Basic Information
ID: ALA3583625
Type: Binding
Description: Negative allosteric modulator activity at wild type human dopamine D2L receptor expressed in FlpIn CHO cell membrane assessed as ERK1/2 phosphorylation measured as equilibrium dissociation constant after 30 mins
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CHO
Target: Dopamine D2 receptor(ALA217)
Document: ALA3580546
Negative allosteric modulator activity at wild type human dopamine D2L receptor expressed in FlpIn CHO cell membrane assessed as ERK1/2 phosphorylation measured as equilibrium dissociation constant after 30 mins: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3583625
pKb
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 426.56 | 4.78 | 4.78 |
| 401.55 | 4.90 | 4.90 |
| 419.54 | 5.04 | 5.04 |
| 436.00 | 5.56 | 5.56 |
| 480.45 | 5.67 | 5.67 |
| 469.55 | 5.92 | 5.92 |
| 415.58 | 5.30 | 5.30 |
| 407.58 | 4.97 | 4.97 |
| 460.62 | 4.68 | 4.68 |
| 499.49 | 5.98 | 5.98 |
| 358.45 | 3.22 | 3.22 |
| 372.47 | 3.61 | 3.61 |
| 386.50 | 4.00 | 4.00 |
| 400.53 | 4.39 | 4.39 |
| 440.59 | 5.12 | 5.12 |
| 427.55 | 5.04 | 5.04 |
| 428.54 | 4.44 | 4.44 |
| 425.58 | 4.62 | 4.62 |
| 440.59 | 4.79 | 4.79 |
| 427.55 | 4.17 | 4.17 |
| 427.55 | 4.17 | 4.17 |
| 376.50 | 3.62 | 3.62 |
| 380.54 | 2.73 | 2.73 |
| 380.54 | 2.73 | 2.73 |