Basic Information
ID: ALA3372264
Type: Toxicity
Description: safety index, ratio of toxicity in anesthetized cardiovascular beagle dog model assessed as increase in QTc interval at doses 35 mg/kg, iv dosed through 30 mins infusion to fEC50 for reduction in amyloid beta production in Sprague-Dawley rat brain at 30 mg/kg, po by indirect response model
Format: BAO_0000218
Tissue: Heart
Target: Unchecked(ALA612545)
Document: ALA3351923
safety index, ratio of toxicity in anesthetized cardiovascular beagle dog model assessed as increase in QTc interval at doses 35 mg/kg, iv dosed through 30 mins infusion to fEC50 for reduction in amyloid beta production in Sprague-Dawley rat brain at 30 mg/kg, po by indirect response model: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3372264
TI
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 447.44 | 4.52 | 4.52 |