Basic Information
ID: ALA3611617
Type: Binding
Description: Antagonist activity at Kv1.3 in human whole blood assessed as inhibition of thapsigargin-induced IFN-gamma secretion incubated for 30 prior to thapsigargin induction measured after 48 hrs by electrochemilluminescent immunoassay
Format: BAO_0000357
Organism: Homo sapiens
Tissue: Blood
Target: Voltage-gated potassium channel subunit Kv1.3(ALA4633)
Document: ALA3608278
Antagonist activity at Kv1.3 in human whole blood assessed as inhibition of thapsigargin-induced IFN-gamma secretion incubated for 30 prior to thapsigargin induction measured after 48 hrs by electrochemilluminescent immunoassay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3611617
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 4123.91 | ||
| 3969.74 | ||
| 4038.85 | ||
| 4012.77 | ||
| 4024.82 | ||
| 4012.77 | ||
| 4028.81 | ||
| 3997.75 | ||
| 4038.85 | ||
| 4195.03 | ||
| 4046.82 | ||
| 4096.89 | ||
| 4052.76 | ||
| 4055.79 | ||
| 4020.79 | ||
| 4027.78 | ||
| 4070.80 | ||
| 4096.89 | ||
| 4036.79 | ||
| 4027.78 | ||
| 4055.79 | ||
| 4082.86 | ||
| 4126.91 | ||
| 4082.86 | ||
| 4123.96 | ||
| 4097.88 | ||
| 4095.95 | ||
| 4107.96 | ||
| 4097.88 | ||
| 4113.92 | ||
| 4082.86 | ||
| 4123.96 | ||
| 4109.93 | ||
| 4222.11 | ||
| 3997.80 | ||
| 4082.91 | ||
| 4082.86 | ||
| 4073.90 | ||
| 4123.96 | ||
| 4079.84 | ||
| 4082.86 | ||
| 3969.74 | ||
| 4024.82 | ||
| 3978.75 | ||
| 3997.80 | ||
| 3997.75 | ||
| 3988.79 | ||
| 4038.85 | ||
| 3994.73 | ||
| 3997.75 | ||
| 3962.75 | ||
| 3969.74 | ||
| 4012.77 | ||
| 4038.85 | ||
| 3978.75 | ||
| 3969.74 | ||
| 3997.75 | ||
| 4024.82 | ||
| 4068.88 | ||
| 4024.82 | ||
| 4095.90 | ||
| 4165.01 | ||
| 4138.93 | ||
| 4137.00 | ||
| 4149.01 | ||
| 4138.93 | ||
| 4123.91 | ||
| 4165.01 | ||
| 4095.90 | ||
| 4150.98 | ||
| 4263.16 | ||
| 4038.85 | ||
| 4123.96 | ||
| 4114.94 | ||
| 4165.01 | ||
| 4120.89 | ||
| 4123.91 | ||
| 4088.91 | ||
| 4138.93 | ||
| 4165.01 | ||
| 4104.91 | ||
| 4095.90 | ||
| 4123.91 | ||
| 4150.98 | ||
| 4195.03 | ||
| 4150.98 | ||
| 4027.78 | ||
| 4096.89 | ||
| 4070.80 | ||
| 4068.88 | ||
| 4080.89 | ||
| 4070.80 | ||
| 4086.85 | ||
| 4055.79 | ||
| 4096.89 | ||
| 4027.78 | ||
| 4082.86 | ||
| 4055.83 | ||
| 4055.79 | ||
| 3970.72 |