Basic Information
ID: ALA3378733
Type: Binding
Description: Competitive binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) assessed as inhibition of eIF4E/eIF4G interaction by fluorescence polarization assay relative to parent compound
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3378733
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 451.29 | 5.12 | 5.12 |
| 451.29 | 5.12 | 5.12 |
| 451.29 | 5.12 | 5.12 |
| 451.29 | 5.12 | 5.12 |
| 451.29 | 5.12 | 5.12 |
| 451.29 | 5.12 | 5.12 |
| 406.29 | 5.21 | 5.21 |
| 406.29 | 5.21 | 5.21 |
| 422.29 | 4.92 | 4.92 |
| 422.29 | 4.92 | 4.92 |
| 450.30 | 4.91 | 4.91 |
| 450.30 | 4.91 | 4.91 |
| 421.31 | 4.79 | 4.79 |
| 421.31 | 4.79 | 4.79 |
| 440.74 | 5.87 | 5.87 |
| 440.74 | 5.87 | 5.87 |
| 424.28 | 5.35 | 5.35 |
| 424.28 | 5.35 | 5.35 |
| 474.29 | 6.23 | 6.23 |
| 474.29 | 6.23 | 6.23 |
| 466.31 | 4.70 | 4.70 |
| 466.31 | 4.70 | 4.70 |
| 495.30 | 4.82 | 4.82 |
| 495.30 | 4.82 | 4.82 |
| 467.29 | 4.83 | 4.83 |
| 467.29 | 4.83 | 4.83 |
| 481.32 | 5.13 | 5.13 |
| 481.32 | 5.13 | 5.13 |
| 530.19 | 5.88 | 5.88 |
| 530.19 | 5.88 | 5.88 |
| 485.74 | 5.77 | 5.77 |
| 485.74 | 5.77 | 5.77 |
| 469.28 | 5.26 | 5.26 |
| 469.28 | 5.26 | 5.26 |
| 382.40 | 3.81 | 3.81 |
| 382.40 | 3.81 | 3.81 |
| 398.40 | 3.52 | 3.52 |
| 398.40 | 3.52 | 3.52 |
| 426.41 | 3.51 | 3.51 |
| 426.41 | 3.51 | 3.51 |
| 397.42 | 3.40 | 3.40 |
| 397.42 | 3.40 | 3.40 |
| 467.51 | 3.65 | 3.65 |
| 467.51 | 3.65 | 3.65 |
| 451.51 | 4.41 | 4.41 |
| 464.55 | 5.86 | 5.86 |
| 464.55 | 5.86 | 5.86 |
| 458.50 | 5.48 | 5.48 |
| 432.46 | 4.97 | 4.97 |
| 432.46 | 4.97 | 4.97 |
| 423.41 | 4.76 | 4.76 |
| 423.41 | 4.76 | 4.76 |
| 461.30 | 4.58 | 4.58 |
| 461.30 | 4.58 | 4.58 |