Basic Information
ID: ALA3635808
Type: Functional
Description: In vivo inhibition of EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells xenografted in athymic nude mouse at 30 mg/kg, po measured at 4 hrs by mesoscale multiplex assay relative to control
Organism: Mus musculus
Cell type: NCI-H1975
Activity Charts
Bioactivity
Activity Types for Assay ALA3635808
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 499.62 | 4.51 | 4.51 |
| 525.61 | 3.72 | 3.72 |
| 495.59 | 3.71 | 3.71 |
| 553.62 | 3.63 | 3.63 |
| 511.59 | 3.38 | 3.38 |
| 524.63 | 4.78 | 4.78 |
| 512.57 | 3.80 | 3.80 |
| 527.63 | 3.96 | 3.96 |
| 514.59 | 3.91 | 3.91 |