438.93 | 2.45 | 2.45 |
| 442.90 | 2.45 | 2.45 |
| 438.93 | 2.70 | 2.70 |
| 416.91 | 3.08 | 3.08 |
| 434.90 | 3.22 | 3.22 |
| 451.35 | 3.73 | 3.73 |
| 465.38 | 4.12 | 4.12 |
| 435.35 | 3.90 | 3.90 |
| 436.96 | 3.00 | 3.00 |
| 309.37 | 2.52 | 2.52 |
| 469.57 | 5.31 | 5.31 |
| 571.78 | 4.23 | 4.23 |
| 335.20 | 4.05 | 4.05 |
| 321.25 | 3.71 | 3.71 |
| 402.39 | 3.94 | 3.94 |
| 372.80 | 3.40 | 3.40 |
| 480.95 | 0.87 | 0.87 |
| 360.42 | 3.40 | 3.40 |
| 314.41 | 1.46 | 1.46 |
| 333.19 | 2.91 | 2.91 |
| 268.32 | 2.46 | 2.46 |
| 485.65 | 3.71 | 3.71 |
| 498.67 | 4.45 | 4.45 |
| 432.54 | 2.58 | 2.58 |
| 447.63 | 2.87 | 2.87 |
| 482.07 | 3.53 | 3.53 |
| 516.52 | 4.18 | 4.18 |
| 476.97 | 4.92 | 4.92 |
| 425.88 | 3.27 | 3.27 |
| 477.96 | 3.37 | 3.37 |
| 493.96 | 2.84 | 2.84 |
| 507.98 | 3.23 | 3.23 |
| 480.95 | 0.87 | 0.87 |
| 438.45 | 6.53 | 6.53 |
| 524.64 | 5.31 | 5.31 |
| 455.48 | 5.95 | 5.95 |
| 391.47 | 4.15 | 4.15 |
| 337.38 | 2.66 | 2.66 |
| 434.97 | 2.65 | 2.65 |
| 560.49 | 5.35 | 5.35 |
| 419.74 | 4.58 | 4.58 |
| 392.52 | 2.35 | 2.35 |
| 519.63 | 5.12 | 5.12 |
| 440.57 | 4.21 | 4.21 |
| 454.60 | 4.45 | 4.45 |
| 483.57 | 4.16 | 4.16 |
| 526.56 | 5.30 | 5.30 |
| 424.93 | 4.21 | 4.21 |
| 389.50 | 3.90 | 3.90 |
| 456.93 | 2.89 | 2.89 |
| 408.86 | 3.85 | 3.85 |
| 441.43 | 4.64 | 4.64 |
| 422.89 | 4.24 | 4.24 |
| 391.32 | 4.34 | 4.34 |
| 420.58 | 4.05 | 4.05 |
| 488.65 | 4.39 | 4.39 |
| 381.86 | 4.26 | 4.26 |
| 700.29 | 7.80 | 7.80 |
| 651.08 | 5.55 | 5.55 |
| 435.52 | 2.97 | 2.97 |
| 481.59 | 3.63 | 3.63 |
| 464.59 | 2.89 | 2.89 |
| 464.59 | 2.89 | 2.89 |
| 532.49 | 4.80 | 4.80 |
| 430.47 | 5.81 | 5.81 |
| 609.50 | 6.76 | 6.76 |
| 457.00 | 5.53 | 5.53 |
| 379.25 | 2.69 | 2.69 |
| 538.66 | 2.60 | 2.60 |
| 244.29 | 3.33 | 3.33 |
| 226.30 | 3.19 | 3.19 |
| 407.46 | 3.32 | 3.32 |
| 415.45 | 4.16 | 4.16 |
| 409.92 | 4.68 | 4.68 |
| 410.40 | 1.81 | 1.81 |
| 505.02 | 4.25 | 4.25 |
| 549.07 | 4.00 | 4.00 |
| 350.47 | 5.91 | 5.91 |
| 340.43 | 4.40 | 4.40 |
| 339.44 | 5.01 | 5.01 |
| 382.47 | 4.11 | 4.11 |
| 339.44 | 5.01 | 5.01 |
| 340.43 | 4.40 | 4.40 |
| 351.45 | 5.30 | 5.30 |
| 351.45 | 5.30 | 5.30 |
| 339.44 | 5.01 | 5.01 |
| 339.44 | 5.01 | 5.01 |
| 340.43 | 4.40 | 4.40 |
| 353.47 | 5.25 | 5.25 |
| 343.43 | 3.85 | 3.85 |
| 276.29 | 1.29 | 1.29 |
| 500.59 | 1.61 | 1.61 |
| 516.58 | 0.85 | 0.85 |
| 366.84 | 5.60 | 5.60 |
| 244.13 | 2.75 | 2.75 |
| 382.46 | 4.01 | 4.01 |
| 515.66 | 2.33 | 2.33 |
| 438.56 | 2.32 | 2.32 |
| 438.56 | 2.32 | 2.32 |
| 443.57 | 1.84 | 1.84 |
| 165.17 | 1.95 | 1.95 |
| 147.18 | 1.81 | 1.81 |
| 161.20 | 2.12 | 2.12 |
| 391.43 | 3.16 | 3.16 |
| 326.42 | 3.07 | 3.07 |
| 399.29 | 3.35 | 3.35 |
| 388.39 | 3.61 | 3.61 |
| 236.28 | 2.84 | 2.84 |
| 223.23 | 2.92 | 2.92 |
| 300.38 | 2.92 | 2.92 |
| 177.20 | 1.82 | 1.82 |
| 394.43 | 2.47 | 2.47 |
| 501.51 | 5.54 | 5.54 |
| 546.72 | 2.72 | 2.72 |
| 469.95 | 5.16 | 5.16 |
| 349.47 | 2.64 | 2.64 |
| 231.28 | 2.57 | 2.57 |
| 527.48 | 5.52 | 5.52 |
| 343.47 | 1.48 | 1.48 |
| 477.59 | 3.45 | 3.45 |
| 477.59 | 3.45 | 3.45 |
| 468.96 | 4.93 | 4.93 |
| 548.94 | 5.04 | 5.04 |
| 369.51 | 3.84 | 3.84 |
| 395.51 | 5.24 | 5.24 |
| 458.42 | 5.08 | 5.08 |
| 448.83 | 5.80 | 5.80 |
| 516.47 | 5.12 | 5.12 |
| 514.04 | 4.91 | 4.91 |
| 503.06 | 5.43 | 5.43 |
| 486.60 | 4.91 | 4.91 |
| 477.43 | 5.38 | 5.38 |
| 509.45 | 5.38 | 5.38 |
| 454.40 | 4.44 | 4.44 |
| 462.60 | 2.90 | 2.90 |
| 462.60 | 2.90 | 2.90 |
| 449.56 | 3.15 | 3.15 |
| 474.61 | 3.26 | 3.26 |
| 454.57 | 2.72 | 2.72 |
| 424.49 | 2.16 | 2.16 |
| 458.01 | 3.10 | 3.10 |
| 463.32 | 3.08 | 3.08 |
| 500.52 | 5.74 | 5.74 |
| 381.43 | 3.49 | 3.49 |
| 378.43 | 2.99 | 2.99 |
| 480.95 | 2.69 | 2.69 |
| 440.55 | 4.89 | 4.89 |
| 415.43 | 3.75 | 3.75 |
| 427.33 | 3.89 | 3.89 |
| 500.36 | 5.15 | 5.15 |
| 399.48 | 1.89 | 1.89 |
| 576.10 | 3.21 | 3.21 |
| 576.10 | 3.21 | 3.21 |
| 398.96 | 3.50 | 3.50 |
| 479.58 | 3.20 | 3.20 |
| 506.61 | 2.85 | 2.85 |
| 473.54 | 2.38 | 2.38 |
| 492.58 | 1.86 | 1.86 |
| 387.31 | 2.51 | 2.51 |
| 459.42 | 2.90 | 2.90 |
| 419.61 | 1.79 | 1.79 |
| 421.57 | 4.48 | 4.48 |
| 415.54 | 3.68 | 3.68 |
| 390.53 | 3.49 | 3.49 |
| 362.48 | 2.85 | 2.85 |
| 389.55 | 3.78 | 3.78 |
| 455.48 | 6.65 | 6.65 |
| 740.76 | 1.54 | 1.54 |