Basic Information
ID: ALA3705045
Type: Binding
Description: Time-Resolved FRET Assay: A homogeneous time-resolved FRET assay was used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. The assay monitored the increase of 620nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7-EISEVNLDAEFC-Europium-amide).
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705045
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 420.40 | 1.33 | 1.33 |
| 398.44 | 1.44 | 1.44 |
| 382.44 | 1.60 | 1.60 |
| 398.44 | 1.31 | 1.31 |
| 410.91 | 2.43 | 2.43 |
| 438.39 | 1.47 | 1.47 |
| 436.39 | 1.03 | 1.03 |
| 436.39 | 1.03 | 1.03 |
| 420.40 | 1.33 | 1.33 |
| 384.42 | 1.05 | 1.05 |
| 438.39 | 1.47 | 1.47 |
| 419.46 | 1.79 | 1.79 |
| 402.41 | 1.19 | 1.19 |
| 402.41 | 1.19 | 1.19 |
| 418.86 | 1.70 | 1.70 |
| 462.89 | 2.41 | 2.41 |
| 436.85 | 1.84 | 1.84 |
| 428.44 | 1.76 | 1.76 |
| 452.41 | 1.72 | 1.72 |
| 368.42 | 1.35 | 1.35 |
| 414.44 | 1.14 | 1.14 |
| 394.45 | 1.92 | 1.92 |
| 424.94 | 2.69 | 2.69 |
| 418.40 | 0.89 | 0.89 |
| 386.41 | 1.49 | 1.49 |
| 456.38 | 1.61 | 1.61 |
| 416.43 | 1.44 | 1.44 |
| 434.42 | 1.58 | 1.58 |
| 434.42 | 1.58 | 1.58 |
| 418.86 | 1.70 | 1.70 |
| 446.43 | 1.90 | 1.90 |
| 462.89 | 2.41 | 2.41 |
| 409.43 | 0.92 | 0.92 |
| 430.43 | 2.20 | 2.20 |
| 446.43 | 1.90 | 1.90 |
| 454.84 | 1.98 | 1.98 |
| 438.39 | 1.47 | 1.47 |
| 474.37 | 2.04 | 2.04 |
| 470.40 | 2.13 | 2.13 |
| 436.39 | 0.51 | 0.51 |
| 420.40 | 1.54 | 1.54 |
| 436.85 | 2.05 | 2.05 |
| 436.85 | 2.05 | 2.05 |