Basic Information
ID: ALA3603426
Type: Binding
Description: Inhibition of IRAK4-dependent TLR4 signaling in human THP1-XBlue cells containing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of LPS-EK-induced TLR4 activation incubated at 37 degC for 1 hr by spectrophotometry
Format: BAO_0000219
Organism: Homo sapiens
Cell type: THP-1
Target: Interleukin-1 receptor-associated kinase 4(ALA3778)
Document: ALA3600286
Inhibition of IRAK4-dependent TLR4 signaling in human THP1-XBlue cells containing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of LPS-EK-induced TLR4 activation incubated at 37 degC for 1 hr by spectrophotometry: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3603426
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 502.58 | 3.13 | 3.13 |
| 504.62 | 3.54 | 3.54 |
| 490.59 | 3.23 | 3.23 |
| 474.52 | 2.35 | 2.35 |
| 500.56 | 2.89 | 2.89 |
| 472.55 | 2.96 | 2.96 |
| 477.59 | 3.63 | 3.63 |