Basic Information
ID: ALA3705129
Type: Binding
Description: In Vitro Inhibition Assay: In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF is hydroxylated on a conserved prolyl radical. It is the basis for the biochemical determination of HIF prolyl hydroxylase activity. The test is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. Biochem. 330 (1), 74-80 (2004)].
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705129
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 345.27 | -0.14 | -0.14 |
| 367.42 | 0.21 | 0.21 |
| 327.30 | -0.34 | -0.34 |
| 327.35 | -0.71 | -0.71 |
| 359.30 | 0.25 | 0.25 |
| 344.29 | 0.47 | 0.47 |
| 352.36 | 0.24 | 0.24 |
| 353.35 | -0.37 | -0.37 |
| 339.32 | -0.06 | -0.06 |