Basic Information
ID: ALA3301557
Type: Functional
Description: MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. The IC50 value was extrapolated as the concentration that induced a 50% inhibition of gametocyte viability.
Organism: Plasmodium falciparum
Strain: 3D7
Activity Charts
Bioactivity
Activity Types for Assay ALA3301557
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 368.48 | 4.88 | 4.88 |
| 279.39 | 3.75 | 3.75 |
| 288.31 | 3.36 | 3.36 |
| 267.36 | 4.26 | 4.26 |
| 347.26 | 3.78 | 3.78 |
| 367.41 | 2.53 | 2.53 |
| 479.85 | 3.90 | 3.90 |
| 497.75 | 4.59 | 4.59 |
| 574.24 | 5.29 | 5.29 |
| 354.41 | 4.46 | 4.46 |
| 312.42 | 4.34 | 4.34 |
| 420.18 | 4.45 | 4.45 |
| 487.77 | 6.43 | 6.43 |
| 507.05 | 4.87 | 4.87 |
| 462.43 | 3.68 | 3.68 |
| 726.97 | 5.87 | 5.87 |
| 515.15 | 7.63 | 7.63 |
| 457.83 | 4.30 | 4.30 |
| 280.17 | 3.96 | 3.96 |
| 362.43 | 3.88 | 3.88 |
| 419.48 | 6.33 | 6.33 |
| 496.69 | 5.56 | 5.56 |
| 346.90 | 3.79 | 3.79 |
| 394.43 | 3.54 | 3.54 |
| 287.37 | 4.44 | 4.44 |
| 546.60 | 7.48 | 7.48 |
| 292.51 | 4.08 | 4.08 |
| 662.87 | 3.60 | 3.60 |
| 335.32 | 3.56 | 3.56 |
| 309.41 | 3.34 | 3.34 |
| 389.54 | 4.17 | 4.17 |
| 432.91 | 5.43 | 5.43 |
| 327.43 | 4.18 | 4.18 |
| 425.96 | 4.84 | 4.84 |
| 425.96 | 4.84 | 4.84 |
| 416.29 | 4.16 | 4.16 |
| 440.55 | 4.76 | 4.76 |
| 348.31 | 4.54 | 4.54 |
| 465.47 | 4.32 | 4.32 |