Basic Information
ID: ALA3705125
Type: Binding
Description: Kinase Assay: The activity of the compounds according to the invention on the kinase PDK1 which inhibits the signal transduction pathway is determined in an in vitro kinase assay with recombinantly prepared protein.
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705125
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 518.48 | 3.24 | 3.24 |
| 504.45 | 2.85 | 2.85 |
| 532.51 | 3.63 | 3.63 |
| 460.44 | 2.34 | 2.34 |
| 515.52 | 2.02 | 2.02 |
| 564.60 | 3.97 | 3.97 |
| 474.47 | 2.36 | 2.36 |
| 550.57 | 3.93 | 3.93 |
| 540.53 | 3.54 | 3.54 |
| 551.56 | 3.34 | 3.34 |
| 610.62 | 3.97 | 3.97 |
| 515.52 | 1.70 | 1.70 |
| 517.54 | 2.27 | 2.27 |
| 554.56 | 2.99 | 2.99 |
| 556.60 | 4.01 | 4.01 |
| 566.57 | 3.44 | 3.44 |
| 518.52 | 2.74 | 2.74 |
| 564.60 | 4.51 | 4.51 |
| 564.55 | 3.59 | 3.59 |
| 593.59 | 2.80 | 2.80 |
| 580.60 | 3.96 | 3.96 |
| 516.55 | 3.53 | 3.53 |
| 500.51 | 2.89 | 2.89 |
| 530.54 | 2.89 | 2.89 |
| 542.59 | 4.06 | 4.06 |
| 619.68 | 4.37 | 4.37 |
| 573.60 | 2.16 | 2.16 |
| 557.61 | 3.05 | 3.05 |
| 429.51 | 2.72 | 2.72 |
| 499.52 | 3.50 | 3.50 |
| 530.58 | 2.95 | 2.95 |
| 542.59 | 3.04 | 3.04 |
| 556.57 | 2.61 | 2.61 |
| 515.52 | 2.47 | 2.47 |
| 531.56 | 3.33 | 3.33 |
| 516.51 | 2.19 | 2.19 |
| 517.54 | 2.72 | 2.72 |
| 502.48 | 1.80 | 1.80 |
| 529.55 | 3.35 | 3.35 |
| 519.51 | 1.66 | 1.66 |
| 542.59 | 3.26 | 3.26 |
| 556.62 | 3.80 | 3.80 |
| 556.62 | 3.43 | 3.43 |
| 543.57 | 3.25 | 3.25 |
| 427.47 | 1.41 | 1.41 |
| 536.97 | 3.79 | 3.79 |
| 633.63 | 4.86 | 4.86 |
| 579.61 | 4.54 | 4.54 |
| 600.63 | 5.08 | 5.08 |
| 570.64 | 3.68 | 3.68 |
| 536.54 | 4.06 | 4.06 |
| 548.59 | 2.85 | 2.85 |
| 530.54 | 2.40 | 2.40 |
| 413.44 | 2.26 | 2.26 |
| 579.61 | 4.54 | 4.54 |
| 442.45 | 2.20 | 2.20 |
| 515.56 | 4.31 | 4.31 |
| 479.58 | 4.03 | 4.03 |
| 495.58 | 3.00 | 3.00 |
| 546.58 | 2.31 | 2.31 |
| 494.89 | 2.99 | 2.99 |
| 490.47 | 2.34 | 2.34 |
| 473.48 | 3.50 | 3.50 |
| 476.44 | 2.27 | 2.27 |
| 490.47 | 2.29 | 2.29 |
| 453.50 | 2.20 | 2.20 |
| 497.47 | 2.68 | 2.68 |
| 507.50 | 3.96 | 3.96 |
| 445.43 | 2.60 | 2.60 |
| 512.52 | 2.67 | 2.67 |
| 558.59 | 2.58 | 2.58 |
| 529.55 | 3.38 | 3.38 |
| 487.47 | 2.26 | 2.26 |
| 513.50 | 2.79 | 2.79 |
| 570.60 | 2.72 | 2.72 |
| 501.49 | 2.65 | 2.65 |
| 515.52 | 3.04 | 3.04 |
| 570.60 | 2.68 | 2.68 |
| 572.62 | 2.92 | 2.92 |
| 570.60 | 2.72 | 2.72 |
| 542.55 | 1.94 | 1.94 |
| 543.53 | 2.37 | 2.37 |
| 542.55 | 1.94 | 1.94 |
| 556.57 | 2.29 | 2.29 |
| 600.63 | 2.30 | 2.30 |
| 501.49 | 2.60 | 2.60 |
| 556.57 | 2.33 | 2.33 |
| 495.49 | 3.89 | 3.89 |
| 496.48 | 3.29 | 3.29 |
| 511.53 | 3.28 | 3.28 |
| 511.53 | 3.28 | 3.28 |
| 444.44 | 3.21 | 3.21 |
| 510.50 | 3.60 | 3.60 |
| 497.51 | 3.44 | 3.44 |
| 565.62 | 5.15 | 5.15 |
| 573.60 | 5.03 | 5.03 |
| 565.62 | 5.37 | 5.37 |
| 573.60 | 5.01 | 5.01 |
| 579.65 | 5.39 | 5.39 |
| 525.56 | 4.22 | 4.22 |
| 525.56 | 4.22 | 4.22 |
| 559.58 | 4.99 | 4.99 |
| 511.53 | 3.83 | 3.83 |
| 511.53 | 4.20 | 4.20 |
| 483.48 | 3.42 | 3.42 |
| 587.63 | 5.06 | 5.06 |
| 573.60 | 2.16 | 2.16 |
| 473.48 | 3.25 | 3.25 |
| 545.59 | 2.97 | 2.97 |
| 461.43 | 2.30 | 2.30 |
| 476.49 | 2.59 | 2.59 |
| 531.57 | 2.29 | 2.29 |
| 532.55 | 2.63 | 2.63 |
| 480.86 | 2.53 | 2.53 |
| 447.40 | 2.00 | 2.00 |
| 517.54 | 2.27 | 2.27 |
| 545.59 | 2.68 | 2.68 |
| 460.44 | 2.34 | 2.34 |
| 474.47 | 2.36 | 2.36 |
| 529.55 | 2.41 | 2.41 |
| 532.55 | 2.62 | 2.62 |
| 534.59 | 2.95 | 2.95 |
| 543.58 | 2.80 | 2.80 |
| 543.58 | 2.80 | 2.80 |
| 557.61 | 3.19 | 3.19 |
| 569.62 | 3.33 | 3.33 |
| 529.55 | 2.05 | 2.05 |
| 559.62 | 3.29 | 3.29 |
| 528.56 | 4.04 | 4.04 |
| 529.55 | 2.46 | 2.46 |
| 557.61 | 2.82 | 2.82 |
| 569.62 | 3.33 | 3.33 |
| 556.62 | 3.97 | 3.97 |
| 542.59 | 3.41 | 3.41 |
| 536.64 | 2.66 | 2.66 |
| 543.58 | 2.98 | 2.98 |
| 543.58 | 2.98 | 2.98 |
| 488.50 | 3.11 | 3.11 |
| 544.57 | 1.87 | 1.87 |
| 587.63 | 2.82 | 2.82 |
| 544.56 | 2.77 | 2.77 |
| 544.56 | 3.01 | 3.01 |
| 613.67 | 3.35 | 3.35 |
| 572.62 | 2.94 | 2.94 |
| 666.78 | 4.05 | 4.05 |
| 571.63 | 3.58 | 3.58 |
| 529.55 | 2.59 | 2.59 |
| 575.60 | 3.14 | 3.14 |
| 556.62 | 3.80 | 3.80 |
| 575.60 | 3.14 | 3.14 |
| 616.67 | 2.96 | 2.96 |
| 586.64 | 3.42 | 3.42 |
| 586.64 | 3.33 | 3.33 |
| 571.63 | 3.75 | 3.75 |
| 600.67 | 3.98 | 3.98 |
| 587.63 | 2.82 | 2.82 |
| 585.62 | 2.57 | 2.57 |
| 598.68 | 2.82 | 2.82 |
| 585.62 | 2.57 | 2.57 |
| 584.63 | 3.17 | 3.17 |
| 598.65 | 3.74 | 3.74 |
| 606.73 | 3.21 | 3.21 |
| 613.67 | 3.35 | 3.35 |
| 677.83 | 4.04 | 4.04 |
| 666.78 | 4.05 | 4.05 |
| 596.66 | 2.57 | 2.57 |
| 624.72 | 3.35 | 3.35 |
| 659.84 | 3.91 | 3.91 |
| 528.56 | 2.84 | 2.84 |
| 542.59 | 3.18 | 3.18 |
| 485.49 | 3.72 | 3.72 |
| 542.59 | 3.41 | 3.41 |
| 556.62 | 3.80 | 3.80 |
| 555.63 | 4.40 | 4.40 |
| 586.64 | 3.42 | 3.42 |
| 585.66 | 4.03 | 4.03 |
| 569.66 | 4.96 | 4.96 |
| 567.67 | 3.80 | 3.80 |
| 615.68 | 3.56 | 3.56 |
| 599.68 | 4.59 | 4.59 |
| 520.54 | 4.87 | 4.87 |
| 430.41 | 2.90 | 2.90 |
| 506.51 | 4.57 | 4.57 |
| 502.48 | 2.99 | 2.99 |
| 488.45 | 2.91 | 2.91 |
| 501.49 | 2.57 | 2.57 |
| 515.52 | 2.91 | 2.91 |
| 446.41 | 2.61 | 2.61 |
| 529.55 | 3.03 | 3.03 |
| 531.56 | 3.23 | 3.23 |
| 544.61 | 3.29 | 3.29 |
| 473.48 | 2.97 | 2.97 |
| 460.44 | 2.91 | 2.91 |
| 459.45 | 3.51 | 3.51 |
| 530.58 | 3.84 | 3.84 |
| 473.48 | 3.90 | 3.90 |
| 474.47 | 3.30 | 3.30 |
| 487.51 | 4.29 | 4.29 |
| 488.49 | 3.69 | 3.69 |
| 516.55 | 3.44 | 3.44 |
| 517.54 | 2.84 | 2.84 |
| 586.64 | 2.92 | 2.92 |
| 556.61 | 4.23 | 4.23 |
| 559.62 | 3.87 | 3.87 |
| 558.63 | 4.47 | 4.47 |
| 547.56 | 2.20 | 2.20 |
| 546.57 | 2.81 | 2.81 |
| 529.55 | 2.98 | 2.98 |
| 528.56 | 3.59 | 3.59 |
| 544.56 | 3.85 | 3.85 |
| 543.57 | 4.45 | 4.45 |
| 531.56 | 4.31 | 4.31 |
| 543.57 | 3.37 | 3.37 |
| 542.59 | 3.98 | 3.98 |
| 529.55 | 3.03 | 3.03 |
| 528.56 | 3.64 | 3.64 |
| 485.49 | 3.47 | 3.47 |
| 484.51 | 4.08 | 4.08 |
| 516.55 | 2.87 | 2.87 |
| 515.56 | 3.48 | 3.48 |
| 530.58 | 3.26 | 3.26 |
| 529.59 | 3.87 | 3.87 |
| 530.53 | 3.46 | 3.46 |
| 529.55 | 2.89 | 2.89 |
| 543.57 | 3.28 | 3.28 |
| 544.60 | 4.40 | 4.40 |
| 560.60 | 3.37 | 3.37 |
| 574.60 | 4.54 | 4.54 |
| 548.57 | 3.97 | 3.97 |
| 545.59 | 3.62 | 3.62 |
| 559.57 | 3.45 | 3.45 |
| 531.56 | 3.23 | 3.23 |
| 544.56 | 3.70 | 3.70 |
| 516.55 | 3.62 | 3.62 |
| 543.57 | 4.31 | 4.31 |
| 560.58 | 3.97 | 3.97 |
| 556.61 | 4.40 | 4.40 |
| 574.60 | 4.54 | 4.54 |
| 560.58 | 3.97 | 3.97 |
| 559.62 | 4.01 | 4.01 |
| 545.59 | 4.46 | 4.46 |
| 503.51 | 3.44 | 3.44 |
| 573.60 | 3.84 | 3.84 |
| 574.60 | 4.36 | 4.36 |
| 588.63 | 4.93 | 4.93 |
| 673.74 | 4.07 | 4.07 |
| 687.76 | 4.63 | 4.63 |
| 604.63 | 3.90 | 3.90 |
| 584.67 | 5.00 | 5.00 |
| 542.59 | 3.88 | 3.88 |
| 475.46 | 2.69 | 2.69 |
| 502.48 | 2.00 | 2.00 |
| 488.45 | 1.65 | 1.65 |