Basic Information
ID: ALA3421244
Type: Binding
Description: Inhibition of DOT1L in human MV4-11 cells expressing MLL-AF4 assessed as reduction of H3K79me2 level at 1 uM after 3 to 4 days by immunoblot analysis relative to control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: MV4-11
Target: Histone-lysine N-methyltransferase, H3 lysine-79 specific(ALA1795117)
Document: ALA3414551
Inhibition of DOT1L in human MV4-11 cells expressing MLL-AF4 assessed as reduction of H3K79me2 level at 1 uM after 3 to 4 days by immunoblot analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3421244
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 562.72 | 3.32 | 3.32 |