Drug metabolism in human liver cytosol at 20 uM assessed as (1R,2S,5S)-N-((2S,3R)-4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-yl)-3-((S)-2-(3-tert-but...

ID: ALA3528334

Type: ADME

Description: Drug metabolism in human liver cytosol at 20 uM assessed as (1R,2S,5S)-N-((2S,3R)-4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-yl)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide formation at 20 uM after 60 mins in presence of AKR inhibitor ibuprofen by LC-MS/MS/FSA method

Format: BAO_0000019

Organism: Homo sapiens

Tissue: Liver

Target:  Liver cytosol(ALA2367378)

Document:  ALA3526141

Drug metabolism in human liver cytosol at 20 uM assessed as (1R,2S,5S)-N-((2S,3R)-4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-yl)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide formation at 20 uM after 60 mins in presence of AKR inhibitor ibuprofen by LC-MS/MS/FSA method: 1