Basic Information
ID: ALA3418720
Type: Binding
Description: Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release at 1 uM preincubated for 30 mins followed by BzATP induction measured after 30 mins by ELISA relative to control
Organism: Homo sapiens
Cell type: THP-1
Activity Charts
Bioactivity
Activity Types for Assay ALA3418720
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 608.72 | 4.50 | 4.50 |
| 612.71 | 4.41 | 4.41 |
| 536.61 | 2.87 | 2.87 |
| 550.64 | 3.11 | 3.11 |
| 564.66 | 3.50 | 3.50 |
| 550.64 | 3.26 | 3.26 |
| 564.66 | 3.50 | 3.50 |
| 735.86 | 6.57 | 6.57 |
| 725.87 | 6.84 | 6.84 |
| 735.86 | 6.57 | 6.57 |
| 538.59 | 4.21 | 4.21 |
| 594.69 | 4.11 | 4.11 |
| 538.59 | 4.21 | 4.21 |
| 584.70 | 4.38 | 4.38 |
| 594.69 | 4.11 | 4.11 |
| 580.66 | 3.86 | 3.86 |
| 584.65 | 3.77 | 3.77 |
| 598.68 | 4.02 | 4.02 |
| 628.79 | 5.15 | 5.15 |
| 656.80 | 5.06 | 5.06 |
| 721.67 | 5.19 | 5.19 |
| 628.75 | 4.28 | 4.28 |
| 616.74 | 4.28 | 4.28 |
| 644.71 | 3.79 | 3.79 |
| 619.10 | 4.42 | 4.42 |
| 687.10 | 5.44 | 5.44 |