Basic Information
ID: ALA3389009
Type: Binding
Description: Inhibition of IDH1 R132C mutant in human HT1080 cells assessed as reduction in D2HG production incubated for 48 hrs by HPLC-MS method
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HT-1080
Target: Isocitrate dehydrogenase [NADP] cytoplasmic(ALA2007625)
Document: ALA3351758
Inhibition of IDH1 R132C mutant in human HT1080 cells assessed as reduction in D2HG production incubated for 48 hrs by HPLC-MS method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3389009
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 203.24 | 1.69 | 1.69 |
| 215.25 | 1.98 | 1.98 |
| 231.25 | 1.69 | 1.69 |
| 201.22 | 1.68 | 1.68 |
| 243.31 | 2.80 | 2.80 |
| 170.12 | -0.80 | -0.80 |
| 217.22 | 1.38 | 1.38 |
| 245.28 | 1.99 | 1.99 |
| 231.25 | 1.69 | 1.69 |
| 321.38 | 3.66 | 3.66 |
| 307.35 | 3.36 | 3.36 |
| 321.38 | 3.66 | 3.66 |