Basic Information
ID: ALA3388443
Type: Binding
Description: Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumption
Format: BAO_0000019
Organism: Homo sapiens
Target: Isocitrate dehydrogenase [NADP] cytoplasmic(ALA2007625)
Document: ALA3351758
Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumption: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3388443
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 200.24 | 2.69 | 2.69 |
| 207.27 | 2.44 | 2.44 |
| 187.20 | 1.75 | 1.75 |
| 202.21 | 1.48 | 1.48 |
| 190.20 | 0.94 | 0.94 |
| 202.21 | 1.94 | 1.94 |
| 218.21 | 0.30 | 0.30 |
| 139.15 | 0.70 | 0.70 |
| 203.24 | 1.69 | 1.69 |
| 215.25 | 1.98 | 1.98 |
| 231.25 | 1.69 | 1.69 |
| 201.22 | 1.68 | 1.68 |
| 243.31 | 2.80 | 2.80 |
| 215.25 | 1.87 | 1.87 |
| 229.28 | 2.26 | 2.26 |
| 203.20 | 1.88 | 1.88 |
| 170.12 | -0.80 | -0.80 |
| 244.25 | 1.02 | 1.02 |
| 244.25 | 1.27 | 1.27 |
| 187.20 | 1.75 | 1.75 |
| 215.25 | 2.24 | 2.24 |
| 215.25 | 1.87 | 1.87 |
| 273.29 | 1.66 | 1.66 |
| 170.12 | -0.80 | -0.80 |
| 231.25 | 1.97 | 1.97 |
| 215.25 | 1.98 | 1.98 |
| 245.28 | 1.99 | 1.99 |
| 231.25 | 1.69 | 1.69 |
| 217.22 | 1.38 | 1.38 |
| 231.25 | 1.68 | 1.68 |
| 231.25 | 1.17 | 1.17 |
| 273.29 | 1.74 | 1.74 |
| 245.28 | 1.99 | 1.99 |
| 245.28 | 1.99 | 1.99 |
| 231.25 | 1.69 | 1.69 |
| 245.28 | 1.99 | 1.99 |
| 231.25 | 1.69 | 1.69 |
| 233.24 | 2.12 | 2.12 |
| 305.20 | 2.68 | 2.68 |
| 240.26 | 1.86 | 1.86 |
| 240.26 | 1.86 | 1.86 |
| 259.26 | 1.68 | 1.68 |
| 258.28 | 1.08 | 1.08 |
| 283.25 | 3.00 | 3.00 |
| 243.31 | 2.60 | 2.60 |
| 221.28 | 2.05 | 2.05 |
| 291.35 | 3.65 | 3.65 |
| 307.35 | 3.78 | 3.78 |
| 265.31 | 3.14 | 3.14 |
| 295.34 | 3.15 | 3.15 |
| 281.31 | 2.84 | 2.84 |
| 271.34 | 3.20 | 3.20 |
| 321.38 | 3.66 | 3.66 |
| 307.35 | 3.36 | 3.36 |
| 321.38 | 3.66 | 3.66 |
| 307.35 | 3.36 | 3.36 |
| 367.45 | 5.32 | 5.32 |
| 185.23 | 1.97 | 1.97 |
| 214.27 | 1.46 | 1.46 |
| 200.24 | 2.54 | 2.54 |
| 216.31 | 3.91 | 3.91 |