Basic Information
ID: ALA3380864
Type: Functional
Description: Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
Organism: Homo sapiens
Cell type: CHO
Activity Charts
Bioactivity
Activity Types for Assay ALA3380864
pIC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 424.83 | 4.43 | 4.43 |
| 448.47 | 4.56 | 4.56 |
| 434.40 | 3.51 | 3.51 |
| 438.41 | 3.93 | 3.93 |
| 454.86 | 4.44 | 4.44 |
| 434.44 | 4.09 | 4.09 |
| 438.41 | 3.93 | 3.93 |
| 454.86 | 4.44 | 4.44 |
| 434.44 | 4.09 | 4.09 |
| 452.43 | 4.32 | 4.32 |
| 466.46 | 4.70 | 4.70 |
| 452.39 | 3.65 | 3.65 |
| 456.40 | 4.06 | 4.06 |
| 472.85 | 4.58 | 4.58 |
| 452.43 | 4.23 | 4.23 |
| 456.40 | 4.06 | 4.06 |
| 472.85 | 4.58 | 4.58 |
| 452.43 | 4.23 | 4.23 |
| 456.54 | 4.69 | 4.69 |
| 470.57 | 5.07 | 5.07 |
| 456.50 | 4.02 | 4.02 |
| 460.51 | 4.43 | 4.43 |
| 476.96 | 4.95 | 4.95 |
| 456.54 | 4.60 | 4.60 |
| 460.51 | 4.43 | 4.43 |
| 476.96 | 4.95 | 4.95 |
| 456.54 | 4.60 | 4.60 |
| 452.43 | 4.23 | 4.23 |
| 452.43 | 4.23 | 4.23 |
| 418.88 | 4.16 | 4.16 |
| 418.88 | 4.16 | 4.16 |
| 418.88 | 4.16 | 4.16 |
| 432.91 | 4.55 | 4.55 |
| 446.93 | 4.94 | 4.94 |
| 442.82 | 4.57 | 4.57 |
| 431.92 | 4.22 | 4.22 |
| 407.83 | 3.69 | 3.69 |
| 407.83 | 3.69 | 3.69 |
| 390.83 | 2.94 | 2.94 |
| 425.82 | 3.83 | 3.83 |
| 420.42 | 3.79 | 3.79 |
| 420.42 | 3.79 | 3.79 |
| 420.42 | 3.79 | 3.79 |
| 482.49 | 5.57 | 5.57 |
| 396.44 | 4.31 | 4.31 |
| 382.41 | 3.92 | 3.92 |
| 368.38 | 3.53 | 3.53 |
| 354.36 | 3.14 | 3.14 |
| 398.41 | 3.16 | 3.16 |
| 391.38 | 3.17 | 3.17 |
| 391.38 | 3.17 | 3.17 |
| 391.38 | 3.17 | 3.17 |
| 434.44 | 4.18 | 4.18 |