Basic Information
ID: ALA3392925
Type: Toxicity
Description: MMV: Selection for compounds that exhibit enhanced toxicity in combination with artemisinin. Assay utilized the disc diffusion method with the observance of a clear zone indicating inhibition of growth. Synthetic complete medium containing 3% glycerol as a carbon source (SCG) was used in each assay. 10 uL of each compound was added to a paper disc which was placed on SCG and SCG+Artemisinin (0.2 uM) plates seeded with 10e6 yeast cells (WC081 strain: Mat a, leu2 delta 0, lys2 delta 0, ura3 delta 0, his3 delta 1, pdr1 delta::HIS3, pdr3 delta::kanMX4, derived from BY4742, regulators of Multi-drug resistance transporters have been deleted to enhance toxicity of compounds). Plates were incubated at 30 degrees C for 5 days and clear zones were measured. Compounds that produced a larger clear zone in the presence of artemisinin was considered to have an additive interaction with artemisinin. Results are reported as diameter of clear zone on SCG+artemisinin plates - diameter of clear zone on SCG plates without artemisinin.
Organism: Saccharomyces cerevisiae
Strain: WC081
Activity Charts
Bioactivity
Activity Types for Assay ALA3392925
IZ
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 277.80 | 3.64 | 3.64 |
| 368.48 | 4.88 | 4.88 |
| 279.39 | 3.75 | 3.75 |
| 245.28 | 2.68 | 2.68 |
| 272.31 | 3.66 | 3.66 |
| 267.36 | 4.26 | 4.26 |
| 319.45 | 4.59 | 4.59 |
| 275.31 | 3.33 | 3.33 |
| 273.33 | 2.44 | 2.44 |
| 346.40 | 3.33 | 3.33 |
| 361.23 | 4.16 | 4.16 |
| 359.41 | 1.47 | 1.47 |
| 249.75 | 2.91 | 2.91 |
| 510.43 | 7.68 | 7.68 |
| 571.68 | 7.18 | 7.18 |
| 476.05 | 7.29 | 7.29 |
| 367.41 | 2.53 | 2.53 |
| 398.51 | 5.20 | 5.20 |
| 413.53 | 4.11 | 4.11 |
| 307.86 | 3.70 | 3.70 |
| 420.49 | 3.68 | 3.68 |
| 397.50 | 4.24 | 4.24 |
| 261.41 | 4.11 | 4.11 |
| 456.51 | 4.03 | 4.03 |
| 377.87 | 4.09 | 4.09 |
| 309.82 | 3.80 | 3.80 |
| 326.45 | 4.46 | 4.46 |
| 292.34 | 3.42 | 3.42 |
| 281.28 | 2.92 | 2.92 |
| 389.80 | 3.67 | 3.67 |
| 286.77 | 3.26 | 3.26 |
| 459.93 | 6.39 | 6.39 |
| 309.32 | 3.38 | 3.38 |
| 322.45 | 4.08 | 4.08 |
| 341.72 | 4.16 | 4.16 |
| 370.49 | 3.80 | 3.80 |
| 329.38 | 2.38 | 2.38 |
| 340.40 | 3.76 | 3.76 |
| 459.62 | 4.69 | 4.69 |
| 327.70 | 3.85 | 3.85 |
| 367.53 | 5.10 | 5.10 |
| 426.54 | 4.88 | 4.88 |
| 353.38 | 1.40 | 1.40 |
| 228.34 | 3.17 | 3.17 |
| 453.55 | 8.40 | 8.40 |
| 460.54 | 6.38 | 6.38 |
| 380.44 | 4.79 | 4.79 |
| 328.20 | 2.53 | 2.53 |
| 362.43 | 3.88 | 3.88 |
| 293.32 | 3.78 | 3.78 |
| 463.96 | 4.65 | 4.65 |
| 287.79 | 4.31 | 4.31 |
| 334.39 | 3.58 | 3.58 |
| 355.44 | 4.97 | 4.97 |
| 469.01 | 5.99 | 5.99 |
| 592.66 | 8.20 | 8.20 |
| 409.51 | 4.62 | 4.62 |
| 360.89 | 3.32 | 3.32 |
| 637.73 | 5.50 | 5.50 |
| 308.39 | 3.39 | 3.39 |
| 279.34 | 3.29 | 3.29 |
| 312.19 | 2.55 | 2.55 |
| 657.77 | 7.70 | 7.70 |
| 621.78 | 7.23 | 7.23 |
| 631.73 | 7.20 | 7.20 |
| 389.54 | 4.17 | 4.17 |
| 434.56 | 5.33 | 5.33 |
| 293.53 | 3.63 | 3.63 |
| 367.41 | 4.09 | 4.09 |
| 327.43 | 4.18 | 4.18 |
| 314.82 | 4.55 | 4.55 |
| 329.84 | 3.61 | 3.61 |
| 309.33 | 2.18 | 2.18 |
| 468.11 | 8.20 | 8.20 |
| 254.31 | 1.62 | 1.62 |
| 321.31 | 3.81 | 3.81 |
| 396.48 | 5.11 | 5.11 |
| 492.91 | 5.81 | 5.81 |
| 476.91 | 6.11 | 6.11 |
| 317.82 | 3.52 | 3.52 |