Basic Information
ID: ALA3705121
Type: Binding
Description: Biological Assay Example 1: The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly, S. S. Mundt, H. J. Zokian, G. J. Ding, A. Hermanowski-Vosatka, B. Strulovici, and W. Zheng, High-Throughput Screening of 11-Beta-Hydroxyseroid Dehydrogenase Type 1 in Scintillation Proximity Assay Format. Assay Drug Dev Technol 3 (2005) 377-384).
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705121
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 451.51 | 6.20 | 6.20 |
| 433.52 | 6.06 | 6.06 |
| 455.48 | 5.95 | 5.95 |
| 437.49 | 5.81 | 5.81 |
| 482.50 | 5.84 | 5.84 |
| 546.61 | 5.90 | 5.90 |
| 409.43 | 5.26 | 5.26 |
| 428.41 | 4.79 | 4.79 |
| 392.43 | 4.51 | 4.51 |
| 483.53 | 6.73 | 6.73 |
| 446.52 | 5.56 | 5.56 |
| 447.55 | 6.45 | 6.45 |
| 450.35 | 5.55 | 5.55 |
| 409.40 | 4.61 | 4.61 |
| 432.36 | 5.41 | 5.41 |
| 446.55 | 5.00 | 5.00 |
| 446.55 | 5.00 | 5.00 |
| 459.59 | 4.98 | 4.98 |
| 501.63 | 5.16 | 5.16 |
| 517.63 | 5.38 | 5.38 |
| 523.66 | 4.56 | 4.56 |
| 537.68 | 4.57 | 4.57 |
| 551.71 | 4.91 | 4.91 |
| 455.56 | 5.78 | 5.78 |
| 473.55 | 5.92 | 5.92 |
| 478.56 | 5.15 | 5.15 |
| 478.56 | 5.15 | 5.15 |
| 478.56 | 5.15 | 5.15 |
| 450.51 | 4.37 | 4.37 |
| 459.55 | 4.12 | 4.12 |
| 523.66 | 4.18 | 4.18 |
| 446.55 | 4.62 | 4.62 |
| 450.51 | 4.75 | 4.75 |
| 460.57 | 5.11 | 5.11 |
| 460.57 | 5.01 | 5.01 |
| 432.52 | 4.61 | 4.61 |
| 446.55 | 4.62 | 4.62 |
| 469.59 | 5.79 | 5.79 |
| 469.59 | 5.79 | 5.79 |
| 487.60 | 4.75 | 4.75 |
| 474.60 | 5.50 | 5.50 |
| 474.60 | 5.40 | 5.40 |
| 474.60 | 5.40 | 5.40 |
| 430.55 | 5.65 | 5.65 |
| 444.58 | 6.13 | 6.13 |
| 430.55 | 5.65 | 5.65 |
| 458.60 | 6.70 | 6.70 |
| 474.60 | 5.32 | 5.32 |
| 492.59 | 5.63 | 5.63 |
| 416.52 | 5.26 | 5.26 |
| 474.60 | 5.32 | 5.32 |
| 474.60 | 5.50 | 5.50 |
| 528.57 | 6.04 | 6.04 |
| 528.57 | 6.04 | 6.04 |
| 488.63 | 6.06 | 6.06 |
| 487.58 | 5.93 | 5.93 |
| 488.63 | 5.80 | 5.80 |
| 488.63 | 5.80 | 5.80 |
| 488.63 | 5.63 | 5.63 |
| 486.61 | 5.81 | 5.81 |
| 490.60 | 4.47 | 4.47 |
| 504.60 | 5.95 | 5.95 |
| 494.63 | 5.08 | 5.08 |
| 464.61 | 5.45 | 5.45 |
| 480.65 | 6.09 | 6.09 |
| 500.59 | 5.70 | 5.70 |
| 486.61 | 5.81 | 5.81 |
| 496.55 | 5.87 | 5.87 |
| 496.55 | 5.87 | 5.87 |
| 487.60 | 4.75 | 4.75 |
| 537.68 | 4.57 | 4.57 |
| 487.58 | 5.93 | 5.93 |
| 426.56 | 4.51 | 4.51 |
| 424.54 | 4.27 | 4.27 |
| 498.58 | 5.18 | 5.18 |
| 490.60 | 4.47 | 4.47 |
| 476.57 | 3.98 | 3.98 |
| 490.60 | 4.64 | 4.64 |
| 478.56 | 5.15 | 5.15 |
| 492.59 | 5.44 | 5.44 |
| 412.53 | 4.12 | 4.12 |
| 432.52 | 4.61 | 4.61 |
| 446.55 | 4.62 | 4.62 |
| 478.56 | 5.15 | 5.15 |
| 464.54 | 4.76 | 4.76 |
| 445.52 | 4.11 | 4.11 |
| 418.49 | 4.22 | 4.22 |
| 460.57 | 5.01 | 5.01 |
| 446.55 | 4.62 | 4.62 |
| 460.57 | 5.01 | 5.01 |
| 488.63 | 6.06 | 6.06 |
| 454.57 | 5.89 | 5.89 |
| 496.65 | 6.94 | 6.94 |
| 440.58 | 4.90 | 4.90 |
| 452.60 | 5.31 | 5.31 |
| 488.63 | 5.89 | 5.89 |
| 516.68 | 6.52 | 6.52 |
| 541.65 | 4.32 | 4.32 |