Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pre...

Basic Information

ID: ALA3420867

Type: Binding

Description: Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pre-incubated for 15 mins followed by stimulation with A23187 for 10 mins by RP-HPLC based cell based assay

Format: BAO_0000219

Organism: Homo sapiens

Target: Arachidonate 5-lipoxygenase(ALA215)

Document: ALA3414543

Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pre-incubated for 15 mins followed by stimulation with A23187 for 10 mins by RP-HPLC based cell based assay: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA3420867

IC50

Total(49)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
236.30	2.73	2.73
294.39	4.31	4.31
252.31	3.14	3.14
322.45	5.09	5.09
350.50	5.87	5.87
308.42	4.40	4.40
350.50	5.57	5.57
308.42	4.10	4.10
336.47	5.18	5.18
322.44	4.49	4.49
224.26	2.36	2.36
196.20	1.58	1.58
280.36	3.92	3.92
308.42	4.70	4.70
336.47	5.48	5.48
364.53	6.26	6.26
276.33	3.48	3.48
344.45	5.20	5.20
210.23	1.67	1.67
238.28	2.45	2.45
266.34	3.23	3.23
294.39	4.01	4.01
322.45	4.79	4.79
364.53	5.96	5.96
378.55	6.35	6.35
290.36	3.56	3.56
358.48	5.29	5.29
224.26	1.76	1.76
252.31	2.54	2.54
280.36	3.32	3.32
336.47	4.88	4.88
350.50	5.27	5.27
364.53	5.66	5.66
378.55	6.05	6.05
392.58	6.44	6.44
304.39	3.65	3.65
372.51	5.38	5.38
224.26	1.76	1.76
252.31	2.54	2.54
280.36	3.32	3.32
308.42	4.10	4.10
322.44	4.49	4.49
336.47	4.88	4.88
350.50	5.27	5.27
364.53	5.66	5.66
378.55	6.05	6.05
392.58	6.44	6.44
304.39	3.65	3.65
372.51	5.38	5.38