Basic Information
ID: ALA3540640
Type: ADME
Description: Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by LC-MS/MS analysis in presence of NADPH
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA3540640
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 414.53 | 3.37 | 3.37 |
| 309.33 | 4.44 | 4.44 |
| 473.59 | 6.08 | 6.08 |
| 733.94 | 1.79 | 1.79 |
| 720.96 | 5.91 | 5.91 |
| 324.42 | 3.17 | 3.17 |
| 372.42 | 3.78 | 3.78 |
| 338.40 | 5.61 | 5.61 |