Inhibition of DNA gyrase GyrA/GyrB in Mycobacterium tuberculosis incubated for 30 mins assessed as reduction in supercoiling of relaxed relaxed pBR322...

Basic Information

ID: ALA3630322

Type: Binding

Description: Inhibition of DNA gyrase GyrA/GyrB in Mycobacterium tuberculosis incubated for 30 mins assessed as reduction in supercoiling of relaxed relaxed pBR322 DNA by ethidium bromide staining based agarose gel electrophoresis method

Format: BAO_0000019

Organism: Mycobacterium tuberculosis

Target: DNA gyrase subunit A/DNA gyrase subunit B(ALA3430898)

Document: ALA3627613

Inhibition of DNA gyrase GyrA/GyrB in Mycobacterium tuberculosis incubated for 30 mins assessed as reduction in supercoiling of relaxed relaxed pBR322 DNA by ethidium bromide staining based agarose gel electrophoresis method: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA3630322

IC50

Total(50)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
401.44	2.37	2.37
137.14	-0.31	-0.31
612.63	3.63	3.63
822.95	4.34	4.34
435.52	4.26	4.26
465.55	4.26	4.26
453.51	4.40	4.40
503.52	5.28	5.28
434.54	4.29	4.29
464.57	4.30	4.30
452.53	4.43	4.43
502.54	5.31	5.31
462.59	4.56	4.56
492.62	4.57	4.57
480.58	4.70	4.70
530.59	5.58	5.58
461.61	4.59	4.59
491.64	4.60	4.60
479.60	4.73	4.73
529.61	5.61	5.61
421.50	2.68	2.68
451.53	2.69	2.69
439.49	2.82	2.82
489.50	3.70	3.70
420.52	2.72	2.72
450.54	2.72	2.72
438.51	2.86	2.86
488.51	3.73	3.73
448.57	2.99	2.99
478.60	3.00	3.00
466.56	3.13	3.13
516.57	4.01	4.01
447.59	3.02	3.02
477.61	3.03	3.03
465.58	3.16	3.16
515.58	4.04	4.04
407.47	3.78	3.78
437.50	3.79	3.79
425.46	3.92	3.92
475.47	4.80	4.80
406.49	3.81	3.81
436.51	3.82	3.82
424.48	3.95	3.95
474.48	4.83	4.83
434.54	4.08	4.08
464.57	4.09	4.09
452.53	4.22	4.22
502.54	5.10	5.10
433.56	4.12	4.12
463.58	4.12	4.12