Basic Information
ID: ALA3705063
Type: Binding
Description: Cellular Assay: ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways may be activated by ionising radiation, however only ATR is activated by UV. Since UV treatment is not practical for use in a high throught-put cell assay, the UV mimetic 4NQ0 (Sigma) was chosen to activate the ATR DNA damage response pathway.
Format: BAO_0000357
Organism: Homo sapiens
Target: Serine-protein kinase ATR(ALA5024)
Document: ALA3638805
BindingDB Source: 5982
Activity Charts
Bioactivity
Activity Types for Assay ALA3705063
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 386.48 | 1.18 | 1.18 |
| 412.52 | 2.91 | 2.91 |
| 441.56 | 2.75 | 2.75 |
| 411.53 | 2.43 | 2.43 |
| 427.53 | 1.20 | 1.20 |
| 459.55 | 1.80 | 1.80 |
| 412.52 | 1.82 | 1.82 |
| 443.58 | 1.91 | 1.91 |
| 485.61 | 1.68 | 1.68 |
| 455.58 | 2.45 | 2.45 |
| 461.57 | 2.05 | 2.05 |
| 461.57 | 2.05 | 2.05 |
| 459.55 | 1.80 | 1.80 |
| 461.57 | 2.05 | 2.05 |
| 459.55 | 1.80 | 1.80 |
| 412.52 | 2.91 | 2.91 |