Basic Information
ID: ALA3606544
Type: Binding
Description: Antagonist activity at P2X7 receptor in human PBMC assessed as inhibition of BzATP-induced IL1beta release incubated 30 mins prior to BzATP-challenge measured after 1.5 hrs by ELISA method
Format: BAO_0000357
Organism: Homo sapiens
Target: P2X purinoceptor 7(ALA4805)
Document: ALA3603800
Antagonist activity at P2X7 receptor in human PBMC assessed as inhibition of BzATP-induced IL1beta release incubated 30 mins prior to BzATP-challenge measured after 1.5 hrs by ELISA method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3606544
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 375.22 | 2.70 | 2.70 |
| 408.77 | 3.06 | 3.06 |
| 424.79 | 4.41 | 4.41 |
| 407.78 | 3.67 | 3.67 |
| 374.23 | 3.30 | 3.30 |
| 388.26 | 3.86 | 3.86 |
| 421.81 | 4.23 | 4.23 |
| 438.81 | 4.97 | 4.97 |
| 405.26 | 4.44 | 4.44 |
| 438.81 | 4.80 | 4.80 |
| 405.26 | 4.61 | 4.61 |
| 438.81 | 4.97 | 4.97 |
| 405.36 | 3.72 | 3.72 |
| 422.80 | 3.62 | 3.62 |
| 387.27 | 4.30 | 4.30 |
| 420.82 | 4.66 | 4.66 |
| 388.26 | 3.86 | 3.86 |
| 388.26 | 3.86 | 3.86 |
| 405.26 | 4.44 | 4.44 |
| 405.26 | 4.44 | 4.44 |
| 438.81 | 4.80 | 4.80 |
| 389.25 | 3.09 | 3.09 |
| 422.80 | 3.45 | 3.45 |
| 388.26 | 3.69 | 3.69 |
| 406.25 | 3.83 | 3.83 |
| 418.28 | 3.70 | 3.70 |
| 406.25 | 3.83 | 3.83 |
| 407.24 | 3.23 | 3.23 |
| 406.25 | 3.83 | 3.83 |