Basic Information
ID: ALA3705165
Type: Binding
Description: Enzyme Assay: The inhibition of ALK tyrosine kinase activity may be demonstrated using known methods, for example using the recombinant kinase domain of the ALK in analogy to the VEGF-R kinase assay described in J. Wood et al. Cancer Res. 60, 2178-2189 (2000).
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705165
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 643.25 | 6.16 | 6.16 |
| 615.20 | 5.38 | 5.38 |
| 651.18 | 5.98 | 5.98 |
| 670.20 | 7.00 | 7.00 |
| 670.20 | 7.00 | 7.00 |
| 655.26 | 6.35 | 6.35 |
| 663.19 | 6.17 | 6.17 |
| 684.26 | 5.09 | 5.09 |
| 724.33 | 6.02 | 6.02 |
| 696.27 | 5.24 | 5.24 |
| 696.27 | 5.29 | 5.29 |
| 710.30 | 5.63 | 5.63 |
| 710.30 | 5.63 | 5.63 |
| 682.25 | 4.75 | 4.75 |
| 696.27 | 5.09 | 5.09 |
| 628.16 | 3.54 | 3.54 |
| 640.17 | 3.73 | 3.73 |
| 654.19 | 4.07 | 4.07 |
| 648.83 | 5.39 | 5.39 |
| 675.78 | 6.22 | 6.22 |
| 647.72 | 5.44 | 5.44 |
| 634.81 | 4.92 | 4.92 |
| 662.86 | 5.69 | 5.69 |
| 685.85 | 6.03 | 6.03 |
| 685.85 | 6.03 | 6.03 |
| 704.90 | 5.46 | 5.46 |
| 688.90 | 6.13 | 6.13 |
| 575.78 | 7.10 | 7.10 |
| 591.78 | 6.24 | 6.24 |
| 634.81 | 5.09 | 5.09 |
| 648.83 | 5.35 | 5.35 |
| 621.81 | 5.60 | 5.60 |
| 635.83 | 6.25 | 6.25 |
| 697.91 | 7.61 | 7.61 |
| 649.86 | 6.51 | 6.51 |
| 683.90 | 5.65 | 5.65 |
| 563.73 | 5.46 | 5.46 |
| 549.70 | 5.11 | 5.11 |
| 648.83 | 5.48 | 5.48 |
| 688.90 | 6.23 | 6.23 |
| 676.89 | 6.08 | 6.08 |
| 662.86 | 5.74 | 5.74 |
| 689.80 | 6.53 | 6.53 |
| 689.80 | 6.53 | 6.53 |
| 505.65 | 4.80 | 4.80 |
| 655.85 | 4.87 | 4.87 |
| 519.68 | 5.14 | 5.14 |
| 695.91 | 5.79 | 5.79 |
| 695.91 | 5.79 | 5.79 |
| 550.69 | 5.54 | 5.54 |
| 676.89 | 6.08 | 6.08 |
| 688.90 | 6.23 | 6.23 |
| 669.87 | 5.96 | 5.96 |
| 576.77 | 6.50 | 6.50 |
| 633.82 | 5.70 | 5.70 |
| 590.79 | 6.84 | 6.84 |
| 620.82 | 6.20 | 6.20 |
| 688.82 | 7.13 | 7.13 |
| 688.82 | 7.13 | 7.13 |
| 578.74 | 5.32 | 5.32 |
| 592.77 | 5.71 | 5.71 |