Basic Information
ID: ALA3607229
Type: Binding
Description: Antagonist activity against glucocorticoid receptor in rat H4-IIE cells assessed as inhibition of dexamethasone-induced receptor transactivation pre-incubated for 1 hr before dexamethasone addition and measured 24 hrs post dexamethasone stimulation by tyrosine aminotransferase enzyme assay
Format: BAO_0000219
Organism: Rattus norvegicus
Cell type: H4-IIE
Target: Glucocorticoid receptor(ALA3368)
Document: ALA3603837
Antagonist activity against glucocorticoid receptor in rat H4-IIE cells assessed as inhibition of dexamethasone-induced receptor transactivation pre-incubated for 1 hr before dexamethasone addition and measured 24 hrs post dexamethasone stimulation by tyrosine aminotransferase enzyme assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3607229
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 429.60 | 5.41 | 5.41 |
| 509.65 | 6.11 | 6.11 |
| 523.67 | 6.28 | 6.28 |
| 466.58 | 6.07 | 6.07 |
| 366.39 | 3.80 | 3.80 |
| 350.83 | 3.87 | 3.87 |
| 320.80 | 3.86 | 3.86 |
| 316.38 | 3.22 | 3.22 |