Basic Information
ID: ALA3603677
Type: Binding
Description: Antagonist activity at endothelin A receptor in Mongolian gerbil spiral modiolar artery assessed as inhibition of ET-1-induced vasoconstriction at 0.1 to 1 uM treated for 2 mins with ET-1 addition for first min of compound treatment followed by compound washout and again ET-1 addition by video microscopic analysis
Organism: Meriones unguiculatus
Tissue: Spiral modiolar artery
Activity Charts
Bioactivity
Activity Types for Assay ALA3603677
Kd
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 328.50 | 5.11 | 5.11 |
| 355.52 | 5.09 | 5.09 |
| 515.86 | ||
| 401.59 | 4.94 | 4.94 |
| 326.48 | 5.02 | 5.02 |
| 370.53 | 4.68 | 4.68 |
| 632.84 | 8.09 | 8.09 |