Basic Information
ID: ALA3418719
Type: Binding
Description: Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP induction measured after 30 mins by ELISA
Organism: Homo sapiens
Cell type: THP-1
Activity Charts
Bioactivity
Activity Types for Assay ALA3418719
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 721.86 | 5.13 | 5.13 |
| 397.41 | 1.75 | 1.75 |
| 598.73 | 4.77 | 4.77 |
| 590.70 | 4.04 | 4.04 |
| 642.78 | 4.67 | 4.67 |
| 494.57 | 2.46 | 2.46 |
| 570.67 | 4.13 | 4.13 |
| 656.80 | 5.06 | 5.06 |
| 721.67 | 5.19 | 5.19 |
| 670.83 | 5.45 | 5.45 |
| 628.75 | 4.28 | 4.28 |
| 616.74 | 4.28 | 4.28 |
| 619.10 | 4.42 | 4.42 |
| 619.10 | 4.42 | 4.42 |
| 602.64 | 3.91 | 3.91 |
| 620.63 | 4.05 | 4.05 |
| 653.54 | 5.08 | 5.08 |
| 687.10 | 5.44 | 5.44 |
| 637.09 | 4.56 | 4.56 |
| 701.12 | 5.78 | 5.78 |
| 715.15 | 6.17 | 6.17 |
| 729.18 | 6.56 | 6.56 |
| 729.18 | 6.56 | 6.56 |
| 628.75 | 4.80 | 4.80 |
| 642.78 | 5.19 | 5.19 |
| 673.07 | 5.57 | 5.57 |