ID: ALA3540641
Type: ADME
Description: Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by LC-MS/MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Bioactivity
Activity Types for Assay ALA3540641
Inhibition
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
454.61 | 5.09 | 5.09 |
414.53 | 3.37 | 3.37 |
309.33 | 4.44 | 4.44 |
473.59 | 6.08 | 6.08 |
733.94 | 1.79 | 1.79 |
720.96 | 5.91 | 5.91 |
324.42 | 3.17 | 3.17 |
372.42 | 3.78 | 3.78 |
338.40 | 5.61 | 5.61 |