Basic Information
ID: ALA3301548
Type: Functional
Description: MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth.
Organism: Saccharomyces cerevisiae
Activity Charts
Bioactivity
Activity Types for Assay ALA3301548
Relative Growth
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 350.03 | 5.94 | 5.94 |
| 291.40 | 3.88 | 3.88 |
| 367.49 | 3.73 | 3.73 |
| 243.22 | -2.56 | -2.56 |
| 277.80 | 3.64 | 3.64 |
| 368.48 | 4.88 | 4.88 |
| 279.39 | 3.75 | 3.75 |
| 288.31 | 3.36 | 3.36 |
| 337.18 | 4.12 | 4.12 |
| 348.41 | 2.03 | 2.03 |
| 245.28 | 2.68 | 2.68 |
| 272.31 | 3.66 | 3.66 |
| 440.46 | 5.39 | 5.39 |
| 325.59 | 4.75 | 4.75 |
| 267.36 | 4.26 | 4.26 |
| 319.45 | 4.59 | 4.59 |
| 275.31 | 3.33 | 3.33 |
| 273.33 | 2.44 | 2.44 |
| 346.40 | 3.33 | 3.33 |
| 270.33 | 4.90 | 4.90 |
| 339.35 | 3.31 | 3.31 |
| 302.76 | 2.96 | 2.96 |
| 361.23 | 4.16 | 4.16 |
| 297.79 | 1.27 | 1.27 |
| 290.25 | 3.79 | 3.79 |
| 441.86 | 4.82 | 4.82 |
| 405.50 | 4.80 | 4.80 |
| 338.28 | 4.62 | 4.62 |
| 359.41 | 1.47 | 1.47 |
| 347.26 | 3.78 | 3.78 |
| 332.36 | 4.70 | 4.70 |
| 298.77 | 4.95 | 4.95 |
| 444.60 | 4.99 | 4.99 |
| 403.44 | 4.51 | 4.51 |
| 278.31 | 3.90 | 3.90 |
| 420.51 | 6.71 | 6.71 |
| 368.66 | 4.80 | 4.80 |
| 323.35 | 3.09 | 3.09 |
| 367.28 | 3.70 | 3.70 |
| 249.75 | 2.91 | 2.91 |
| 442.32 | 6.40 | 6.40 |
| 510.43 | 7.68 | 7.68 |
| 571.68 | 7.18 | 7.18 |
| 383.67 | 4.94 | 4.94 |
| 393.40 | 4.51 | 4.51 |
| 476.05 | 7.29 | 7.29 |
| 448.37 | 7.15 | 7.15 |
| 372.42 | 5.13 | 5.13 |
| 465.59 | 3.98 | 3.98 |
| 431.56 | 6.92 | 6.92 |
| 367.41 | 2.53 | 2.53 |
| 456.98 | 5.34 | 5.34 |
| 412.49 | 5.47 | 5.47 |
| 479.85 | 3.90 | 3.90 |
| 398.51 | 5.20 | 5.20 |
| 497.75 | 4.59 | 4.59 |
| 354.47 | 4.02 | 4.02 |
| 440.53 | 3.52 | 3.52 |
| 413.53 | 4.11 | 4.11 |
| 307.86 | 3.70 | 3.70 |
| 420.68 | 5.55 | 5.55 |
| 359.77 | 3.66 | 3.66 |
| 420.49 | 3.68 | 3.68 |
| 484.96 | 3.17 | 3.17 |
| 500.58 | 3.67 | 3.67 |
| 397.50 | 4.24 | 4.24 |
| 341.44 | 5.94 | 5.94 |
| 574.24 | 5.29 | 5.29 |
| 384.50 | 4.03 | 4.03 |
| 346.43 | 4.20 | 4.20 |
| 346.82 | 2.79 | 2.79 |
| 436.58 | 5.22 | 5.22 |
| 418.59 | 4.27 | 4.27 |
| 261.41 | 4.11 | 4.11 |
| 385.87 | 5.30 | 5.30 |
| 456.51 | 4.03 | 4.03 |
| 377.87 | 4.09 | 4.09 |
| 328.17 | 4.12 | 4.12 |
| 493.61 | 4.00 | 4.00 |
| 381.82 | 4.25 | 4.25 |
| 319.36 | 3.47 | 3.47 |
| 391.49 | 4.52 | 4.52 |
| 343.39 | 4.49 | 4.49 |
| 309.82 | 3.80 | 3.80 |
| 252.32 | 2.88 | 2.88 |
| 636.71 | 10.45 | 10.45 |
| 491.54 | 4.32 | 4.32 |
| 413.52 | 5.59 | 5.59 |
| 397.54 | 3.75 | 3.75 |
| 354.41 | 4.46 | 4.46 |
| 189.22 | 1.53 | 1.53 |
| 312.42 | 4.34 | 4.34 |
| 438.90 | 4.04 | 4.04 |
| 326.45 | 4.46 | 4.46 |
| 292.34 | 3.42 | 3.42 |
| 362.44 | 4.24 | 4.24 |
| 281.28 | 2.92 | 2.92 |
| 420.18 | 4.45 | 4.45 |
| 403.92 | 4.79 | 4.79 |
| 307.38 | 2.49 | 2.49 |
| 487.77 | 6.43 | 6.43 |
| 389.80 | 3.67 | 3.67 |
| 507.05 | 4.87 | 4.87 |
| 441.33 | 4.79 | 4.79 |
| 430.52 | 5.53 | 5.53 |
| 400.95 | 4.57 | 4.57 |
| 218.26 | 1.35 | 1.35 |
| 286.77 | 3.26 | 3.26 |
| 462.43 | 3.68 | 3.68 |
| 495.07 | 4.07 | 4.07 |
| 432.36 | 3.28 | 3.28 |
| 459.93 | 6.39 | 6.39 |
| 456.98 | 5.34 | 5.34 |
| 480.01 | 5.37 | 5.37 |
| 349.53 | 4.70 | 4.70 |
| 366.35 | 5.45 | 5.45 |
| 309.32 | 3.38 | 3.38 |
| 422.44 | 5.33 | 5.33 |
| 322.45 | 4.08 | 4.08 |
| 341.72 | 4.16 | 4.16 |
| 726.97 | 5.87 | 5.87 |
| 494.56 | 3.01 | 3.01 |
| 370.49 | 3.80 | 3.80 |
| 303.39 | 3.91 | 3.91 |
| 496.01 | 7.33 | 7.33 |
| 447.54 | 6.42 | 6.42 |
| 434.54 | 3.95 | 3.95 |
| 494.66 | 4.96 | 4.96 |
| 329.38 | 2.38 | 2.38 |
| 340.40 | 3.76 | 3.76 |
| 431.32 | 5.34 | 5.34 |
| 459.62 | 4.69 | 4.69 |
| 340.79 | 4.72 | 4.72 |
| 357.41 | 4.88 | 4.88 |
| 364.45 | 5.25 | 5.25 |
| 493.40 | 4.64 | 4.64 |
| 448.52 | 4.30 | 4.30 |
| 377.87 | 4.64 | 4.64 |
| 515.15 | 7.63 | 7.63 |
| 388.52 | 4.85 | 4.85 |
| 458.63 | 5.30 | 5.30 |
| 373.41 | 4.50 | 4.50 |
| 457.83 | 4.30 | 4.30 |
| 327.70 | 3.85 | 3.85 |
| 479.54 | 3.31 | 3.31 |
| 367.53 | 5.10 | 5.10 |
| 470.17 | 6.64 | 6.64 |
| 422.32 | 4.75 | 4.75 |
| 426.54 | 4.88 | 4.88 |
| 347.84 | 4.63 | 4.63 |
| 445.53 | 5.14 | 5.14 |
| 268.32 | 3.00 | 3.00 |
| 586.75 | 5.63 | 5.63 |
| 465.62 | 7.40 | 7.40 |
| 280.17 | 3.96 | 3.96 |
| 353.38 | 1.40 | 1.40 |
| 393.49 | 2.91 | 2.91 |
| 356.43 | 4.99 | 4.99 |
| 405.50 | 3.62 | 3.62 |
| 387.49 | 6.34 | 6.34 |
| 496.50 | 5.20 | 5.20 |
| 228.34 | 3.17 | 3.17 |
| 434.49 | 5.47 | 5.47 |
| 283.71 | 4.01 | 4.01 |
| 371.87 | 2.83 | 2.83 |
| 199.25 | 2.41 | 2.41 |
| 298.77 | 5.03 | 5.03 |
| 378.49 | 4.12 | 4.12 |
| 453.33 | 5.78 | 5.78 |
| 468.34 | 3.78 | 3.78 |
| 199.25 | 2.98 | 2.98 |
| 423.43 | 3.39 | 3.39 |
| 274.39 | 3.85 | 3.85 |
| 267.34 | 3.05 | 3.05 |
| 265.32 | 2.98 | 2.98 |
| 260.35 | 0.94 | 0.94 |
| 460.54 | 6.38 | 6.38 |
| 326.40 | 4.99 | 4.99 |
| 316.79 | 4.00 | 4.00 |
| 332.51 | 4.23 | 4.23 |
| 427.32 | 2.76 | 2.76 |
| 422.96 | 3.07 | 3.07 |
| 384.31 | 3.95 | 3.95 |
| 380.44 | 4.79 | 4.79 |
| 341.42 | 4.76 | 4.76 |
| 319.43 | 3.52 | 3.52 |
| 554.51 | 7.90 | 7.90 |
| 328.20 | 2.53 | 2.53 |
| 268.14 | 4.11 | 4.11 |
| 445.52 | 3.51 | 3.51 |
| 274.32 | 3.41 | 3.41 |
| 362.43 | 3.88 | 3.88 |
| 419.48 | 6.33 | 6.33 |
| 659.69 | 6.64 | 6.64 |
| 293.32 | 3.78 | 3.78 |
| 345.83 | 2.90 | 2.90 |
| 413.59 | 6.79 | 6.79 |
| 337.43 | 5.52 | 5.52 |
| 359.43 | 5.61 | 5.61 |
| 201.27 | 3.20 | 3.20 |
| 334.38 | 3.52 | 3.52 |
| 357.41 | 2.07 | 2.07 |
| 496.69 | 5.56 | 5.56 |
| 645.20 | 6.86 | 6.86 |
| 346.90 | 3.79 | 3.79 |
| 376.43 | 4.97 | 4.97 |
| 347.84 | 4.08 | 4.08 |
| 318.33 | 4.39 | 4.39 |
| 394.43 | 3.54 | 3.54 |
| 382.87 | 2.65 | 2.65 |
| 484.60 | 5.96 | 5.96 |
| 463.96 | 4.65 | 4.65 |
| 287.37 | 4.44 | 4.44 |
| 287.79 | 4.31 | 4.31 |
| 314.43 | 4.75 | 4.75 |
| 546.60 | 7.48 | 7.48 |
| 335.84 | 3.43 | 3.43 |
| 440.29 | 3.00 | 3.00 |
| 338.28 | 4.62 | 4.62 |
| 335.45 | 3.89 | 3.89 |
| 307.44 | 4.53 | 4.53 |
| 232.71 | 3.49 | 3.49 |
| 371.46 | 5.95 | 5.95 |
| 284.75 | 3.92 | 3.92 |
| 292.51 | 4.08 | 4.08 |
| 334.39 | 3.58 | 3.58 |
| 420.56 | 6.03 | 6.03 |
| 460.56 | 4.89 | 4.89 |
| 362.44 | 4.50 | 4.50 |
| 331.42 | 2.60 | 2.60 |
| 480.59 | 5.34 | 5.34 |
| 391.41 | 4.14 | 4.14 |
| 286.33 | 3.96 | 3.96 |
| 358.39 | 3.93 | 3.93 |
| 301.41 | 3.91 | 3.91 |
| 261.75 | 3.90 | 3.90 |
| 355.44 | 4.97 | 4.97 |
| 420.33 | 6.70 | 6.70 |
| 389.36 | 5.79 | 5.79 |
| 354.81 | 5.78 | 5.78 |
| 348.40 | 4.67 | 4.67 |
| 356.43 | 5.57 | 5.57 |
| 469.01 | 5.99 | 5.99 |
| 592.66 | 8.20 | 8.20 |
| 409.51 | 4.62 | 4.62 |
| 360.89 | 3.32 | 3.32 |
| 451.57 | 7.35 | 7.35 |
| 294.45 | 3.50 | 3.50 |
| 349.86 | 3.96 | 3.96 |
| 396.92 | 4.96 | 4.96 |
| 357.89 | 4.75 | 4.75 |
| 282.55 | 2.73 | 2.73 |
| 579.12 | 9.64 | 9.64 |
| 662.87 | 3.60 | 3.60 |
| 287.32 | 1.31 | 1.31 |
| 268.36 | 3.67 | 3.67 |
| 308.36 | 4.28 | 4.28 |
| 289.34 | 4.03 | 4.03 |
| 290.25 | 2.92 | 2.92 |
| 245.28 | 2.27 | 2.27 |
| 320.40 | 4.15 | 4.15 |
| 480.59 | 7.28 | 7.28 |
| 357.25 | 5.45 | 5.45 |
| 335.32 | 3.56 | 3.56 |
| 309.41 | 3.34 | 3.34 |
| 637.73 | 5.50 | 5.50 |
| 420.51 | 3.92 | 3.92 |
| 308.39 | 3.39 | 3.39 |
| 245.32 | 3.60 | 3.60 |
| 279.34 | 3.29 | 3.29 |
| 312.19 | 2.55 | 2.55 |
| 265.40 | 2.82 | 2.82 |
| 382.25 | 5.79 | 5.79 |
| 657.77 | 7.70 | 7.70 |
| 273.72 | 3.53 | 3.53 |
| 410.43 | 1.58 | 1.58 |
| 500.19 | 5.13 | 5.13 |
| 359.48 | 3.73 | 3.73 |
| 349.22 | 4.08 | 4.08 |
| 274.32 | 2.76 | 2.76 |
| 524.58 | 7.52 | 7.52 |
| 362.27 | 3.63 | 3.63 |
| 621.78 | 7.23 | 7.23 |
| 501.37 | 7.04 | 7.04 |
| 426.59 | 6.09 | 6.09 |
| 631.73 | 7.20 | 7.20 |
| 406.51 | 5.01 | 5.01 |
| 286.76 | 4.34 | 4.34 |
| 357.81 | 2.13 | 2.13 |
| 348.19 | 5.21 | 5.21 |
| 469.31 | 3.61 | 3.61 |
| 305.85 | 3.63 | 3.63 |
| 389.54 | 4.17 | 4.17 |
| 380.36 | 4.82 | 4.82 |
| 559.64 | 6.40 | 6.40 |
| 416.52 | 4.17 | 4.17 |
| 312.41 | 2.72 | 2.72 |
| 390.51 | 4.42 | 4.42 |
| 448.59 | 5.01 | 5.01 |
| 291.82 | 3.07 | 3.07 |
| 254.33 | 3.28 | 3.28 |
| 368.91 | 5.09 | 5.09 |
| 286.20 | 4.11 | 4.11 |
| 282.16 | 2.54 | 2.54 |
| 366.89 | 3.95 | 3.95 |
| 434.56 | 5.33 | 5.33 |
| 293.53 | 3.63 | 3.63 |
| 336.39 | 4.03 | 4.03 |
| 462.62 | 5.40 | 5.40 |
| 432.91 | 5.43 | 5.43 |
| 414.49 | 4.73 | 4.73 |
| 377.91 | 4.04 | 4.04 |
| 417.44 | 4.96 | 4.96 |
| 468.47 | 5.09 | 5.09 |
| 411.96 | 5.82 | 5.82 |
| 293.32 | 3.76 | 3.76 |
| 310.42 | 4.85 | 4.85 |
| 303.79 | 4.09 | 4.09 |
| 436.01 | 5.10 | 5.10 |
| 391.90 | 4.48 | 4.48 |
| 411.63 | 4.27 | 4.27 |
| 360.24 | 4.22 | 4.22 |
| 367.41 | 4.09 | 4.09 |
| 314.47 | 3.79 | 3.79 |
| 458.86 | 5.49 | 5.49 |
| 333.58 | 5.43 | 5.43 |
| 327.43 | 4.18 | 4.18 |
| 363.46 | 4.65 | 4.65 |
| 314.82 | 4.55 | 4.55 |
| 453.58 | 3.84 | 3.84 |
| 395.53 | 5.20 | 5.20 |
| 355.95 | 3.72 | 3.72 |
| 425.96 | 4.84 | 4.84 |
| 458.63 | 4.56 | 4.56 |
| 281.14 | 4.29 | 4.29 |
| 278.71 | 4.43 | 4.43 |
| 400.46 | 4.42 | 4.42 |
| 315.84 | 4.99 | 4.99 |
| 352.79 | 5.61 | 5.61 |
| 425.96 | 4.84 | 4.84 |
| 450.58 | 5.35 | 5.35 |
| 350.85 | 5.53 | 5.53 |
| 315.68 | 4.32 | 4.32 |
| 416.29 | 4.16 | 4.16 |
| 321.80 | 3.40 | 3.40 |
| 383.49 | 3.79 | 3.79 |
| 487.03 | 3.59 | 3.59 |
| 417.98 | 4.25 | 4.25 |
| 308.43 | 3.69 | 3.69 |
| 395.73 | 4.13 | 4.13 |
| 297.24 | 2.35 | 2.35 |
| 279.41 | 3.29 | 3.29 |
| 384.50 | 3.67 | 3.67 |
| 398.46 | 5.24 | 5.24 |
| 401.89 | 5.65 | 5.65 |
| 403.95 | 3.86 | 3.86 |
| 472.47 | 4.43 | 4.43 |
| 440.55 | 4.76 | 4.76 |
| 329.84 | 3.61 | 3.61 |
| 309.33 | 2.18 | 2.18 |
| 368.40 | 3.79 | 3.79 |
| 392.42 | 2.28 | 2.28 |
| 468.11 | 8.20 | 8.20 |
| 431.37 | 4.60 | 4.60 |
| 363.89 | 4.35 | 4.35 |
| 254.31 | 1.62 | 1.62 |
| 254.27 | 3.09 | 3.09 |
| 335.83 | 3.57 | 3.57 |
| 393.31 | 4.23 | 4.23 |
| 280.33 | 4.00 | 4.00 |
| 310.38 | 3.59 | 3.59 |
| 358.44 | 6.34 | 6.34 |
| 321.31 | 3.81 | 3.81 |
| 341.33 | 0.31 | 0.31 |
| 490.67 | 5.47 | 5.47 |
| 380.49 | 3.69 | 3.69 |
| 519.98 | 5.52 | 5.52 |
| 487.69 | 6.59 | 6.59 |
| 485.65 | 6.65 | 6.65 |
| 489.52 | 5.36 | 5.36 |
| 420.49 | 4.83 | 4.83 |
| 401.51 | 4.70 | 4.70 |
| 396.48 | 5.11 | 5.11 |
| 492.91 | 5.81 | 5.81 |
| 476.91 | 6.11 | 6.11 |
| 472.45 | 5.30 | 5.30 |
| 317.82 | 3.52 | 3.52 |
| 301.78 | 2.52 | 2.52 |
| 311.39 | 4.85 | 4.85 |
| 491.95 | 5.68 | 5.68 |
| 341.41 | 4.86 | 4.86 |
| 484.60 | 6.20 | 6.20 |
| 405.48 | 3.93 | 3.93 |
| 352.44 | 2.43 | 2.43 |
| 348.31 | 4.54 | 4.54 |
| 465.47 | 4.32 | 4.32 |
| 389.88 | 6.11 | 6.11 |
| 493.57 | 5.11 | 5.11 |
| 313.36 | 2.81 | 2.81 |