Basic Information
ID: ALA3367601
Type: Binding
Description: Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis relative to apo-RORc ligand binding domain
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3367601
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 471.64 | 4.75 | 4.75 |
| 479.67 | 2.76 | 2.76 |
| 494.68 | 2.26 | 2.26 |
| 493.70 | 2.80 | 2.80 |
| 450.63 | 2.91 | 2.91 |
| 402.56 | 3.51 | 3.51 |
| 415.60 | 3.43 | 3.43 |
| 416.59 | 3.64 | 3.64 |
| 430.61 | 4.29 | 4.29 |
| 425.60 | 4.41 | 4.41 |
| 443.61 | 3.38 | 3.38 |
| 471.67 | 3.98 | 3.98 |
| 443.61 | 3.34 | 3.34 |
| 459.61 | 3.56 | 3.56 |
| 457.64 | 3.78 | 3.78 |
| 441.60 | 3.24 | 3.24 |
| 443.61 | 3.49 | 3.49 |
| 443.57 | 2.09 | 2.09 |
| 429.59 | 3.10 | 3.10 |
| 429.59 | 3.10 | 3.10 |
| 427.57 | 2.85 | 2.85 |
| 415.56 | 2.71 | 2.71 |
| 469.53 | 3.25 | 3.25 |
| 445.59 | 2.33 | 2.33 |