Basic Information
ID: ALA3301375
Type: Physicochemical
Description: ASTRAZENECA: Most acidic pKa value (pKa A1) determined by absorption and potentiometric titration using standard methodology from Sirius Analytical. Experimental range Acids: <= 11.
Activity Charts
Bioactivity
Activity Types for Assay ALA3301375
pKa_A1
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 361.37 | 1.54 | 1.54 |
| 399.40 | 2.72 | 2.72 |
| 369.34 | 1.70 | 1.70 |
| 331.35 | 1.58 | 1.58 |
| 272.39 | 3.61 | 3.61 |
| 334.40 | 0.86 | 0.86 |
| 375.40 | 1.98 | 1.98 |
| 401.44 | 2.37 | 2.37 |
| 389.39 | 0.97 | 0.97 |
| 330.75 | 1.89 | 1.89 |
| 255.32 | 1.53 | 1.53 |
| 250.28 | 0.86 | 0.86 |
| 214.25 | 0.09 | 0.09 |
| 494.01 | 3.64 | 3.64 |
| 441.58 | 1.98 | 1.98 |
| 273.19 | -0.44 | -0.44 |
| 257.32 | 2.27 | 2.27 |
| 351.41 | 1.56 | 1.56 |
| 468.37 | 2.11 | 2.11 |
| 276.75 | 1.74 | 1.74 |
| 308.34 | 2.52 | 2.52 |
| 247.38 | 3.37 | 3.37 |
| 292.34 | 2.86 | 2.86 |
| 333.36 | 1.61 | 1.61 |
| 365.79 | 2.36 | 2.36 |
| 351.35 | 1.80 | 1.80 |
| 151.16 | 1.35 | 1.35 |
| 356.42 | 4.37 | 4.37 |
| 254.29 | 3.11 | 3.11 |
| 376.45 | 1.60 | 1.60 |
| 276.38 | 2.55 | 2.55 |
| 287.36 | 3.38 | 3.38 |
| 281.23 | 4.15 | 4.15 |
| 296.15 | 4.36 | 4.36 |
| 179.22 | 0.91 | 0.91 |
| 148.16 | 1.78 | 1.78 |
| 371.35 | 2.48 | 2.48 |
| 165.19 | 0.70 | 0.70 |
| 167.21 | 0.86 | 0.86 |
| 270.35 | 1.78 | 1.78 |
| 586.20 | 8.95 | 8.95 |
| 187.20 | 1.43 | 1.43 |
| 357.17 | 3.24 | 3.24 |
| 311.41 | 1.77 | 1.77 |
| 320.32 | 0.66 | 0.66 |
| 404.49 | 3.80 | 3.80 |
| 171.17 | 0.74 | 0.74 |
| 392.41 | 2.08 | 2.08 |
| 320.34 | 2.73 | 2.73 |
| 285.37 | 2.20 | 2.20 |
| 162.14 | 1.50 | 1.50 |
| 189.17 | 1.23 | 1.23 |
| 204.23 | 1.15 | 1.15 |
| 501.67 | 5.51 | 5.51 |
| 221.65 | 2.08 | 2.08 |
| 157.21 | 0.84 | 0.84 |
| 388.90 | 3.15 | 3.15 |
| 153.14 | 0.51 | 0.51 |
| 201.23 | 1.74 | 1.74 |
| 338.77 | 0.92 | 0.92 |
| 190.15 | 1.49 | 1.49 |
| 190.15 | 1.49 | 1.49 |
| 435.53 | 4.16 | 4.16 |
| 293.32 | 4.03 | 4.03 |
| 364.42 | 3.04 | 3.04 |
| 445.55 | 2.08 | 2.08 |
| 365.41 | 0.02 | 0.02 |
| 313.42 | 1.13 | 1.13 |
| 181.16 | -1.64 | -1.64 |
| 462.51 | -0.23 | -0.23 |
| 270.34 | 1.23 | 1.23 |
| 262.22 | 0.84 | 0.84 |
| 234.30 | 0.63 | 0.63 |
| 188.22 | 1.89 | 1.89 |
| 207.27 | 1.52 | 1.52 |
| 525.64 | -0.65 | -0.65 |
| 179.22 | 0.91 | 0.91 |
| 206.15 | 1.20 | 1.20 |
| 278.40 | 3.02 | 3.02 |
| 426.56 | 3.96 | 3.96 |
| 349.41 | 0.32 | 0.32 |
| 556.77 | 7.05 | 7.05 |
| 283.39 | 2.06 | 2.06 |
| 375.35 | 1.09 | 1.09 |
| 216.24 | 0.89 | 0.89 |
| 411.46 | 6.06 | 6.06 |
| 290.37 | 2.67 | 2.67 |
| 314.35 | 1.22 | 1.22 |
| 315.33 | 0.78 | 0.78 |
| 364.83 | 5.21 | 5.21 |
| 364.83 | 5.21 | 5.21 |
| 398.38 | 5.58 | 5.58 |
| 230.68 | 1.68 | 1.68 |
| 225.21 | -1.33 | -1.33 |
| 453.88 | 2.69 | 2.69 |
| 180.17 | -1.04 | -1.04 |
| 433.50 | 2.52 | 2.52 |
| 265.34 | 3.24 | 3.24 |
| 352.14 | 3.71 | 3.71 |
| 428.54 | 4.78 | 4.78 |
| 170.24 | 1.38 | 1.38 |
| 444.42 | 0.91 | 0.91 |
| 399.45 | 3.24 | 3.24 |
| 428.49 | 3.09 | 3.09 |
| 400.44 | 2.49 | 2.49 |
| 461.50 | 0.09 | 0.09 |
| 253.26 | -0.90 | -0.90 |
| 172.19 | 1.37 | 1.37 |
| 331.40 | 1.73 | 1.73 |
| 437.43 | 1.86 | 1.86 |
| 403.41 | 2.55 | 2.55 |
| 378.40 | 2.68 | 2.68 |
| 379.39 | 2.08 | 2.08 |
| 461.54 | 2.82 | 2.82 |
| 348.45 | 2.46 | 2.46 |
| 217.29 | 0.63 | 0.63 |
| 405.24 | 2.20 | 2.20 |
| 423.94 | 5.65 | 5.65 |
| 212.21 | 1.30 | 1.30 |
| 414.89 | 2.52 | 2.52 |
| 298.78 | 3.07 | 3.07 |
| 479.40 | 5.54 | 5.54 |
| 370.45 | 5.86 | 5.86 |
| 558.60 | 4.17 | 4.17 |
| 519.57 | -0.71 | -0.71 |
| 471.55 | -0.73 | -0.73 |
| 415.86 | 3.22 | 3.22 |
| 361.74 | 3.34 | 3.34 |
| 317.73 | 3.65 | 3.65 |
| 356.33 | 2.73 | 2.73 |
| 175.19 | 1.43 | 1.43 |
| 244.29 | 2.72 | 2.72 |
| 346.84 | 4.27 | 4.27 |
| 224.60 | 2.14 | 2.14 |
| 214.27 | 2.71 | 2.71 |
| 264.33 | 3.86 | 3.86 |
| 220.18 | 1.50 | 1.50 |
| 455.47 | -0.62 | -0.62 |
| 485.37 | 5.46 | 5.46 |
| 499.39 | 5.33 | 5.33 |
| 424.91 | 2.31 | 2.31 |
| 422.40 | 3.13 | 3.13 |
| 452.96 | 2.84 | 2.84 |
| 423.92 | 3.24 | 3.24 |
| 416.91 | 3.08 | 3.08 |
| 149.15 | 1.18 | 1.18 |
| 273.24 | 2.73 | 2.73 |
| 243.26 | 2.40 | 2.40 |
| 422.81 | 4.28 | 4.28 |
| 402.39 | 3.94 | 3.94 |
| 372.80 | 3.40 | 3.40 |
| 389.26 | 3.92 | 3.92 |
| 430.44 | 4.72 | 4.72 |
| 430.44 | 4.72 | 4.72 |
| 400.42 | 4.49 | 4.49 |
| 217.18 | 0.05 | 0.05 |
| 216.16 | 2.72 | 2.72 |
| 452.58 | 4.39 | 4.39 |
| 404.54 | 3.48 | 3.48 |
| 427.53 | 3.29 | 3.29 |
| 426.54 | 3.90 | 3.90 |
| 440.57 | 4.21 | 4.21 |
| 508.57 | 5.16 | 5.16 |
| 483.57 | 4.16 | 4.16 |
| 526.56 | 5.30 | 5.30 |
| 345.85 | 5.15 | 5.15 |
| 424.93 | 4.21 | 4.21 |
| 377.85 | 3.83 | 3.83 |
| 456.93 | 2.89 | 2.89 |
| 406.55 | 3.80 | 3.80 |
| 420.58 | 4.05 | 4.05 |
| 434.61 | 4.22 | 4.22 |
| 448.63 | 4.83 | 4.83 |
| 488.65 | 4.39 | 4.39 |
| 700.29 | 7.80 | 7.80 |
| 374.66 | 3.31 | 3.31 |
| 384.66 | 2.76 | 2.76 |
| 551.46 | 3.88 | 3.88 |
| 401.37 | 3.18 | 3.18 |
| 286.33 | 3.32 | 3.32 |
| 343.41 | 2.67 | 2.67 |
| 527.48 | 5.52 | 5.52 |
| 172.57 | 1.74 | 1.74 |
| 516.47 | 5.12 | 5.12 |
| 505.49 | 5.55 | 5.55 |
| 463.41 | 5.13 | 5.13 |
| 477.43 | 5.37 | 5.37 |
| 463.41 | 5.45 | 5.45 |
| 463.41 | 5.45 | 5.45 |
| 463.41 | 5.45 | 5.45 |
| 477.43 | 5.38 | 5.38 |
| 493.43 | 5.22 | 5.22 |
| 477.43 | 5.45 | 5.45 |
| 477.43 | 5.45 | 5.45 |
| 477.43 | 5.45 | 5.45 |
| 491.46 | 5.24 | 5.24 |
| 491.46 | 5.24 | 5.24 |
| 512.46 | 3.98 | 3.98 |
| 507.41 | 4.60 | 4.60 |
| 477.39 | 4.84 | 4.84 |
| 501.42 | 4.32 | 4.32 |
| 512.46 | 4.40 | 4.40 |
| 530.45 | 4.54 | 4.54 |
| 546.90 | 5.05 | 5.05 |
| 542.49 | 4.41 | 4.41 |
| 555.53 | 4.47 | 4.47 |
| 526.49 | 4.71 | 4.71 |
| 555.53 | 4.47 | 4.47 |
| 540.51 | 5.02 | 5.02 |
| 463.32 | 3.08 | 3.08 |
| 481.30 | 3.37 | 3.37 |
| 508.32 | 3.33 | 3.33 |
| 487.91 | 2.99 | 2.99 |
| 490.39 | 3.47 | 3.47 |
| 484.41 | 3.05 | 3.05 |
| 359.43 | 5.04 | 5.04 |
| 500.36 | 5.15 | 5.15 |
| 545.93 | 5.59 | 5.59 |
| 524.96 | 4.07 | 4.07 |
| 315.37 | 2.50 | 2.50 |
| 740.76 | 1.54 | 1.54 |