Assay Report Card

Basic Information

ID: ALA3431452

Type: Functional

Description: GSK_TCAKS: pIC50 Leishmania donovani Imaging: Amastigotes/Macrophages. Assay plates (384-well) were prepared by adding 250nL of compound to each well. For single shot assay, the final compound concentration was 5 uM. For potency determinations, eleven-point one in three dilution curves were generated with a top concentration of 50 uM. Two exposure images were taken for each well using 405 nm and 488 nm laser excitation. Automated image analysis was performed with a script developed on Acapella High Content Imaging and Analysis Software (PerkinElmer). Output: Average number of amastigotes per macrophage cell were reported for each well.

Organism: Homo sapiens

Cell type: THP-1

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
308.392.152.15
251.25-0.95-0.95
386.403.013.01
296.363.853.85
307.823.343.34
321.312.852.85
337.773.363.36
363.382.732.73
317.352.912.91
321.723.903.90
294.404.164.16
330.864.564.56
325.254.264.26
426.543.483.48
285.343.103.10
268.363.413.41
458.533.203.20
268.23-2.20-2.20
297.333.433.43
365.273.263.26
387.515.175.17
419.442.812.81
373.372.082.08
349.382.432.43
340.454.254.25
427.514.134.13
210.242.702.70
469.543.353.35
458.573.263.26
352.443.753.75
302.343.903.90
278.363.903.90
332.433.983.98
316.363.513.51
351.394.214.21
428.543.633.63
268.353.653.65
443.533.533.53
446.573.123.12
439.543.703.70
329.814.194.19
329.773.093.09
338.454.734.73
434.933.593.59
332.351.471.47
326.383.273.27
411.462.242.24
464.543.073.07
308.413.783.78
412.954.114.11
385.402.292.29
387.484.014.01
373.463.253.25
369.463.943.94
303.412.702.70
316.363.513.51
299.362.932.93
395.534.294.29
313.383.973.97
364.453.423.42
1310.532.972.97
582.704.704.70
482.404.824.82
442.523.473.47
267.323.313.31
258.201.231.23
291.652.482.48
326.794.084.08
326.794.084.08
292.343.433.43
357.372.052.05
337.254.734.73
376.714.334.33
685.674.284.28
506.523.013.01
371.473.343.34
296.372.752.75
211.220.710.71
497.353.873.87
474.483.103.10
486.492.762.76
502.543.623.62
504.472.522.52
549.603.983.98
541.532.682.68
544.563.313.31
450.993.843.84
441.393.743.74
456.480.550.55
467.553.663.66
466.544.274.27
393.361.941.94
541.573.793.79
489.624.004.00
471.583.673.67
418.424.034.03
242.332.902.90
349.393.923.92
387.852.052.05
295.322.722.72
335.433.953.95
325.224.174.17
325.343.493.49
568.595.315.31
450.824.444.44
434.363.933.93
346.352.392.39
302.343.723.72
525.534.434.43
362.464.014.01
388.472.712.71
400.894.014.01
324.302.752.75
321.852.722.72
296.333.423.42
327.451.281.28
425.923.943.94
439.944.334.33
302.402.792.79
409.414.444.44
299.764.234.23
293.373.613.61
485.594.134.13
455.564.124.12
469.594.514.51
259.313.603.60
378.483.373.37
400.555.215.21
339.492.952.95
389.462.272.27
226.190.150.15
409.835.065.06
315.123.473.47
311.133.333.33
388.822.462.46
366.692.522.52
359.412.952.95
403.202.642.64
336.230.440.44
541.482.432.43
339.834.584.58
285.343.893.89
450.493.403.40
341.844.264.26
463.493.733.73
388.433.993.99
326.763.883.88
341.193.983.98
365.453.943.94
402.513.873.87
381.442.692.69
459.553.383.38
307.144.394.39
392.883.353.35
326.144.554.55
605.522.992.99
642.554.324.32
464.494.684.68
413.404.404.40
366.813.693.69
361.383.973.97
373.413.553.55
634.564.074.07
396.423.513.51
320.443.583.58
309.712.262.26
484.955.115.11
331.421.721.72
379.444.344.34
310.333.453.45
375.434.304.30
329.363.723.72
396.834.254.25
387.463.513.51
355.464.114.11
461.522.782.78
432.484.674.67
388.433.703.70
497.623.943.94
403.493.673.67
415.503.833.83
309.393.183.18
479.972.812.81
469.563.423.42
260.363.693.69
382.494.024.02
395.373.013.01
468.473.983.98
333.403.123.12
291.363.713.71
321.383.723.72
361.453.633.63
361.453.553.55
377.453.253.25
572.432.262.26
1242.531.951.95
306.413.653.65
588.463.823.82
437.584.564.56
409.872.862.86
340.381.781.78
354.412.172.17
294.351.931.93
324.381.941.94
338.412.332.33
312.342.072.07
371.443.043.04
337.412.442.44
320.434.044.04
495.453.893.89
351.284.994.99
288.312.662.66
419.483.013.01
322.373.163.16
368.463.343.34
441.320.650.65
387.783.143.14
399.503.873.87
471.613.033.03
478.984.334.33
502.043.113.11
476.024.144.14
416.483.723.72
573.562.912.91
365.434.794.79
313.793.533.53
325.803.503.50
431.444.774.77
376.463.933.93
493.594.954.95
489.403.543.54
478.044.404.40
492.053.063.06
463.584.234.23
359.392.132.13
316.214.064.06
317.352.822.82
300.311.881.88
422.923.363.36
356.773.213.21
337.383.253.25
340.312.702.70
489.904.184.18
320.393.203.20
326.422.102.10
426.523.673.67
458.542.162.16
309.373.443.44
294.382.432.43
376.263.433.43
297.333.383.38
327.824.284.28
429.532.962.96
387.493.193.19
474.522.992.99
443.323.913.91
318.321.741.74
454.523.453.45
344.414.954.95
366.422.952.95
464.553.163.16
358.243.643.64
458.923.093.09
444.583.743.74
264.333.233.23
379.443.883.88
424.913.663.66
417.473.583.58
349.442.662.66
364.243.093.09
343.371.931.93
360.851.741.74
692.563.573.57
545.534.244.24
516.564.204.20
377.403.293.29
311.383.463.46
374.403.133.13
388.273.783.78
328.443.053.05
342.404.244.24
364.493.723.72
410.393.813.81
550.494.004.00
419.513.713.71
495.603.823.82
350.433.553.55
302.412.652.65
329.574.194.19
540.542.732.73
368.463.483.48
396.422.992.99
440.932.952.95
464.523.613.61
442.573.333.33
523.472.222.22
383.863.683.68
303.793.233.23
465.563.433.43
468.564.294.29
383.454.214.21
467.594.194.19
394.524.574.57
457.552.312.31
473.624.184.18
435.503.783.78
466.614.464.46
269.302.682.68
401.654.024.02
432.514.274.27
375.453.053.05
414.472.352.35
419.404.824.82
369.452.412.41
372.454.084.08
372.454.084.08
412.544.734.73
588.983.893.89
404.433.093.09
417.432.192.19
277.292.692.69
603.013.903.90
415.481.911.91
300.383.933.93
348.434.714.71
656.564.664.66
406.473.743.74
369.472.622.62
358.403.123.12
496.883.483.48
356.432.722.72
419.514.304.30
422.504.604.60
284.372.732.73
327.391.581.58
487.362.062.06
424.272.942.94
406.473.763.76
379.822.832.83
436.312.812.81
437.472.732.73
395.482.772.77
335.412.172.17
484.950.950.95
407.272.192.19
297.383.753.75
464.525.555.55
406.534.374.37
483.392.352.35
381.464.324.32
418.302.942.94
573.572.302.30
435.942.152.15
475.623.783.78
495.482.452.45
810.622.882.88
376.852.132.13
472.565.155.15
381.443.683.68
499.494.494.49
359.432.022.02
437.554.304.30
383.282.142.14
365.433.263.26
232.242.102.10
388.523.193.19
411.463.263.26
322.371.691.69
380.834.274.27
268.282.052.05
407.892.572.57
393.862.262.26
422.502.422.42
374.412.272.27
335.823.643.64
378.483.453.45
357.422.912.91
400.912.532.53
387.233.273.27
524.544.114.11
459.383.333.33
327.373.553.55
348.363.183.18
602.044.364.36
343.823.143.14
284.343.423.42
213.221.401.40
342.473.533.53
221.693.103.10
294.403.523.52
335.453.223.22
289.772.752.75
303.362.702.70
353.453.143.14
357.852.022.02
336.831.681.68
318.752.782.78
359.393.243.24
342.423.523.52
318.761.801.80
424.033.633.63
429.504.894.89
453.973.293.29
380.851.951.95
353.454.034.03
358.854.054.05
338.413.693.69
350.454.334.33
381.433.523.52
331.401.091.09
346.453.813.81
412.904.564.56
353.453.063.06
354.393.333.33
304.362.992.99
304.362.992.99
458.544.224.22
324.341.971.97
509.473.823.82
392.853.453.45
246.703.303.30
386.763.863.86
379.364.424.42
335.381.721.72
281.222.412.41
416.413.523.52
392.422.922.92
227.272.652.65
228.282.602.60
459.533.533.53
469.372.862.86
350.423.483.48
346.433.583.58
334.372.992.99
350.423.873.87
297.403.113.11
355.442.702.70
355.442.702.70
341.422.272.27
355.442.662.66
337.412.832.83
328.371.821.82
282.311.321.32
295.352.562.56
346.894.044.04
309.422.982.98
328.202.772.77
343.772.712.71
327.433.133.13
319.372.542.54
442.483.423.42
365.523.923.92
449.433.383.38
449.433.383.38
433.433.683.68
453.854.024.02
252.282.162.16
330.393.583.58
305.342.612.61
322.371.941.94
381.484.794.79
351.412.522.52
326.401.901.90
604.613.333.33
588.613.633.63
343.434.024.02
577.634.064.06
326.423.473.47
340.463.653.65
308.434.214.21
349.413.543.54
331.393.613.61
338.243.503.50
518.972.952.95
290.374.054.05
525.023.133.13
400.534.534.53
545.614.784.78
488.012.902.90
488.012.902.90
482.994.724.72
337.403.583.58
311.393.663.66
496.623.613.61
421.242.972.97
318.693.693.69
349.374.174.17
361.404.044.04
608.674.434.43
353.403.413.41
410.954.184.18
501.382.302.30
315.804.494.49
369.403.583.58
355.383.193.19
391.434.054.05
461.494.024.02
496.553.333.33
469.633.473.47
507.032.742.74
489.612.722.72
427.554.424.42
241.042.542.54
720.674.644.64
597.634.414.41
433.313.513.51
292.303.423.42
463.593.463.46
518.895.155.15
554.593.263.26
615.593.323.32
356.843.923.92
391.454.964.96
321.343.893.89
359.393.193.19
517.945.305.30
316.363.643.64
482.344.474.47
498.614.534.53
463.415.315.31
477.395.035.03
442.573.883.88
297.322.072.07
292.252.462.46
471.473.553.55
427.463.823.82
329.342.552.55
270.763.853.85
413.482.952.95
341.371.231.23
425.513.313.31
491.494.374.37
469.612.952.95
475.563.223.22
387.484.014.01
437.293.853.85
369.604.484.48
347.403.903.90
419.664.164.16
345.783.403.40
374.874.224.22
387.484.014.01
490.594.174.17
471.973.883.88
426.944.264.26
480.483.783.78
311.414.024.02
270.383.213.21
393.783.033.03
306.823.723.72
437.842.682.68
324.413.333.33
569.062.072.07
231.301.701.70
301.353.323.32
274.663.913.91
227.022.232.23
304.782.832.83
225.321.851.85
419.534.634.63
546.675.735.73
385.772.712.71
446.534.654.65
322.703.213.21
307.313.183.18
418.523.133.13
292.343.603.60
423.972.792.79
407.973.353.35
280.331.331.33
553.442.992.99
384.693.583.58
222.253.003.00
367.391.581.58
366.412.332.33
413.363.913.91
426.903.343.34
344.332.602.60
352.234.094.09
408.962.152.15
545.134.104.10
425.334.364.36
479.274.254.25
372.474.264.26
454.354.204.20
567.472.562.56
279.552.712.71
465.564.254.25