Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins b...

Basic Information

ID: ALA3424026

Type: Binding

Description: Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins before icilin stimulation by Fluo-4-AM dye based spectrofluorimetry

Format: BAO_0000219

Organism: Rattus norvegicus

Cell type: HEK293

Target: Transient receptor potential cation channel subfamily M member 8(ALA5011)

Document: ALA3421598

Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins before icilin stimulation by Fluo-4-AM dye based spectrofluorimetry: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA3424026

IC50

Total(54)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
311.30	2.87	2.87
325.32	3.17	3.17
302.72	3.90	3.90
311.30	2.87	2.87
311.30	2.87	2.87
325.32	3.17	3.17
325.32	3.17	3.17
325.32	3.18	3.18
325.32	3.18	3.18
325.32	2.66	2.66
325.32	2.66	2.66
338.32	2.26	2.26
366.38	2.92	2.92
388.41	2.54	2.54
313.29	3.30	3.30
329.74	3.82	3.82
374.19	3.93	3.93
421.19	3.77	3.77
329.74	3.82	3.82
374.19	3.93	3.93
421.19	3.77	3.77
325.32	3.26	3.26
339.35	3.52	3.52
311.30	2.87	2.87
311.30	2.87	2.87
311.30	2.87	2.87
325.32	3.17	3.17
325.32	3.18	3.18
338.32	2.26	2.26
297.27	2.45	2.45
311.30	2.75	2.75
374.38	2.11	2.11
292.34	3.28	3.28
306.37	3.58	3.58
337.34	3.19	3.19
337.34	3.19	3.19
284.27	2.95	2.95
284.27	2.95	2.95
298.30	3.26	3.26
298.30	3.26	3.26
298.30	2.74	2.74
298.30	2.74	2.74
347.17	4.01	4.01
394.17	3.85	3.85
302.72	3.90	3.90
347.17	4.01	4.01
394.17	3.85	3.85
396.18	3.77	3.77
282.30	3.56	3.56
282.30	3.56	3.56
310.35	4.37	4.37
310.35	4.37	4.37
324.38	4.54	4.54
361.38	2.62	2.62