Basic Information
ID: ALA3583645
Type: ADME
Description: Therapeutic index, ratio of toxicity in Sprague-Dawley rat assessed as reduction in fasting plasma glucose level at 3 to 100 mg/kg, po administered for 60 mins measured over first hour prior to OGTT method to antidiabetic activity in Sprague-Dawley rat assessed as reduction of post-prandial glucose AUC excursion at 3 to 100 mg/kg, po administered for 60 mins followed by glucose challenge measured up to 120 mins by OGTT method
Organism: Rattus norvegicus
Strain: Sprague-Dawley
Tissue: Plasma
Activity Charts
Bioactivity
Activity Types for Assay ALA3583645
TI
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 438.55 | 3.76 | 3.76 |
| 349.42 | 3.00 | 3.00 |
| 421.91 | 3.02 | 3.02 |
| 432.44 | 3.38 | 3.38 |
| 432.44 | 3.38 | 3.38 |
| 449.45 | 2.95 | 2.95 |
| 475.48 | 3.58 | 3.58 |
| 450.50 | 3.07 | 3.07 |
| 464.50 | 4.16 | 4.16 |
| 478.51 | 2.88 | 2.88 |
| 460.51 | 2.41 | 2.41 |
| 491.52 | 4.11 | 4.11 |
| 452.47 | 1.64 | 1.64 |
| 463.49 | 2.61 | 2.61 |
| 422.45 | 2.88 | 2.88 |