Basic Information
ID: ALA3424026
Type: Binding
Description: Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins before icilin stimulation by Fluo-4-AM dye based spectrofluorimetry
Organism: Rattus norvegicus
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA3424026
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 311.30 | 2.87 | 2.87 |
| 325.32 | 3.17 | 3.17 |
| 302.72 | 3.90 | 3.90 |
| 311.30 | 2.87 | 2.87 |
| 311.30 | 2.87 | 2.87 |
| 325.32 | 3.17 | 3.17 |
| 325.32 | 3.17 | 3.17 |
| 325.32 | 3.18 | 3.18 |
| 325.32 | 3.18 | 3.18 |
| 325.32 | 2.66 | 2.66 |
| 325.32 | 2.66 | 2.66 |
| 338.32 | 2.26 | 2.26 |
| 366.38 | 2.92 | 2.92 |
| 388.41 | 2.54 | 2.54 |
| 313.29 | 3.30 | 3.30 |
| 329.74 | 3.82 | 3.82 |
| 374.19 | 3.93 | 3.93 |
| 421.19 | 3.77 | 3.77 |
| 329.74 | 3.82 | 3.82 |
| 374.19 | 3.93 | 3.93 |
| 421.19 | 3.77 | 3.77 |
| 325.32 | 3.26 | 3.26 |
| 339.35 | 3.52 | 3.52 |
| 311.30 | 2.87 | 2.87 |
| 311.30 | 2.87 | 2.87 |
| 311.30 | 2.87 | 2.87 |
| 325.32 | 3.17 | 3.17 |
| 325.32 | 3.18 | 3.18 |
| 338.32 | 2.26 | 2.26 |
| 297.27 | 2.45 | 2.45 |
| 311.30 | 2.75 | 2.75 |
| 374.38 | 2.11 | 2.11 |
| 292.34 | 3.28 | 3.28 |
| 306.37 | 3.58 | 3.58 |
| 337.34 | 3.19 | 3.19 |
| 337.34 | 3.19 | 3.19 |
| 284.27 | 2.95 | 2.95 |
| 284.27 | 2.95 | 2.95 |
| 298.30 | 3.26 | 3.26 |
| 298.30 | 3.26 | 3.26 |
| 298.30 | 2.74 | 2.74 |
| 298.30 | 2.74 | 2.74 |
| 347.17 | 4.01 | 4.01 |
| 394.17 | 3.85 | 3.85 |
| 302.72 | 3.90 | 3.90 |
| 347.17 | 4.01 | 4.01 |
| 394.17 | 3.85 | 3.85 |
| 396.18 | 3.77 | 3.77 |
| 282.30 | 3.56 | 3.56 |
| 282.30 | 3.56 | 3.56 |
| 310.35 | 4.37 | 4.37 |
| 310.35 | 4.37 | 4.37 |
| 324.38 | 4.54 | 4.54 |
| 361.38 | 2.62 | 2.62 |