Basic Information
ID: ALA3429503
Type: Binding
Description: Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after 25 mins by fluorescence polarization assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3429503
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 201.22 | 1.85 | 1.85 |
| 231.28 | 2.15 | 2.15 |
| 194.22 | 1.20 | 1.20 |
| 308.34 | 2.83 | 2.83 |
| 199.21 | -0.31 | -0.31 |
| 259.30 | 1.68 | 1.68 |
| 217.22 | 1.04 | 1.04 |
| 187.20 | 1.54 | 1.54 |
| 231.25 | 1.34 | 1.34 |
| 245.28 | 1.65 | 1.65 |
| 245.28 | 1.65 | 1.65 |
| 229.28 | 2.47 | 2.47 |
| 273.33 | 2.38 | 2.38 |
| 293.32 | 2.70 | 2.70 |
| 293.32 | 2.70 | 2.70 |
| 263.30 | 3.21 | 3.21 |
| 277.32 | 3.52 | 3.52 |
| 339.39 | 4.88 | 4.88 |
| 305.38 | 4.33 | 4.33 |
| 307.35 | 3.26 | 3.26 |
| 369.42 | 4.29 | 4.29 |
| 335.40 | 4.04 | 4.04 |
| 335.40 | 3.90 | 3.90 |
| 306.37 | 2.71 | 2.71 |
| 278.31 | 2.82 | 2.82 |
| 307.11 |