Basic Information
ID: ALA3705106
Type: Binding
Description: PIM-1 Enzyme Assay: The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled peptide onto a Whatman P81 (phosphocellulose) filter plate. Assay mixtures contained 35uM [gamma-33P] ATP (20 uCi/mL), 7.5 uM PIM2tide and 0.25 nM PIM-1 in a total volume of 50 pt.
Format: BAO_0000357
Target: Serine/threonine-protein kinase PIM1(ALA2147)
Document: ALA3639321
BindingDB Source: 6019
Activity Charts
Bioactivity
Activity Types for Assay ALA3705106
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 344.42 | 3.11 | 3.11 |
| 400.53 | 4.67 | 4.67 |
| 359.43 | 3.66 | 3.66 |
| 330.40 | 2.72 | 2.72 |
| 330.40 | 2.72 | 2.72 |
| 418.50 | 4.27 | 4.27 |
| 318.38 | 2.71 | 2.71 |
| 388.52 | 4.15 | 4.15 |
| 345.41 | 3.08 | 3.08 |
| 319.37 | 2.67 | 2.67 |
| 331.38 | 2.69 | 2.69 |
| 331.38 | 2.69 | 2.69 |
| 359.43 | 3.32 | 3.32 |
| 373.46 | 3.86 | 3.86 |
| 359.43 | 3.32 | 3.32 |
| 359.43 | 3.59 | 3.59 |
| 347.42 | 3.31 | 3.31 |
| 377.45 | 2.80 | 2.80 |
| 347.42 | 3.44 | 3.44 |
| 375.48 | 3.91 | 3.91 |
| 346.39 | 3.10 | 3.10 |
| 332.41 | 4.37 | 4.37 |
| 348.41 | 3.34 | 3.34 |
| 363.40 | 3.02 | 3.02 |
| 363.40 | 3.02 | 3.02 |
| 375.48 | 3.96 | 3.96 |
| 361.45 | 3.57 | 3.57 |
| 371.44 | 3.61 | 3.61 |
| 375.48 | 4.09 | 4.09 |
| 375.48 | 4.09 | 4.09 |
| 361.45 | 3.70 | 3.70 |
| 361.45 | 3.70 | 3.70 |
| 389.50 | 4.48 | 4.48 |
| 389.50 | 4.48 | 4.48 |
| 365.41 | 3.45 | 3.45 |
| 388.43 | 2.87 | 2.87 |
| 355.35 | 2.92 | 2.92 |
| 365.41 | 3.45 | 3.45 |
| 353.39 | 3.92 | 3.92 |
| 353.39 | 3.92 | 3.92 |
| 377.42 | 3.41 | 3.41 |
| 377.42 | 3.41 | 3.41 |
| 359.43 | 3.47 | 3.47 |
| 416.49 | 2.53 | 2.53 |
| 432.48 | 2.46 | 2.46 |
| 375.43 | 2.44 | 2.44 |
| 389.46 | 3.09 | 3.09 |
| 426.32 | 4.07 | 4.07 |
| 381.39 | 3.16 | 3.16 |
| 381.39 | 3.16 | 3.16 |
| 345.41 | 3.08 | 3.08 |
| 336.35 | 1.68 | 1.68 |
| 426.32 | 4.07 | 4.07 |
| 387.49 | 4.19 | 4.19 |
| 423.52 | 4.98 | 4.98 |
| 373.46 | 3.71 | 3.71 |
| 387.49 | 4.10 | 4.10 |
| 413.53 | 4.49 | 4.49 |
| 401.51 | 4.35 | 4.35 |
| 465.56 | 4.35 | 4.35 |
| 375.43 | 2.44 | 2.44 |
| 389.46 | 3.09 | 3.09 |
| 339.36 | 4.13 | 4.13 |
| 354.37 | 3.71 | 3.71 |
| 355.36 | 3.11 | 3.11 |
| 456.32 | 4.18 | 4.18 |
| 442.29 | 3.79 | 3.79 |
| 417.49 | 4.29 | 4.29 |
| 403.46 | 3.90 | 3.90 |
| 453.52 | 5.08 | 5.08 |
| 439.49 | 4.69 | 4.69 |
| 434.48 | 2.61 | 2.61 |
| 391.45 | 3.76 | 3.76 |
| 421.48 | 3.12 | 3.12 |
| 417.51 | 3.42 | 3.42 |
| 389.42 | 2.23 | 2.23 |
| 381.39 | 3.16 | 3.16 |
| 395.41 | 3.55 | 3.55 |
| 391.45 | 3.72 | 3.72 |
| 399.38 | 3.46 | 3.46 |
| 363.40 | 3.02 | 3.02 |
| 417.49 | 4.29 | 4.29 |
| 391.45 | 3.72 | 3.72 |
| 402.43 | 3.96 | 3.96 |
| 395.41 | 3.55 | 3.55 |
| 395.41 | 3.55 | 3.55 |
| 405.48 | 4.15 | 4.15 |
| 423.47 | 4.10 | 4.10 |
| 395.41 | 3.55 | 3.55 |
| 349.37 | 2.63 | 2.63 |
| 367.36 | 2.77 | 2.77 |
| 407.45 | 3.42 | 3.42 |
| 425.44 | 3.56 | 3.56 |
| 451.50 | 3.44 | 3.44 |
| 396.42 | 2.84 | 2.84 |
| 378.43 | 2.70 | 2.70 |
| 421.48 | 3.62 | 3.62 |
| 465.53 | 3.33 | 3.33 |
| 389.46 | 2.83 | 2.83 |
| 377.42 | 3.42 | 3.42 |