Basic Information
ID: ALA3705117
Type: Binding
Description: Biological Assay Example 8: Using a procedure similar to that described in Biological Test Example 6, the inhibition of cytochrome P450 2C19-isoenzyme catalysed N-demethylation of [N-methyl-14C]-Diazepam by the test compound was assayed at 37° C. with human recombinant cytochrome P450 2C19.
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705117
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 455.56 | 5.78 | 5.78 |
| 478.56 | 5.15 | 5.15 |
| 446.55 | 4.62 | 4.62 |
| 469.59 | 5.79 | 5.79 |
| 469.59 | 5.79 | 5.79 |
| 488.63 | 5.89 | 5.89 |
| 474.60 | 5.50 | 5.50 |
| 474.60 | 5.40 | 5.40 |
| 474.60 | 5.40 | 5.40 |
| 430.55 | 5.65 | 5.65 |
| 474.60 | 5.32 | 5.32 |
| 492.59 | 5.63 | 5.63 |
| 474.60 | 5.32 | 5.32 |
| 474.60 | 5.50 | 5.50 |
| 528.57 | 6.04 | 6.04 |
| 528.57 | 6.04 | 6.04 |
| 488.63 | 6.06 | 6.06 |
| 487.58 | 5.93 | 5.93 |
| 488.63 | 5.80 | 5.80 |
| 488.63 | 5.80 | 5.80 |
| 486.61 | 5.81 | 5.81 |
| 500.64 | 5.89 | 5.89 |
| 432.52 | 4.50 | 4.50 |
| 432.52 | 4.50 | 4.50 |
| 478.56 | 5.15 | 5.15 |
| 518.65 | 5.25 | 5.25 |
| 532.68 | 5.76 | 5.76 |
| 518.65 | 5.10 | 5.10 |
| 532.68 | 5.90 | 5.90 |
| 504.60 | 5.95 | 5.95 |
| 486.61 | 5.81 | 5.81 |
| 496.55 | 5.87 | 5.87 |
| 496.55 | 5.87 | 5.87 |
| 478.56 | 5.15 | 5.15 |
| 492.59 | 5.44 | 5.44 |
| 446.55 | 4.62 | 4.62 |
| 478.56 | 5.15 | 5.15 |
| 464.54 | 4.76 | 4.76 |
| 460.57 | 5.01 | 5.01 |
| 460.57 | 5.01 | 5.01 |
| 488.63 | 6.06 | 6.06 |
| 454.57 | 5.89 | 5.89 |