Basic Information
ID: ALA3541093
Type: ADME
Description: Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method
Format: BAO_0000357
Organism: Homo sapiens
Target: Cytochrome P450 2J2(ALA3491)
Document: ALA3526101
Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3541093
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 319.34 | 1.27 | 1.27 |
| 280.42 | 3.88 | 3.88 |
| 267.37 | 1.61 | 1.61 |
| 249.35 | 2.15 | 2.15 |
| 290.32 | 1.26 | 1.26 |
| 454.61 | 5.09 | 5.09 |
| 398.40 | 3.70 | 3.70 |
| 414.53 | 3.37 | 3.37 |
| 341.43 | 0.56 | 0.56 |
| 259.35 | 2.58 | 2.58 |
| 252.35 | 0.60 | 0.60 |
| 297.75 | -0.35 | -0.35 |
| 330.75 | 1.89 | 1.89 |
| 309.33 | 4.44 | 4.44 |
| 326.83 | 3.72 | 3.72 |
| 375.87 | 4.43 | 4.43 |
| 369.37 | 3.52 | 3.52 |
| 318.87 | 4.89 | 4.89 |
| 266.39 | 3.53 | 3.53 |
| 327.38 | 1.30 | 1.30 |
| 309.41 | 3.42 | 3.42 |
| 206.28 | 3.07 | 3.07 |
| 331.35 | 1.58 | 1.58 |
| 733.94 | 1.79 | 1.79 |
| 236.27 | 3.39 | 3.39 |
| 179.26 | 2.03 | 2.03 |
| 151.16 | 1.35 | 1.35 |
| 179.22 | 2.04 | 2.04 |
| 403.98 | 3.94 | 3.94 |
| 254.29 | 3.11 | 3.11 |
| 516.86 | 9.91 | 9.91 |
| 188.23 | 1.48 | 1.48 |
| 341.45 | 3.24 | 3.24 |
| 360.45 | 1.56 | 1.56 |
| 414.35 | 3.44 | 3.44 |
| 255.36 | 3.35 | 3.35 |
| 355.87 | 5.18 | 5.18 |
| 296.15 | 4.36 | 4.36 |
| 241.29 | 3.75 | 3.75 |
| 404.50 | 5.39 | 5.39 |
| 230.26 | 3.04 | 3.04 |
| 306.24 | 5.18 | 5.18 |
| 263.79 | 3.96 | 3.96 |
| 261.37 | 3.42 | 3.42 |
| 218.26 | 1.47 | 1.47 |
| 495.64 | 5.27 | 5.27 |
| 271.40 | 3.38 | 3.38 |
| 501.67 | 5.51 | 5.51 |
| 554.59 | -1.20 | -1.20 |
| 337.38 | 1.64 | 1.64 |
| 366.55 | 4.83 | 4.83 |
| 514.63 | 7.26 | 7.26 |
| 365.41 | 0.02 | 0.02 |
| 314.37 | 2.26 | 2.26 |
| 169.57 | 1.77 | 1.77 |
| 418.45 | 2.97 | 2.97 |
| 392.47 | 1.90 | 1.90 |
| 225.21 | -1.33 | -1.33 |
| 457.48 | 0.19 | 0.19 |
| 362.47 | 1.78 | 1.78 |
| 424.09 | 5.46 | 5.46 |
| 394.44 | 0.62 | 0.62 |
| 479.53 | 3.68 | 3.68 |
| 346.34 | 2.18 | 2.18 |
| 345.42 | 2.90 | 2.90 |
| 382.53 | 3.82 | 3.82 |
| 446.51 | 3.66 | 3.66 |
| 813.98 | 3.62 | 3.62 |
| 314.41 | 1.46 | 1.46 |